PMID- 35028065
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 2213-8862 (Electronic)
IS  - 1991-7902 (Print)
IS  - 1991-7902 (Linking)
VI  - 17
IP  - 1
DP  - 2022 Jan
TI  - Tumor necrosis factor-alpha enhances the expression of vascular endothelial growth 
      factor in a mouse orthodontic tooth movement model.
PG  - 415-420
LID - 10.1016/j.jds.2021.08.011 [doi]
AB  - BACKGROUND/PURPOSE: Tooth movement that is achieved using orthodontic mechanical 
      principles relies on bone resorption which takes place on the compression side 
      via osteoclasts. Tumor necrosis factor-alpha (TNF-alpha) has been known to affect 
      osteoclast formation in orthodontic tooth movement (OTM). Vascular endothelial 
      growth factor (VEGF), which is one of the mediators of angiogenesis, also plays 
      an important role in OTM by inducing vascular permeability and chemotaxis of 
      osteoclast precursors. Therefore, the purpose of this research was to evaluate 
      the effect of TNF-alpha on VEGF expression during OTM. MATERIALS AND METHODS: In 
      order to demonstrate the effect of TNF-alpha on VEGF expression during OTM, a nickel 
      titanium closed coil spring was fixed to the upper left first molar and the 
      alveolar bone beneath the upper incisors of both wild type (WT) and TNF receptors 
      (TNFRs) deficient mice resulting in a mesial movement of the molar for 12 days. 
      The maxilla was removed for histological analysis and real-time RCR analysis of 
      VEGF expression. RESULTS: Immunohistochemical analysis revealed that there were 
      fewer VEGF-positive cells in the periodontal membrane on the mesial side of the 
      distobuccal root in TNFRs-deficient mice than that in WT mice during the OTM for 
      12 days. Furthermore, expression of VEGF mRNA is lower level in TNFRs-deficient 
      mice than that in WT mice. CONCLUSION: Our results indicate that TNF-alpha plays an 
      important role in VEGF expression during tooth movement.
CI  - (c) 2021 Association for Dental Sciences of the Republic of China. Publishing 
      services by Elsevier B.V.
FAU - Noguchi, Takahiro
AU  - Noguchi T
AD  - Division of Orthodontics and Dentofacial Orthopedics, Department of Translational 
      Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan.
FAU - Kitaura, Hideki
AU  - Kitaura H
AD  - Division of Orthodontics and Dentofacial Orthopedics, Department of Translational 
      Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan.
FAU - Marahleh, Aseel
AU  - Marahleh A
AD  - Division of Orthodontics and Dentofacial Orthopedics, Department of Translational 
      Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan.
FAU - Ohori, Fumitoshi
AU  - Ohori F
AD  - Division of Orthodontics and Dentofacial Orthopedics, Department of Translational 
      Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan.
FAU - Nara, Yasuhiko
AU  - Nara Y
AD  - Division of Orthodontics and Dentofacial Orthopedics, Department of Translational 
      Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan.
FAU - Pramusita, Adya
AU  - Pramusita A
AD  - Division of Orthodontics and Dentofacial Orthopedics, Department of Translational 
      Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan.
FAU - Kinjo, Ria
AU  - Kinjo R
AD  - Division of Orthodontics and Dentofacial Orthopedics, Department of Translational 
      Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan.
FAU - Ma, Jinghan
AU  - Ma J
AD  - Division of Orthodontics and Dentofacial Orthopedics, Department of Translational 
      Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan.
FAU - Kanou, Kayoko
AU  - Kanou K
AD  - Division of Orthodontics and Dentofacial Orthopedics, Department of Translational 
      Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan.
FAU - Mizoguchi, Itaru
AU  - Mizoguchi I
AD  - Division of Orthodontics and Dentofacial Orthopedics, Department of Translational 
      Medicine, Tohoku University Graduate School of Dentistry, Sendai, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210901
PL  - Netherlands
TA  - J Dent Sci
JT  - Journal of dental sciences
JID - 101293181
PMC - PMC8739756
OTO - NOTNLM
OT  - Bone resorption
OT  - Mouse
OT  - Orthodontics
OT  - Osteoclast
OT  - Tooth movement
OT  - VEGF
COIS- The authors declare that this research was conducted in the absence of any 
      relationships that could be construed as a potential conflict of interest.
EDAT- 2022/01/15 06:00
MHDA- 2022/01/15 06:01
PMCR- 2021/09/01
CRDT- 2022/01/14 06:02
PHST- 2021/07/14 00:00 [received]
PHST- 2021/08/19 00:00 [revised]
PHST- 2022/01/14 06:02 [entrez]
PHST- 2022/01/15 06:00 [pubmed]
PHST- 2022/01/15 06:01 [medline]
PHST- 2021/09/01 00:00 [pmc-release]
AID - S1991-7902(21)00202-6 [pii]
AID - 10.1016/j.jds.2021.08.011 [doi]
PST - ppublish
SO  - J Dent Sci. 2022 Jan;17(1):415-420. doi: 10.1016/j.jds.2021.08.011. Epub 2021 Sep 
      1.