PMID- 35030653
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220118
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 2
IP  - 5
DP  - 2019 May 20
TI  - Tunable Hollow Bimetallic MnFe Prussian Blue Analogue as the Targeted 
      pH-Responsive Delivery System for Anticancer Drugs.
PG  - 2143-2154
LID - 10.1021/acsabm.9b00129 [doi]
AB  - Owning to the improved ability of selectivity and penetration toward cancer 
      cells, drug delivery systems (DDSs) play essential roles in chemotherapy for 
      solid tumors. Herein, a series of bimetallic MnFe Prussian blue analogues (PBAs) 
      with a tunable nanostructure was prepared by using sodium citrate (SC) as a 
      structure regulator (represented by MnFe-PBA-SC). An advanced targeted drug 
      delivery system was obtained by adding folic acid (FA) to the preparation system 
      of MnFe-PBA-SC nanospheres (denoted as MnFe-PBA-SC-FA). The shape of pure MnFe 
      PBA was changed from a typical nanocube to a hollow nanosphere when adding SC, 
      leading to the formation of the core-shell nanospheres of the MnFe-PBA-SC-FA 
      composite. The hollow nanostructures and intrinsic cavities in PBA can carry 
      large amounts of doxorubicin (DOX), showing a high loading efficiency of 
      MnFe-PBA-SC(1.0)-FA (91.8%), which was higher than that in MnFe-PBA-SC(0.5) 
      (63.2%). Additionally, the series of MnFe-PBAs showed pH-responsive drug release 
      behaviors. A cell viability assay illustrated no remarkable cytotoxicity of 
      MnFe-PBA-SC-FA against human breast cancer cells, Michigan Cancer Foundation-7 
      (MCF-7) cells, for 24 h. Confocal laser scanning showed that the 
      MnFe-PBA-SC(1.0)-FA/DOX system significantly entered FA receptor-expressing MCF-7 
      cells in vitro and in vivo, while an increased DOX release was observed in the 
      cytoplasm of the MCF-7 cells. In consequence, this novel anticancer delivery 
      system based on bimetallic PBAs can be potentially applied to drug delivery.
FAU - Jia, Qiaojuan
AU  - Jia Q
AD  - School of Materials and Chemical Engineering, Zhengzhou University of Light 
      Industry, No. 136, Science Avenue, Zhengzhou 450001, People's Republic of China.
FAU - Su, Fangfang
AU  - Su F
AD  - School of Materials and Chemical Engineering, Zhengzhou University of Light 
      Industry, No. 136, Science Avenue, Zhengzhou 450001, People's Republic of China.
FAU - Li, Zhenzhen
AU  - Li Z
AD  - School of Materials and Chemical Engineering, Zhengzhou University of Light 
      Industry, No. 136, Science Avenue, Zhengzhou 450001, People's Republic of China.
FAU - Huang, Xiaoyu
AU  - Huang X
AD  - Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 
      No. 1, Jianshe East Road, Zhengzhou 450052, People's Republic of China.
FAU - He, Linghao
AU  - He L
AD  - School of Materials and Chemical Engineering, Zhengzhou University of Light 
      Industry, No. 136, Science Avenue, Zhengzhou 450001, People's Republic of China.
FAU - Wang, Minghua
AU  - Wang M
AD  - School of Materials and Chemical Engineering, Zhengzhou University of Light 
      Industry, No. 136, Science Avenue, Zhengzhou 450001, People's Republic of China.
FAU - Zhang, Zhihong
AU  - Zhang Z
AUID- ORCID: 0000-0002-5888-4107
AD  - School of Materials and Chemical Engineering, Zhengzhou University of Light 
      Industry, No. 136, Science Avenue, Zhengzhou 450001, People's Republic of China.
FAU - Fang, Shaoming
AU  - Fang S
AD  - School of Materials and Chemical Engineering, Zhengzhou University of Light 
      Industry, No. 136, Science Avenue, Zhengzhou 450001, People's Republic of China.
FAU - Zhou, Nan
AU  - Zhou N
AD  - Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 
      No. 1, Jianshe East Road, Zhengzhou 450052, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20190508
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
SB  - IM
OTO - NOTNLM
OT  - MnFe Prussian blue analogues
OT  - anticancer drug
OT  - hollow nanocarrier
OT  - targeted drug delivery
EDAT- 2019/05/20 00:00
MHDA- 2019/05/20 00:01
CRDT- 2022/01/15 01:00
PHST- 2022/01/15 01:00 [entrez]
PHST- 2019/05/20 00:00 [pubmed]
PHST- 2019/05/20 00:01 [medline]
AID - 10.1021/acsabm.9b00129 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2019 May 20;2(5):2143-2154. doi: 10.1021/acsabm.9b00129. Epub 
      2019 May 8.