PMID- 35035719
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220118
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 13
IP  - 12
DP  - 2021
TI  - Butylphthalide soft capsules combined with modified tonic exercise therapy on 
      neurological function and ability of daily living of patients with stroke 
      hemiplegia.
PG  - 13803-13810
AB  - OBJECTIVE: To explore the effect of butylphthalide soft capsules combined with 
      modified tonic exercise therapy on neurologic function and the abilities of daily 
      living in patients with stroke hemiplegia. METHODS: In this retrospective trial, 
      a total of 90 patients with stroke hemiplegia admitted to our hospital from 
      January 2019 to January 2020 were enrolled and divided into a control group and 
      an experimental group according to different treatment methods. The two groups 
      were both treated with butylphthalide soft capsules, and the experimental group 
      was additionally treated by modified tonic exercise therapy. The clinical 
      efficacy, endothelial injury indicators, molecular indicators of oxidative 
      stress, and adverse reactions of the two groups were compared. Generic Quality of 
      Life Inventory-74 (GQOLI-74) was used to assess the quality of life of patients 
      after treatment. The Fugl-Meyer Upper Extremity Assessment (FMA) was used to 
      evaluate their limb function before and after treatment, the National Institute 
      of Health Stroke Scale (NIHSS) was used to evaluate their brain nerve function 
      before and after the treatment, and the activities of daily living (ADL) were 
      employed to assess their activities of daily living before and after treatment. 
      RESULTS: After treatment, the experimental group outperformed the control group 
      in terms of total clinical efficacy (P<0.05). The experimental group had 
      significantly lower endothelial injury indicators and higher molecular indicators 
      of oxidative stress than the control group (all P<0.001). The incidence of 
      adverse reactions in the experimental group was lower than that in the control 
      group (P<0.05). Higher GQOLI-74, FMA, and ADL scores and a significantly lower 
      NIHSS score were obtained in the experimental group than the control group after 
      treatment (P<0.001). CONCLUSION: For patients with stroke hemiplegia, 
      butylphthalide soft capsule combined with modified tonic exercise therapy 
      effectively improves their neurologic function, abilities of daily living, and 
      quality of life.
CI  - AJTR Copyright (c) 2021.
FAU - Lv, You
AU  - Lv Y
AD  - Department of Internal Neurology, Second Affiliated Hospital of Xuzhou Medical 
      University Jiangsu, China.
FAU - Zhang, Qingxiu
AU  - Zhang Q
AD  - Department of Internal Neurology, Second Affiliated Hospital of Xuzhou Medical 
      University Jiangsu, China.
FAU - Rong, Liangqun
AU  - Rong L
AD  - Department of Internal Neurology, Second Affiliated Hospital of Xuzhou Medical 
      University Jiangsu, China.
FAU - Wei, Xiu'e
AU  - Wei X
AD  - Department of Internal Neurology, Second Affiliated Hospital of Xuzhou Medical 
      University Jiangsu, China.
FAU - Liu, Haiyan
AU  - Liu H
AD  - Department of Internal Neurology, Second Affiliated Hospital of Xuzhou Medical 
      University Jiangsu, China.
FAU - Li, Zhining
AU  - Li Z
AD  - Department of Internal Neurology, Second Affiliated Hospital of Xuzhou Medical 
      University Jiangsu, China.
LA  - eng
PT  - Journal Article
DEP - 20211215
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC8748129
OTO - NOTNLM
OT  - Butylphthalide
OT  - hemiplegia
OT  - modified tonic exercise therapy
OT  - stroke
COIS- None.
EDAT- 2022/01/18 06:00
MHDA- 2022/01/18 06:01
PMCR- 2021/12/15
CRDT- 2022/01/17 05:57
PHST- 2021/08/26 00:00 [received]
PHST- 2021/10/21 00:00 [accepted]
PHST- 2022/01/17 05:57 [entrez]
PHST- 2022/01/18 06:00 [pubmed]
PHST- 2022/01/18 06:01 [medline]
PHST- 2021/12/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2021 Dec 15;13(12):13803-13810. eCollection 2021.