PMID- 35038147
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220531
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1374
DP  - 2022
TI  - Cytokines in Renal Cell Carcinoma: A Step Towards Earlier Detection and Targeted 
      Therapy.
PG  - 63-72
LID - 10.1007/5584_2021_700 [doi]
AB  - Symptoms of renal cell carcinoma (RCC) have typically late onset and correlate 
      with its advanced stage. No biomarkers of RCC are currently available. The 
      present study analyzed the immuno-biochemical profile of RCC by measuring the 
      levels of cytokines engaged in RCC pathophysiology. Cytokines were examined by 
      capture sandwich immunoassays in tumor tissue and urine. Specimens of cancer and 
      nearby healthy kidney tissues were obtained during nephrectomy from 60 RCC 
      patients. The urine was obtained from both patients and healthy subjects. The 
      findings in RCC tumor tissue compared to healthy renal tissues were following: 
      (i) increases in interleukin-15 (IL-15), vascular endothelial growth factor 
      (VEGF), interferon gamma-induced protein-10 (IP-10), macrophage inflammatory 
      protein-1beta (MIP-1beta), monocyte chemoattractant protein-1 (MCP-1), and eotaxin, 
      with VEGF, IP-10, and MIP-1beta significantly associated with the histologic tumor 
      nuclear grading (NG); (ii) increases in platelet-derived growth factor (PDGF), 
      IL-15, MIP-1ss, eotaxin, and MCP-1 in urine, with significant associations noticed 
      between cytokines and disease stages for eotaxin and MCP-1; and (iii) decreases 
      in PDGF, IL-15, MCP-1, VEGF, MIP-1beta, and eotaxin in urine from six patients on 
      the third day after nephrectomy. We conclude that cytokines may play a critical 
      role in the local pathogenesis of RCC, which opens the way for potential 
      targeting of these molecules in novel therapies and their use as biomarkers for 
      early noninvasive detection of RCC.
CI  - (c) 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.
FAU - Vargova, Daniela
AU  - Vargova D
AUID- ORCID: 0000-0002-7043-0968
AD  - Department of Pharmacology, Jessenius Faculty of Medicine Comenius University, 
      Martin, Slovakia.
FAU - Luptak, Jan
AU  - Luptak J
AUID- ORCID: 0000-0002-9131-7753
AD  - Department of Urology, Jessenius Faculty of Medicine Comenius 
      University/University Hospital, Martin, Slovakia. jan.luptak@uniba.sk.
FAU - Dargaj, Jan
AU  - Dargaj J
AUID- ORCID: 0000-0003-1878-1119
AD  - Department of Urology, Jessenius Faculty of Medicine Comenius 
      University/University Hospital, Martin, Slovakia.
FAU - Franova, Sona
AU  - Franova S
AUID- ORCID: 0000-0001-8429-092X
AD  - Department of Pharmacology, Jessenius Faculty of Medicine Comenius University, 
      Martin, Slovakia.
FAU - Kocmalova, Michaela
AU  - Kocmalova M
AUID- ORCID: 0000-0001-9510-7764
AD  - Department of Pharmacology and Biomedical Center (BioMed Martin), Jessenius 
      Faculty of Medicine Comenius University, Martin, Slovakia.
FAU - Sutovsky, Juraj
AU  - Sutovsky J
AUID- ORCID: 0000-0001-6829-0989
AD  - Clinic of Neurosurgery, Jessenius Faculty of Medicine Comenius 
      University/University Hospital, Martin, Slovakia.
FAU - Svihra, Jan Sr
AU  - Svihra J Sr
AUID- ORCID: 0000-0003-0164-6359
AD  - Department of Urology, Jessenius Faculty of Medicine Comenius 
      University/University Hospital, Martin, Slovakia.
FAU - Skornova, Ingrid
AU  - Skornova I
AUID- ORCID: 0000-0002-8231-0066
AD  - Department of Hematology and Transfusiology, Jessenius Faculty of Medicine 
      Comenius University/University Hospital, Martin, Slovakia.
FAU - Slavik, Pavol
AU  - Slavik P
AUID- ORCID: 0000-0002-7712-8964
AD  - Department of Pathological Anatomy, Jessenius Faculty of Medicine Comenius 
      University/University Hospital, Martin, Slovakia.
FAU - Grendar, Marian
AU  - Grendar M
AUID- ORCID: 0000-0002-6712-3457
AD  - Biomedical Center (BioMed Martin), Jessenius Faculty of Medicine Comenius 
      University, Martin, Slovakia.
FAU - Svihra, Jan Jr
AU  - Svihra J Jr
AUID- ORCID: 0000-0001-6271-0583
AD  - Department of Urology, Jessenius Faculty of Medicine Comenius 
      University/University Hospital, Martin, Slovakia.
FAU - Bris, Lukas
AU  - Bris L
AUID- ORCID: 0000-0002-4299-2410
AD  - Department of Urology, Jessenius Faculty of Medicine Comenius 
      University/University Hospital, Martin, Slovakia.
FAU - Sutovska, Martina
AU  - Sutovska M
AUID- ORCID: 0000-0003-1826-0786
AD  - Department of Pharmacology, Jessenius Faculty of Medicine Comenius University, 
      Martin, Slovakia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Cytokines)
SB  - IM
MH  - *Carcinoma, Renal Cell/diagnosis/surgery
MH  - Case-Control Studies
MH  - *Cytokines/metabolism
MH  - Early Detection of Cancer
MH  - Humans
MH  - *Kidney Neoplasms/diagnosis/pathology/surgery
OTO - NOTNLM
OT  - Biomarkers
OT  - Cytokines
OT  - Nephrectomy
OT  - Nuclear tumor grading
OT  - Renal cell carcinoma
OT  - Targeted therapy
OT  - Tumor tissue
EDAT- 2022/01/18 06:00
MHDA- 2022/04/05 06:00
CRDT- 2022/01/17 12:27
PHST- 2022/01/18 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2022/01/17 12:27 [entrez]
AID - 10.1007/5584_2021_700 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2022;1374:63-72. doi: 10.1007/5584_2021_700.