PMID- 35030701
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220118
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 2
IP  - 6
DP  - 2019 Jun 17
TI  - Bone Marrow Mesenchymal Stem Cells Encapsulated in a Hydrogel System via 
      Bioorthogonal Chemistry for Liver Regeneration.
PG  - 2444-2452
LID - 10.1021/acsabm.9b00156 [doi]
AB  - Liver tissue engineering is going to be an effective treatment for end-stage 
      liver disease. In this work, we distributed bone marrow mesenchymal stem cells 
      (BMSCs) into a fast-forming hydrogel system to develop a liver-mimicking 
      construct for liver regeneration. The advantage of this hydrogel system was that 
      this BMSC-encapsulating hydrogel could be formed via a bioorthogonal reaction 
      between 2-cyanobenzothiazole and cysteine within several seconds. Thereafter, we 
      explored the morphology, biocompatibility, and expressions of hepatic 
      differentiation markers of this hydrogel system. These results illustrated that 
      this system could provide a suitable niche for BMSC proliferation and 
      differentiation, which could aid in future biomedical research of liver 
      regeneration.
FAU - Zhang, Yajie
AU  - Zhang Y
AUID- ORCID: 0000-0002-9916-080X
AD  - School of Nano Technology and Nano Bionics, University of Science and Technology 
      of China, Hefei 230026, China.
AD  - CAS Key Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou 
      Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 
      215123, China.
FAU - Zan, Yue
AU  - Zan Y
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
FAU - Chen, Hong
AU  - Chen H
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
FAU - Wang, Zhili
AU  - Wang Z
AD  - School of Nano Technology and Nano Bionics, University of Science and Technology 
      of China, Hefei 230026, China.
FAU - Ni, Tianyu
AU  - Ni T
AD  - CAS Key Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou 
      Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 
      215123, China.
FAU - Liu, Min
AU  - Liu M
AUID- ORCID: 0000-0003-4779-8489
AD  - Institute for Interdisciplinary Research, Jianghan University, Wuhan 430056, 
      China.
FAU - Pei, Renjun
AU  - Pei R
AUID- ORCID: 0000-0002-9353-3935
AD  - School of Nano Technology and Nano Bionics, University of Science and Technology 
      of China, Hefei 230026, China.
AD  - CAS Key Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou 
      Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 
      215123, China.
LA  - eng
PT  - Journal Article
DEP - 20190515
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
SB  - IM
OTO - NOTNLM
OT  - BMSC-encapsulating
OT  - bioorthogonal reaction
OT  - fast-forming hydrogel
OT  - liver regeneration
OT  - tissue engineering
EDAT- 2019/06/17 00:00
MHDA- 2019/06/17 00:01
CRDT- 2022/01/15 01:00
PHST- 2022/01/15 01:00 [entrez]
PHST- 2019/06/17 00:00 [pubmed]
PHST- 2019/06/17 00:01 [medline]
AID - 10.1021/acsabm.9b00156 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2019 Jun 17;2(6):2444-2452. doi: 10.1021/acsabm.9b00156. Epub 
      2019 May 15.