PMID- 35027074
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20240405
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 21
IP  - 1
DP  - 2022 Jan 14
TI  - (Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition 
      (WHEN) to Curb Obesity and Related Disorders.
PG  - 9
LID - 10.1186/s12944-021-01609-3 [doi]
LID - 9
AB  - The discovery of the endocannabinoidome (eCBome) is evolving gradually with yet 
      to be elucidated functional lipid mediators and receptors. The diet modulates 
      these bioactive lipids and the gut microbiome, both working in an entwined 
      alliance. Mounting evidence suggests that, in different ways and with a certain 
      specialisation, lipid signalling mediators such as N-acylethanolamines (NAEs), 
      2-monoacylglycerols (2-MAGs), and N-acyl-amino acids (NAAs), along with 
      endocannabinoids (eCBs), can modulate physiological mechanisms underpinning 
      appetite, food intake, macronutrient metabolism, pain sensation, blood pressure, 
      mood, cognition, and immunity. This knowledge has been primarily utilised in 
      pharmacology and medicine to develop many drugs targeting the fine and specific 
      molecular pathways orchestrating eCB and eCBome activity. Conversely, the 
      contribution of dietary NAEs, 2-MAGs and eCBs to the biological functions of 
      these molecules has been little studied. In this review, we discuss the 
      importance of (Wh) olistic (E)ndocannabinoidome-Microbiome-Axis Modulation 
      through (N) utrition (WHEN), in the management of obesity and related disorders.
CI  - (c) 2022. The Author(s).
FAU - Sihag, Jyoti
AU  - Sihag J
AUID- ORCID: 0000-0002-3218-4292
AD  - Faculty of Medicine, University of Laval, Quebec, Canada. 
      Jyoti.Sihag.1@ulaval.ca.
AD  - Faculty of Agriculture and Food Sciences, University of Laval, Quebec, Canada. 
      Jyoti.Sihag.1@ulaval.ca.
AD  - Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in 
      Metabolic Health (CERC-MEND), University of Laval, Quebec, Canada. 
      Jyoti.Sihag.1@ulaval.ca.
AD  - University Institute of Cardiology and Pneumology, Quebec, Canada. 
      Jyoti.Sihag.1@ulaval.ca.
AD  - Institute of Nutrition and Functional Foods (INAF) and Centre Nutrition, Sante et 
      Societe (NUTRISS), University of Laval, Quebec, Canada. Jyoti.Sihag.1@ulaval.ca.
AD  - Department of Foods and Nutrition, Chaudhary Charan Singh Haryana Agricultural 
      University, Hisar, India. Jyoti.Sihag.1@ulaval.ca.
FAU - Di Marzo, Vincenzo
AU  - Di Marzo V
AUID- ORCID: 0000-0002-1490-3070
AD  - Faculty of Medicine, University of Laval, Quebec, Canada. 
      vincenzo.dimarzo.1@ulaval.ca.
AD  - Faculty of Agriculture and Food Sciences, University of Laval, Quebec, Canada. 
      vincenzo.dimarzo.1@ulaval.ca.
AD  - Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in 
      Metabolic Health (CERC-MEND), University of Laval, Quebec, Canada. 
      vincenzo.dimarzo.1@ulaval.ca.
AD  - University Institute of Cardiology and Pneumology, Quebec, Canada. 
      vincenzo.dimarzo.1@ulaval.ca.
AD  - Institute of Nutrition and Functional Foods (INAF) and Centre Nutrition, Sante et 
      Societe (NUTRISS), University of Laval, Quebec, Canada. 
      vincenzo.dimarzo.1@ulaval.ca.
AD  - Institute of Biomolecular Chemistry of the National Research Council (ICB-CNR), 
      Naples, Italy. vincenzo.dimarzo.1@ulaval.ca.
AD  - Endocannabinoid Research Group, Naples, Italy. vincenzo.dimarzo.1@ulaval.ca.
AD  - Joint International Research Unit between the Italian National Research Council 
      (CNR) and University of Laval, for Chemical and Biomolecular Research on the 
      Microbiome and its impact on Metabolic Health and Nutrition (UMI-MicroMeNu), 
      Quebec, Canada. vincenzo.dimarzo.1@ulaval.ca.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220114
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Endocannabinoids)
RN  - 0 (Receptors, Cannabinoid)
SB  - IM
MH  - Animals
MH  - Endocannabinoids/*metabolism/physiology
MH  - *Gastrointestinal Microbiome/physiology
MH  - Humans
MH  - *Nutritional Physiological Phenomena/physiology
MH  - Obesity/diet therapy/etiology/*metabolism
MH  - Receptors, Cannabinoid/metabolism
PMC - PMC8759188
OTO - NOTNLM
OT  - Endocannabinoidome
OT  - Endocannabinoids
OT  - Microbiome
OT  - Nutrition
OT  - Obesity
COIS- The authors have no conflicts of interest to declare in the development of this 
      manuscript.
EDAT- 2022/01/15 06:00
MHDA- 2022/03/19 06:00
PMCR- 2022/01/14
CRDT- 2022/01/14 05:32
PHST- 2021/10/14 00:00 [received]
PHST- 2021/12/05 00:00 [accepted]
PHST- 2022/01/14 05:32 [entrez]
PHST- 2022/01/15 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2022/01/14 00:00 [pmc-release]
AID - 10.1186/s12944-021-01609-3 [pii]
AID - 1609 [pii]
AID - 10.1186/s12944-021-01609-3 [doi]
PST - epublish
SO  - Lipids Health Dis. 2022 Jan 14;21(1):9. doi: 10.1186/s12944-021-01609-3.