PMID- 35032569
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 161
DP  - 2022 Mar
TI  - Coffee constituents with antiadipogenic and antidiabetic potentials: A narrative 
      review.
PG  - 112821
LID - S0278-6915(22)00018-7 [pii]
LID - 10.1016/j.fct.2022.112821 [doi]
AB  - Coffee consumption has been associated with the reduction of several chronic 
      diseases, including type 2 diabetes mellitus (T2DM) and obesity. The aim of this 
      review was to summarize the research conducted in the last five years (or older, 
      when appropriate) on the relationship between the consumption of coffee bioactive 
      compounds, obesity, and T2DM. A bibliographic search was performed using the Web 
      of Sciences, Scopus, and Google Scholar. Keywords used were "caffeine," "coffee," 
      "coffee consumption," "coffee extraction," "coffee bioactive components," 
      "chlorogenic acid," "obesity," "antidiabetic," and "antiadipogenic." 
      Epidemiological, clinical, animal, and cell culture studies were reviewed. 
      Caffeine, chlorogenic acid, and diterpenes have been identified as potential 
      bioactive compounds in coffee that exhibit antiadipogenic and antidiabetic 
      effects. The concentration of these compounds in coffee depends on the coffee 
      preparation method. The relationship between coffee consumption and obesity risk 
      is inconsistent, as not all results report a positive association. The addition 
      of sugar and cream may be responsible for these mixed results. The consumption of 
      coffee and its constituents is consistently associated with a lower T2DM risk. 
      Caffeine, chlorogenic acids, and diterpenes have antidiabetic properties and are 
      associated with these effects. The available data do not allow us to draw a 
      conclusion on the effect of coffee or its constituents on adipogenesis. 
      Therefore, more tightly controlled human intervention studies are required for a 
      deeper understanding about this relationship.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Kusumah, Jennifer
AU  - Kusumah J
AD  - Department of Food Science and Human Nutrition, University of Illinois, 
      Urbana-Champaign, 1201 West Gregory Drive, Urbana, IL, 61801, United States.
FAU - Gonzalez de Mejia, Elvira
AU  - Gonzalez de Mejia E
AD  - Department of Food Science and Human Nutrition, University of Illinois, 
      Urbana-Champaign, 1201 West Gregory Drive, Urbana, IL, 61801, United States. 
      Electronic address: edemejia@illinois.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220113
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Coffee)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Adipogenesis/*drug effects
MH  - Animals
MH  - Coffee/*chemistry
MH  - Diabetes Mellitus, Type 2/*prevention & control
MH  - Humans
MH  - Hypoglycemic Agents/*pharmacology
OTO - NOTNLM
OT  - Adipogenesis
OT  - Coffee
OT  - Diabetes
OT  - Insulin resistance
OT  - Phenolic compounds
OT  - T2DM
EDAT- 2022/01/16 06:00
MHDA- 2022/03/17 06:00
CRDT- 2022/01/15 20:11
PHST- 2020/10/25 00:00 [received]
PHST- 2022/01/01 00:00 [revised]
PHST- 2022/01/10 00:00 [accepted]
PHST- 2022/01/16 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2022/01/15 20:11 [entrez]
AID - S0278-6915(22)00018-7 [pii]
AID - 10.1016/j.fct.2022.112821 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2022 Mar;161:112821. doi: 10.1016/j.fct.2022.112821. Epub 2022 
      Jan 13.