PMID- 35034888
OWN - NLM
STAT- MEDLINE
DCOM- 20220315
LR  - 20220315
IS  - 1011-601X (Print)
IS  - 1011-601X (Linking)
VI  - 34
IP  - 6
DP  - 2021 Nov
TI  - SHORT COMMUNICATION-Inappropriate use of proton pump inhibitor for stress ulcer 
      prophylaxis in a tertiary care hospital in Karachi, Pakistan.
PG  - 2253-2255
AB  - The use of proton pump inhibitors (PPI) has been expanded inappropriately. PPI 
      are among the most selling drugs in the world. There is growing evidence that PPI 
      are associated with significant adverse effects along with undue financial 
      burden. Inappropriate prescription of PPI is common in inpatients. The objective 
      is to determine the frequency of inappropriate use of proton pump inhibitors for 
      stress ulcer prophylaxis. This prospective observational study was conducted in 
      the Department of Medicine of The Aga Khan University Hospital Karachi. 151 adult 
      patients admitted in the hospital were included. All those patients who received 
      PPI due to a condition mentioned by American Gastroenterology Association (AGA) 
      as an indication for PPI, were labeled as PPI appropriately indicated. While 
      those patients who received PPI without a condition mentioned by AGA as an 
      indication for PPI, were labeled as PPI inappropriately indicated. Mean age was 
      57.2+/-18.2 years. Route of administration was oral in 110 (72.8%) and IV in 41 
      (27.2%) patients. Out of 151 patients, 100 (66.2%) patients were receiving PPI 
      without any specific indication while 51 (33.8%) patients were receiving PPI with 
      appropriate indications. Our study showed that inappropriate use of PPI is quite 
      common among admitted patients.
FAU - Samar, Rohama
AU  - Samar R
AD  - Department of Medicine, Faculty Office Building, The Aga Khan University 
      Hospital, Karachi, Pakistan.
FAU - Ali, Syed Ahsan
AU  - Ali SA
AD  - Department of Medicine, Faculty Office Building, The Aga Khan University 
      Hospital, Karachi, Pakistan.
FAU - Samar, Victoria
AU  - Samar V
AD  - Department of Medicine, Faculty Office Building, The Aga Khan University 
      Hospital, Karachi, Pakistan.
FAU - Mushtaq, Muhammad Zain
AU  - Mushtaq MZ
AD  - Department of Medicine, Faculty Office Building, The Aga Khan University 
      Hospital, Karachi, Pakistan.
FAU - Humayun, Arsalan
AU  - Humayun A
AD  - Department of Medicine, Faculty Office Building, The Aga Khan University 
      Hospital, Karachi, Pakistan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Pakistan
TA  - Pak J Pharm Sci
JT  - Pakistan journal of pharmaceutical sciences
JID - 9426356
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Ulcer Agents/adverse effects/*therapeutic use
MH  - Female
MH  - Humans
MH  - Inappropriate Prescribing/*trends
MH  - Male
MH  - Middle Aged
MH  - Pakistan
MH  - Practice Patterns, Physicians'/*trends
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/adverse effects/*therapeutic use
MH  - *Tertiary Care Centers
MH  - Ulcer/diagnosis/etiology/*prevention & control
EDAT- 2022/01/18 06:00
MHDA- 2022/03/16 06:00
CRDT- 2022/01/17 05:41
PHST- 2022/01/17 05:41 [entrez]
PHST- 2022/01/18 06:00 [pubmed]
PHST- 2022/03/16 06:00 [medline]
PST - ppublish
SO  - Pak J Pharm Sci. 2021 Nov;34(6):2253-2255.