PMID- 35038474
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 202
DP  - 2022 Mar 31
TI  - A review on lactoferrin as a proton pump inhibitor.
PG  - 309-317
LID - S0141-8130(22)00090-3 [pii]
LID - 10.1016/j.ijbiomac.2022.01.075 [doi]
AB  - Lactoferrin (Lf) is a versatile natural milk-derived protein that exhibits 
      multiple interesting biological activities. Since it is safe for human 
      administration and currently manufactured using low cost and well-established 
      large-scale processes, the Lf scientific community has been devoted at dissecting 
      its mechanisms of action towards its more rational and efficient use for various 
      applications. Emerging literature has identified proton pumping ATPases as 
      molecular targets of Lf in different cellular models linked to distinct 
      activities of this natural protein. Information on this subject has not been 
      systematically analysed before, hence herein we review the current state of art 
      on the effect of Lf on proton pumping ATPases. Though structurally different, we 
      propose that Lf holds a proton pump inhibitor (PPI)-like activity based on the 
      functional resemblance with the classical inhibitors of the stomach 
      H(+)/K(+)-ATPase. The downstream events and outcomes of the PPI-like activity of 
      Lf, as well as its impact for the development of improved Lf applications are 
      also discussed.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Santos-Pereira, Catia
AU  - Santos-Pereira C
AD  - Centre of Molecular and Environmental Biology (CBMA), Department of Biology, 
      University of Minho, 4710-057 Braga, Portugal; CEB - Centre of Biological 
      Engineering, University of Minho, 4710-057 Braga, Portugal; LABBELS - Associate 
      Laboratory, Braga, Guimaraes, Portugal.
FAU - Andres, Maria T
AU  - Andres MT
AD  - Laboratory of Oral Microbiology, University Clinic of Dentistry (CLUO), and 
      Department of Functional Biology (Microbiology), Faculty of Medicine, University 
      of Oviedo, 33006 Oviedo, Asturias, Spain.
FAU - Fierro, Jose F
AU  - Fierro JF
AD  - Laboratory of Oral Microbiology, University Clinic of Dentistry (CLUO), and 
      Department of Functional Biology (Microbiology), Faculty of Medicine, University 
      of Oviedo, 33006 Oviedo, Asturias, Spain.
FAU - Rodrigues, Ligia R
AU  - Rodrigues LR
AD  - CEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, 
      Portugal; LABBELS - Associate Laboratory, Braga, Guimaraes, Portugal.
FAU - Corte-Real, Manuela
AU  - Corte-Real M
AD  - Centre of Molecular and Environmental Biology (CBMA), Department of Biology, 
      University of Minho, 4710-057 Braga, Portugal. Electronic address: 
      mcortereal@bio.uminho.pt.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220115
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Proton Pump Inhibitors)
RN  - EC 3.4.21.- (Lactoferrin)
SB  - IM
MH  - Humans
MH  - *Lactoferrin/pharmacology
MH  - *Proton Pump Inhibitors/pharmacology/therapeutic use
OTO - NOTNLM
OT  - ATPases
OT  - Lactoferrin
OT  - Proton pump inhibitors
EDAT- 2022/01/18 06:00
MHDA- 2022/04/01 06:00
CRDT- 2022/01/17 20:10
PHST- 2021/11/04 00:00 [received]
PHST- 2022/01/11 00:00 [revised]
PHST- 2022/01/11 00:00 [accepted]
PHST- 2022/01/18 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2022/01/17 20:10 [entrez]
AID - S0141-8130(22)00090-3 [pii]
AID - 10.1016/j.ijbiomac.2022.01.075 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2022 Mar 31;202:309-317. doi: 
      10.1016/j.ijbiomac.2022.01.075. Epub 2022 Jan 15.