PMID- 35039897
OWN - NLM
STAT- MEDLINE
DCOM- 20220627
LR  - 20220627
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 481
IP  - 1
DP  - 2022 Jul
TI  - Malignant gastrointestinal neuroectodermal tumor in head and neck: two 
      challenging cases with diverse morphology and different considerations for 
      differential diagnosis.
PG  - 131-136
LID - 10.1007/s00428-022-03274-y [doi]
AB  - Malignant gastrointestinal neuroectodermal tumor (MGNET) is a sarcoma typically 
      involving the gastrointestinal tract with neuroectodermal differentiation and 
      EWSR1-ATF1/CREB1 fusions. Recently, rare MGNET cases were reported in 
      extragastrointestinal sites. We identified 2 cases of MGNET arising in 
      unprecedented laryngeal and intracranial locations, respectively. Both cases 
      showed spindle and epithelioid tumor cells with amphophilic to clear cytoplasm 
      and occasionally prominent nucleoli, arranged in solid, fascicular, and 
      pseudoalveolar patterns. Case 1 exhibited moderate to marked nuclear atypia and 
      focal intraepithelial component. In contrast, case 2 comprised predominantly 
      low-grade epithelioid cells with extensive pseudopapillary structures. Both 
      tumors showed an S100/SOX10-positive and HMB45/melan-A-negative immunoprofile as 
      well as EWSR1-ATF1 fusion. A chief obstacle in diagnosing case 1 was the 
      histologic and immunophenotypic resemblance to melanoma. The striking 
      pseudopapillary architecture and the intracranial location of case 2 rendered 
      differential diagnoses including meningioma and ependymoma. With the peculiar 
      locations and morphology, these cases posed great diagnostic challenge.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Kuo, Chien-Tzu
AU  - Kuo CT
AD  - Department and Graduate Institute of Pathology, National Taiwan University 
      Hospital, National Taiwan University College of Medicine, 7 Chung-Shan South 
      Road, Taipei, 10002, Taiwan.
FAU - Kao, Yu-Chien
AU  - Kao YC
AD  - Department of Pathology, Shuang Ho Hospital, Taipei Medical University, Taipei, 
      Taiwan.
AD  - Department of Pathology, School of Medicine, College of Medicine, Taipei Medical 
      University, Taipei, Taiwan.
FAU - Huang, Hsuan-Ying
AU  - Huang HY
AD  - Department of Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Hsiao, Cheng-Hsiang
AU  - Hsiao CH
AD  - Department of Anatomical Pathology, Cheng-Hsin General Hospital, Taipei, Taiwan.
FAU - Lee, Jen-Chieh
AU  - Lee JC
AUID- ORCID: 0000-0001-7739-5934
AD  - Department and Graduate Institute of Pathology, National Taiwan University 
      Hospital, National Taiwan University College of Medicine, 7 Chung-Shan South 
      Road, Taipei, 10002, Taiwan. leejenchieh@ntuh.gov.tw.
LA  - eng
GR  - NTUH 108-S4295/National Taiwan University Hospital/
PT  - Journal Article
DEP - 20220118
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/genetics
MH  - Diagnosis, Differential
MH  - *Gastrointestinal Neoplasms/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - *Melanoma
OTO - NOTNLM
OT  - ATF1
OT  - Clear cell sarcoma
OT  - EWSR1
OT  - Malignant gastrointestinal neuroectodermal tumor
OT  - Melanoma
EDAT- 2022/01/19 06:00
MHDA- 2022/06/28 06:00
CRDT- 2022/01/18 06:06
PHST- 2021/08/27 00:00 [received]
PHST- 2022/01/09 00:00 [accepted]
PHST- 2021/12/02 00:00 [revised]
PHST- 2022/01/19 06:00 [pubmed]
PHST- 2022/06/28 06:00 [medline]
PHST- 2022/01/18 06:06 [entrez]
AID - 10.1007/s00428-022-03274-y [pii]
AID - 10.1007/s00428-022-03274-y [doi]
PST - ppublish
SO  - Virchows Arch. 2022 Jul;481(1):131-136. doi: 10.1007/s00428-022-03274-y. Epub 
      2022 Jan 18.