PMID- 35026678
OWN - NLM
STAT- MEDLINE
DCOM- 20220502
LR  - 20220502
IS  - 1532-8430 (Electronic)
IS  - 0022-0736 (Linking)
VI  - 71
DP  - 2022 Mar-Apr
TI  - Terminal T-wave inversion predicts reperfusion tachyarrhythmias in STEMI.
PG  - 28-31
LID - S0022-0736(21)00304-6 [pii]
LID - 10.1016/j.jelectrocard.2021.12.008 [doi]
AB  - INTRODUCTION: A reliable electrocardiographic predictor of ventricular 
      fibrillation (VF) in patients with ST elevation myocardial infarction (STEMI) is 
      lacking so far. Previous experimental/simulation study suggested a terminal 
      T-wave inversion (TTWI) in ischemia-related ECG leads corresponding to anterior 
      infarct localization as an independent predictor of reperfusion VF (rVF). This 
      T-wave characteristic has never been tested as a rVF predictor in clinical 
      settings. The aim of this study was to test if terminal T-wave inversion (TTWI) 
      at admission ECG (before reperfusion) can serve as a predictor of ventricular 
      fibrillation during reperfusion (rVF) in patients with anterior STEMI undergoing 
      primary PCI. METHODS AND RESULTS: Study population included consecutive patients 
      with anterior infarct localization admitted for primary PCI (n = 181, age 65 [57; 
      76] years, 66% male). Of those, 14 patients had rVF (rVF group, age 59 [47; 76] 
      years, 64% male) and patients without rVF comprised the No-rVF group (n = 167, 
      age 65 [57; 76] years, 66% male). Association of TTWI with rVF was analyzed using 
      logistic regression analysis adjusted for relevant clinical and 
      electrocardiographic covariates. The prevalence of TTWI in rVF group was 62% 
      comparing to 23% in the No-rVF group, p = 0.005. TTWI was associated with 
      increased risk of rVF (OR 5.51; 95% CI 1.70-17.89; p = 0.004) and remained a 
      significant predictor after adjustment for age, gender, history of MI prior to 
      index admission, VF before reperfusion, T(peak)-T(end), maximal ST elevation, and 
      QRS duration (OR 23.49; 95% CI 3.14-175.91; p = 0.002). CONCLUSIONS: The terminal 
      T-wave inversion in anterior leads before PCI independently predicted rVF in 
      patients with anterior MI thus confirming the previous experimental/simulation 
      findings.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Sedova, Ksenia A
AU  - Sedova KA
AD  - Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech 
      Technical University in Prague, Kladno, Czech Republic. Electronic address: 
      ksenia.sedova@fbmi.cvut.cz.
FAU - Demidova, Marina M
AU  - Demidova MM
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden; V.A. 
      Almazov National Medical Research Center, Saint Petersburg, Russia.
FAU - Azarov, Jan E
AU  - Azarov JE
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden; 
      Department of Cardiac Physiology, Institute of Physiology, Komi Science Center, 
      Ural Branch of Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
FAU - Hejda, Jan
AU  - Hejda J
AD  - Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech 
      Technical University in Prague, Kladno, Czech Republic.
FAU - Carlson, Jonas
AU  - Carlson J
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
FAU - Bernikova, Olesya G
AU  - Bernikova OG
AD  - Department of Cardiac Physiology, Institute of Physiology, Komi Science Center, 
      Ural Branch of Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
FAU - Arteyeva, Natalia
AU  - Arteyeva N
AD  - Department of Cardiac Physiology, Institute of Physiology, Komi Science Center, 
      Ural Branch of Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
FAU - Erlinge, David
AU  - Erlinge D
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
FAU - Platonov, Pyotr G
AU  - Platonov PG
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden; 
      Arrhythmia Clinic, Skane University Hospital, 22185 Lund, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220105
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
SB  - IM
MH  - Aged
MH  - *Anterior Wall Myocardial Infarction
MH  - Electrocardiography/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Percutaneous Coronary Intervention
MH  - Reperfusion/adverse effects
MH  - Retrospective Studies
MH  - *ST Elevation Myocardial Infarction/complications/diagnosis
MH  - Tachycardia
MH  - Ventricular Fibrillation/etiology
OTO - NOTNLM
OT  - Myocardial ischemia
OT  - ST-elevation myocardial infarction
OT  - T-wave
OT  - Ventricular fibrillation
EDAT- 2022/01/14 06:00
MHDA- 2022/05/03 06:00
CRDT- 2022/01/13 20:32
PHST- 2021/09/29 00:00 [received]
PHST- 2021/11/15 00:00 [revised]
PHST- 2021/12/23 00:00 [accepted]
PHST- 2022/01/14 06:00 [pubmed]
PHST- 2022/05/03 06:00 [medline]
PHST- 2022/01/13 20:32 [entrez]
AID - S0022-0736(21)00304-6 [pii]
AID - 10.1016/j.jelectrocard.2021.12.008 [doi]
PST - ppublish
SO  - J Electrocardiol. 2022 Mar-Apr;71:28-31. doi: 10.1016/j.jelectrocard.2021.12.008. 
      Epub 2022 Jan 5.