PMID- 35037133
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20221207
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 32
IP  - 4
DP  - 2022 Apr
TI  - Multiple Beneficial Effects of Laparoscopic Sleeve Gastrectomy for Patients with 
      Obesity, Type 2 Diabetes Mellitus, and Restrictive Ventilatory Dysfunction.
PG  - 1016-1023
LID - 10.1007/s11695-022-05898-0 [doi]
AB  - BACKGROUND: Some studies have suggested that bariatric surgery improves pulmonary 
      function in patients with obesity, but whether it alleviates pulmonary 
      ventilation disorders in patients with obesity, type 2 diabetes mellitus (T2DM), 
      and restrictive ventilatory dysfunction(RVD) is unclear. To evaluate the effect 
      of laparoscopic sleeve gastrectomy (LSG) in improving pulmonary ventilation 
      function in patients with obesity, T2DM, and RVD. METHODS: We studied patients 
      with T2DM and RVD (forced vital capacity (FVC) predicted < 80%, forced expiratory 
      volume in one second/forced vital capacity (FEV1/FVC) > 70%) who underwent LSG 
      from March 2018 to January 2020. Baseline data was recorded and follow-up visits 
      were made at 3, 6, 9, and 12 months after surgery to evaluate glucose, hemoglobin 
      A1c (HbA1c), body mass index (BMI), and pulmonary ventilation function. We used 
      multivariate analyses to assess the remission of RVD (reversion of FVC to >/=80% of 
      the predicted value). RESULTS: We enrolled 33 patients (mean age 46.9+/-5.2 years, 
      21 males). Two patients were lost to follow-up and another patient died. Thirty 
      patients completed follow-up; 24 had remission of RVD (24/33, 72.7%). 
      Multivariate Cox regression analysis showed that lower HbA1c (HR=0.35 (0.16 ~ 
      0.76), p=0.008), reduced waist size (0.9 (0.83 ~ 0.98), p=0.017), and shorter 
      duration of diabetes (0.67(0.47~0.97), p=0.033) were associated with alleviation 
      of pulmonary ventilation function. CONCLUSIONS: LSG not only controls the body 
      weight and T2DM; it may also relieve pulmonary ventilation dysfunction 
      in patients with obesity, T2DM, and RVD. The waist size, duration of diabetes, 
      and HbA1c before LSG negatively affect recovery of pulmonary ventilation 
      dysfunction.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Lv, Xiaodong
AU  - Lv X
AD  - Department of General Surgery, and Institute of Hepato-Biliary-Pancreas and 
      Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong, 637000, People's Republic of China.
FAU - Yang, Jingge
AU  - Yang J
AD  - Department of Gastrointestinal Surgery, First Affiliated Hospital of Jinan 
      University, Guangzhou, 510630, People's Republic of China.
FAU - Xian, Yin
AU  - Xian Y
AD  - Department of General Surgery, and Institute of Hepato-Biliary-Pancreas and 
      Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong, 637000, People's Republic of China.
FAU - Kong, Xiangxin
AU  - Kong X
AD  - Department of General Surgery, and Institute of Hepato-Biliary-Pancreas and 
      Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong, 637000, People's Republic of China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Department of General Surgery, and Institute of Hepato-Biliary-Pancreas and 
      Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong, 637000, People's Republic of China.
FAU - Liu, Chengming
AU  - Liu C
AD  - Xichong County People's Hospital, Nanchong, 637000, People's Republic of China.
FAU - He, Ming
AU  - He M
AD  - Department of General Surgery, and Institute of Hepato-Biliary-Pancreas and 
      Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong, 637000, People's Republic of China.
FAU - Cheng, Junming
AU  - Cheng J
AD  - Department of General Surgery, and Institute of Hepato-Biliary-Pancreas and 
      Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong, 637000, People's Republic of China.
FAU - Lu, Chicheng
AU  - Lu C
AD  - Department of General Surgery, and Institute of Hepato-Biliary-Pancreas and 
      Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong, 637000, People's Republic of China.
FAU - Ren, Yixing
AU  - Ren Y
AUID- ORCID: 0000-0001-5227-9064
AD  - Department of General Surgery, and Institute of Hepato-Biliary-Pancreas and 
      Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong, 637000, People's Republic of China. yixingren@nsmc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220117
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Blood Glucose
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/complications/surgery
MH  - Female
MH  - Gastrectomy
MH  - Glycated Hemoglobin
MH  - Humans
MH  - *Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/surgery
MH  - *Obesity, Morbid/surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Laparoscopic sleeve gastrectomy
OT  - Restrictive ventilatory dysfunction
OT  - Sleeve gastrectomy
OT  - Type 2 diabetes mellitus
EDAT- 2022/01/18 06:00
MHDA- 2022/04/27 06:00
CRDT- 2022/01/17 06:19
PHST- 2021/10/19 00:00 [received]
PHST- 2022/01/11 00:00 [accepted]
PHST- 2022/01/07 00:00 [revised]
PHST- 2022/01/18 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
PHST- 2022/01/17 06:19 [entrez]
AID - 10.1007/s11695-022-05898-0 [pii]
AID - 10.1007/s11695-022-05898-0 [doi]
PST - ppublish
SO  - Obes Surg. 2022 Apr;32(4):1016-1023. doi: 10.1007/s11695-022-05898-0. Epub 2022 
      Jan 17.