PMID- 35038136
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20220412
IS  - 2038-3312 (Electronic)
IS  - 2038-131X (Linking)
VI  - 74
IP  - 2
DP  - 2022 Apr
TI  - A pilot randomized controlled trial on ligation of intersphincteric fistula tract 
      (LIFT) versus modified parks technique and two-stage seton in treatment of 
      complex anal fistula.
PG  - 657-666
LID - 10.1007/s13304-022-01240-6 [doi]
AB  - Complex anal fistula (CAF) is a challenging condition for surgeons. This 
      randomized trial aimed to compare ligation of the intersphincteric fistula tract 
      (LIFT), modified Parks technique, and two-stage seton in the treatment of complex 
      anal fistula in terms of the success of treatment and complications. This was a 
      pilot randomized trial conducted in the period of January 2019 to December 2019 
      on adult patients with CAF who were allocated to one of three groups: LIFT, 
      modified Parks technique, and two-stage seton. The main outcome measures were 
      healing rates, time to healing, complications, operation time, and quality of 
      life. Sixty-six patients (75.7% males) of a mean age of 45.2 years were included. 
      Mean operation time of LIFT was significantly shorter than the other two 
      procedures (p < 0.0001). There was a significant difference between the three 
      groups in terms of success rate (p = 0.04) but not in regard to complications 
      (p = 0.59). The modified Parks technique had a significantly higher success rate 
      than LIFT (95.2% vs 68.1%, p = 0.045) whereas the success rates of two-stage 
      seton and LIFT were not significantly different (86.9% vs 68.1%, p = 0.16). The 
      average time to healing after LIFT was significantly shorter than the other two 
      procedures. The quality-of-life scores were comparable among the three groups. 
      There was a significant difference in healing rates after the three procedures as 
      the modified Parks technique achieved the highest success rate followed by 
      two-stage seton and then the LIFT procedure. Time to complete healing after LIFT 
      was significantly shorter than the other two procedures. The three procedures 
      achieved similar quality of life and complication rates.
CI  - (c) 2022. Italian Society of Surgery (SIC).
FAU - Elshamy, Mohamed Tarek
AU  - Elshamy MT
AD  - Colorectal Surgery Unit, General Surgery Department, Mansoura University 
      Hospitals, Mansoura University, 60 El-Gomhouria Street, Mansoura, 35516, 
      Dakahlia, Egypt.
FAU - Emile, Sameh Hany
AU  - Emile SH
AUID- ORCID: 0000-0001-7854-5244
AD  - Colorectal Surgery Unit, General Surgery Department, Mansoura University 
      Hospitals, Mansoura University, 60 El-Gomhouria Street, Mansoura, 35516, 
      Dakahlia, Egypt. Sameh200@hotmail.com.
FAU - Abdelnaby, Mahmoud
AU  - Abdelnaby M
AD  - Colorectal Surgery Unit, General Surgery Department, Mansoura University 
      Hospitals, Mansoura University, 60 El-Gomhouria Street, Mansoura, 35516, 
      Dakahlia, Egypt.
FAU - Khafagy, Wael
AU  - Khafagy W
AD  - Colorectal Surgery Unit, General Surgery Department, Mansoura University 
      Hospitals, Mansoura University, 60 El-Gomhouria Street, Mansoura, 35516, 
      Dakahlia, Egypt.
FAU - Elbaz, Samy Abbas
AU  - Elbaz SA
AD  - Colorectal Surgery Unit, General Surgery Department, Mansoura University 
      Hospitals, Mansoura University, 60 El-Gomhouria Street, Mansoura, 35516, 
      Dakahlia, Egypt.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220117
PL  - Italy
TA  - Updates Surg
JT  - Updates in surgery
JID - 101539818
SB  - IM
MH  - Adult
MH  - Anal Canal/surgery
MH  - *Fecal Incontinence
MH  - Female
MH  - Humans
MH  - Ligation/methods
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Quality of Life
MH  - *Rectal Fistula/surgery
MH  - Recurrence
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Complex anal fistula
OT  - LIFT
OT  - Modified parks
OT  - Randomized
OT  - Seton
OT  - Two stage
EDAT- 2022/01/18 06:00
MHDA- 2022/04/13 06:00
CRDT- 2022/01/17 12:27
PHST- 2021/12/05 00:00 [received]
PHST- 2022/01/07 00:00 [accepted]
PHST- 2022/01/18 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
PHST- 2022/01/17 12:27 [entrez]
AID - 10.1007/s13304-022-01240-6 [pii]
AID - 10.1007/s13304-022-01240-6 [doi]
PST - ppublish
SO  - Updates Surg. 2022 Apr;74(2):657-666. doi: 10.1007/s13304-022-01240-6. Epub 2022 
      Jan 17.