PMID- 35037344
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20220407
IS  - 1440-1819 (Electronic)
IS  - 1323-1316 (Linking)
VI  - 76
IP  - 4
DP  - 2022 Apr
TI  - N400 event-related brain potential and functional outcome in persons at clinical 
      high risk for psychosis: A longitudinal study.
PG  - 114-121
LID - 10.1111/pcn.13330 [doi]
AB  - BACKGROUND: The N400 event-related brain potential (ERP) semantic priming effect 
      is thought to reflect activation by meaningful stimuli of related concepts in 
      semantic memory and has been found to be deficient in schizophrenia. We tested 
      the hypothesis that, among individuals at clinical high risk (CHR) for psychosis, 
      N400 semantic priming deficits predict worse symptomatic and functional outcomes 
      after one year. METHODS: We measured N400 semantic priming at baseline in CHR 
      patients (n = 47) and healthy control participants (n = 25) who viewed prime 
      words each followed by a related or unrelated target word, at stimulus-onset 
      asynchronies (SOAs) of 300 or 750 ms. We measured patients' psychosis-like 
      symptoms with the Scale of Prodromal Symptoms (SOPS) Positive subscale, and 
      academic/occupational and social functioning with the Global Functioning 
      (GF):Role and Social scales, respectively, at baseline and one-year follow-up 
      (n = 29). RESULTS: CHR patients exhibited less N400 semantic priming than 
      controls across SOAs; planned contrasts indicated this difference was significant 
      at the 750-ms but not the 300-ms SOA. In patients, reduced N400 semantic priming 
      at the 750-ms SOA was associated with lower GF:Social scores at follow-up, and 
      greater GF:Social decrements from baseline to follow-up. Patients' N400 semantic 
      priming was not associated with SOPS Positive or GF:Role scores at follow-up, or 
      change in these from baseline to follow-up. CONCLUSIONS: In CHR patients, reduced 
      N400 semantic priming at baseline predicted worse social functioning after one 
      year, and greater decline in social functioning over this period. Thus, the N400 
      may be a useful prognostic biomarker of real-world functional outcome in CHR 
      patients.
CI  - (c) 2022 The Authors. Psychiatry and Clinical Neurosciences (c) 2022 Japanese Society 
      of Psychiatry and Neurology.
FAU - Lepock, Jennifer R
AU  - Lepock JR
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Mizrahi, Romina
AU  - Mizrahi R
AD  - Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
FAU - Gerritsen, Cory J
AU  - Gerritsen CJ
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Graduate Department of Psychological Clinical Science, University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Bagby, R Michael
AU  - Bagby RM
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Graduate Department of Psychological Clinical Science, University of Toronto, 
      Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
FAU - Maheandiran, Margaret
AU  - Maheandiran M
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Ahmed, Sarah
AU  - Ahmed S
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Korostil, Michele
AU  - Korostil M
AD  - Department of Psychiatry and Behavioural Neurosciences, McMaster University, 
      Hamilton, Ontario, Canada.
AD  - St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
FAU - Kiang, Michael
AU  - Kiang M
AUID- ORCID: 0000-0003-1113-9211
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
LA  - eng
GR  - Ontario Mental Health Foundation/
GR  - Ontario Ministry of Health and Long Term Care/
GR  - University of Toronto Department of Psychiatry/
PT  - Journal Article
DEP - 20220210
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
SB  - IM
MH  - Brain
MH  - *Electroencephalography
MH  - Evoked Potentials/physiology
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - *Psychotic Disorders
MH  - Reaction Time/physiology
MH  - Semantics
OTO - NOTNLM
OT  - event-related potentials
OT  - prodrome
OT  - schizophrenia
OT  - semantic processing
OT  - social functioning
EDAT- 2022/01/18 06:00
MHDA- 2022/04/08 06:00
CRDT- 2022/01/17 06:30
PHST- 2021/12/10 00:00 [revised]
PHST- 2021/09/15 00:00 [received]
PHST- 2021/12/27 00:00 [accepted]
PHST- 2022/01/18 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
PHST- 2022/01/17 06:30 [entrez]
AID - 10.1111/pcn.13330 [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 2022 Apr;76(4):114-121. doi: 10.1111/pcn.13330. Epub 
      2022 Feb 10.