PMID- 35028210
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220115
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 12
DP  - 2021 Dec
TI  - Bone Marrow Aspirate in Spine Surgery: Case Series and Review of the Literature.
PG  - e20309
LID - 10.7759/cureus.20309 [doi]
LID - e20309
AB  - Background With the modernization of biotechnology, there has been a concerted 
      effort to create novel biomaterials to promote arthrodesis for spine surgery. The 
      novel use of the stem cells from bone marrow aspirate (BMA) to augment spine 
      surgery is a burgeoning field because these cells are considered to be both 
      osteoinductive and osteogenic. We sought to review the evidence behind the use of 
      BMAs in spinal fusions and report the results of our own case series. Methods 
      PubMed and EMBASE databases were searched for studies that investigated the use 
      of stem cells for spine surgery. For our own case series, the medical records of 
      150 consecutive patients who underwent a lumbar spinal fusion with BMA were 
      retrospectively reviewed for adverse events (AEs) for up to two years after 
      surgery. Results In our case series, there were no AEs identified in 49% of our 
      patients. Of the identified AEs, 61% were unrelated to the use of BMA (e.g., UTI 
      and heart failure), with the remaining 39% likely unrelated to its use (e.g., 
      back pain and anemia). There was a 92.8% arthrodesis rate with the use of BMA. 
      Conclusions We reviewed the rationale, basic science, and clinical science for 
      BMA usage in spine surgery and concluded that BMA is safe for use in spine 
      surgery and is associated with a high rate of arthrodesis.
CI  - Copyright (c) 2021, Noh et al.
FAU - Noh, Thomas
AU  - Noh T
AD  - Division of Neurological Surgery, University of Hawaii John A. Burns School of 
      Medicine, Honolulu, USA.
FAU - Zakaria, Hesham
AU  - Zakaria H
AD  - Department of Neurological Surgery, Henry Ford Health System, Detroit, USA.
FAU - Massie, Lara
AU  - Massie L
AD  - Department of Neurological Surgery, Henry Ford Health System, Detroit, USA.
FAU - Ogasawara, Christian T
AU  - Ogasawara CT
AD  - Division of Neurological Surgery, University of Hawaii John A. Burns School of 
      Medicine, Honolulu, USA.
FAU - Lee, Gunnar A
AU  - Lee GA
AD  - Division of Neurological Surgery, University of Hawaii John A. Burns School of 
      Medicine, Honolulu, USA.
FAU - Chedid, Mokbel
AU  - Chedid M
AD  - Department of Neurological Surgery, Henry Ford Health System, Detroit, USA.
LA  - eng
PT  - Journal Article
DEP - 20211209
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8748018
OTO - NOTNLM
OT  - arthrodesis
OT  - bone marrow aspirate
OT  - case series
OT  - literature review
OT  - mesenchymal stem cells
OT  - spine surgery
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/01/15 06:00
MHDA- 2022/01/15 06:01
PMCR- 2021/12/09
CRDT- 2022/01/14 06:04
PHST- 2021/12/08 00:00 [accepted]
PHST- 2022/01/14 06:04 [entrez]
PHST- 2022/01/15 06:00 [pubmed]
PHST- 2022/01/15 06:01 [medline]
PHST- 2021/12/09 00:00 [pmc-release]
AID - 10.7759/cureus.20309 [doi]
PST - epublish
SO  - Cureus. 2021 Dec 9;13(12):e20309. doi: 10.7759/cureus.20309. eCollection 2021 
      Dec.