PMID- 35035688
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240405
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 13
IP  - 12
DP  - 2021
TI  - Effects of ticagrelor on proliferation, apoptosis, and inflammatory factors of 
      human aortic vascular smooth muscle cells through lncRNA KCNQ1OT1.
PG  - 13462-13470
AB  - OBJECTIVE: This study was designed to determine the effects of ticagrelor on the 
      proliferation and apoptosis of and inflammatory factors in human aortic vascular 
      smooth muscle cells (HAVSMCs). METHODS: A total of 20 patients who were first 
      diagnosed with coronary heart disease (CHD) from August 2020 to March 2021 and 20 
      healthy adults were enrolled into the study. Oxidized low-density lipoprotein 
      (ox-LDL) and different concentrations of ticagrelor were applied in the treatment 
      of HAVSMCs, and then the cell proliferation and apoptosis and the expression of 
      apoptosis-related proteins, inflammatory factors, and IkappaBalpha in them were 
      determined. RESULTS: Compared with the ox-LDL group, the OD value was 
      significantly increased after ticagrelor treatment, and the apoptosis rate was 
      significantly reduced (P<0.05); compared with the ox-LDL group, the B lymphoma-2 
      (Bcl-2) protein, IkappaB, KCNQ1OT1 expression in the ticagrelor group increased 
      significantly, Bcl-2-associated X protein (Bax), monocyte chemoattractant 
      protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) expression decreased 
      significantly (P<0.05); The expression of serum KCNQ1OT1 in patients with 
      coronary heart disease was significantly higher than that in healthy individuals 
      (P<0.05). CONCLUSION: Ticagrelor may regulate the expression of lncRNA KCNQ1OT1 
      and up-regulate the expression of IkappaBalpha to promote proliferation and 
      anti-apoptosis, so as to prevent ox-LDL from oxidative damage to HAVSMCs.
CI  - AJTR Copyright (c) 2021.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Cardiology, Henan Provincial Chest Hospital Henan, China.
FAU - Jiao, Jichao
AU  - Jiao J
AD  - Department of Neurosurgery, The 7th People's Hospital of Zhengzhou Zhengzhou, 
      Henan, China.
FAU - Wang, Daohai
AU  - Wang D
AD  - Department of Gsatroenterology, Henan Tumor Hospital Zhengzhou, Henan, China.
FAU - Song, Jingchao
AU  - Song J
AD  - Department of Cardiac Surgery, Henan Provincial Chest Hospital Henan, China.
FAU - Huang, Kejun
AU  - Huang K
AD  - Department of Cardiology, Henan Provincial Chest Hospital Henan, China.
LA  - eng
PT  - Journal Article
DEP - 20211215
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC8748171
OTO - NOTNLM
OT  - HAVSMCs
OT  - IkappaBalpha
OT  - Ticagrelor
OT  - apoptosis
OT  - inflammation
OT  - lncRNA KCNQ1OT1
OT  - proliferation
COIS- None.
EDAT- 2022/01/18 06:00
MHDA- 2022/01/18 06:01
PMCR- 2021/12/15
CRDT- 2022/01/17 05:57
PHST- 2021/04/16 00:00 [received]
PHST- 2021/08/24 00:00 [accepted]
PHST- 2022/01/17 05:57 [entrez]
PHST- 2022/01/18 06:00 [pubmed]
PHST- 2022/01/18 06:01 [medline]
PHST- 2021/12/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2021 Dec 15;13(12):13462-13470. eCollection 2021.