PMID- 35034189
OWN - NLM
STAT- MEDLINE
DCOM- 20220509
LR  - 20220509
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 279
IP  - 6
DP  - 2022 Jun
TI  - Marital status and survival in laryngeal squamous cell carcinoma patients: a 
      multinomial propensity scores matched study.
PG  - 3005-3011
LID - 10.1007/s00405-022-07252-7 [doi]
AB  - OBJECTIVE: To explore the correlation between the marital status and prognosis of 
      patients with laryngeal squamous cell carcinoma (LSCC). STUDY DESIGN: MPSM was 
      adopted to minimize the maximum standardized average difference of the covariates 
      among the four groups with different marital status. SETTING: Multinomial 
      propensity scores matching (MPSM) based on data from the surveillance, 
      epidemiology, and end results (SEER) database. METHODS: The Kaplan-Meier method 
      and log-rank test were used to compare the survival outcomes of these groups with 
      different marital status. RESULTS: Totally, 16,981 LSCC patients (median [IQR] 
      age 62 [55-69] years; 829 [76.41%] males) from 2004 to 2016 were included in this 
      study. Among them, 9112 (53.66%) were married, 2708 (15.95%) divorced or 
      separated, 1709 (10.06%) widowed, and 3452 (20.33%) single. After MPSM, the 
      weights make the characteristics of four groups with different marital status 
      sufficient balance. The Kaplan-Meier method and log-rank test showed widowed 
      patients may lead to the highest mortality rate while married patients have a 
      higher survival rate than the other three groups. Single and divorced or 
      separated patients had no significant difference in the survival rate. In 
      addition, multivariate analysis by controlling for confounding factors showed 
      that in male, well-differentiated, and early stage patients, compared with 
      married, unmarried was an independent risk factor for CSS (P < 0.05). CONCLUSION: 
      Marital status showed a significant association with the survival status of LSCC 
      patients. Importantly, the outcome of married patients was better, while widowed 
      patients tended to have worse prognosis.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Du, Xiushuai
AU  - Du X
AD  - Department of Preventive Medicine, Fujian Provincial Key Laboratory of 
      Environment Factors and Cancer, Key Laboratory of Environment and Health, School 
      of Public Health, Fujian Medical University, Xueyuan Road No. 1, Minhou County, 
      Fuzhou, 350108, Fujian, People's Republic of China.
FAU - Zhan, Wenqiang
AU  - Zhan W
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200025, People's Republic of China.
FAU - Li, Xiaoqin
AU  - Li X
AD  - Department of Preventive Medicine, Fujian Provincial Key Laboratory of 
      Environment Factors and Cancer, Key Laboratory of Environment and Health, School 
      of Public Health, Fujian Medical University, Xueyuan Road No. 1, Minhou County, 
      Fuzhou, 350108, Fujian, People's Republic of China.
FAU - Yin, Shuo
AU  - Yin S
AD  - Department of Preventive Medicine, Fujian Provincial Key Laboratory of 
      Environment Factors and Cancer, Key Laboratory of Environment and Health, School 
      of Public Health, Fujian Medical University, Xueyuan Road No. 1, Minhou County, 
      Fuzhou, 350108, Fujian, People's Republic of China.
FAU - Chen, Qingquan
AU  - Chen Q
AD  - Department of Preventive Medicine, Fujian Provincial Key Laboratory of 
      Environment Factors and Cancer, Key Laboratory of Environment and Health, School 
      of Public Health, Fujian Medical University, Xueyuan Road No. 1, Minhou County, 
      Fuzhou, 350108, Fujian, People's Republic of China.
FAU - Huang, Jialing
AU  - Huang J
AD  - Department of Preventive Medicine, Fujian Provincial Key Laboratory of 
      Environment Factors and Cancer, Key Laboratory of Environment and Health, School 
      of Public Health, Fujian Medical University, Xueyuan Road No. 1, Minhou County, 
      Fuzhou, 350108, Fujian, People's Republic of China.
FAU - Chen, Yao
AU  - Chen Y
AD  - Department of Preventive Medicine, Fujian Provincial Key Laboratory of 
      Environment Factors and Cancer, Key Laboratory of Environment and Health, School 
      of Public Health, Fujian Medical University, Xueyuan Road No. 1, Minhou County, 
      Fuzhou, 350108, Fujian, People's Republic of China.
FAU - Liu, Jin
AU  - Liu J
AUID- ORCID: 0000-0002-4506-1638
AD  - Department of Preventive Medicine, Fujian Provincial Key Laboratory of 
      Environment Factors and Cancer, Key Laboratory of Environment and Health, School 
      of Public Health, Fujian Medical University, Xueyuan Road No. 1, Minhou County, 
      Fuzhou, 350108, Fujian, People's Republic of China. liujin@fjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220116
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Female
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Marital Status
MH  - Middle Aged
MH  - Prognosis
MH  - Propensity Score
MH  - SEER Program
MH  - Squamous Cell Carcinoma of Head and Neck
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - Marriage
OT  - Multinomial propensity scores matching
OT  - SEER
EDAT- 2022/01/17 06:00
MHDA- 2022/05/10 06:00
CRDT- 2022/01/16 21:14
PHST- 2021/10/20 00:00 [received]
PHST- 2022/01/01 00:00 [accepted]
PHST- 2022/01/17 06:00 [pubmed]
PHST- 2022/05/10 06:00 [medline]
PHST- 2022/01/16 21:14 [entrez]
AID - 10.1007/s00405-022-07252-7 [pii]
AID - 10.1007/s00405-022-07252-7 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2022 Jun;279(6):3005-3011. doi: 
      10.1007/s00405-022-07252-7. Epub 2022 Jan 16.