PMID- 35040586
OWN - NLM
STAT- MEDLINE
DCOM- 20220418
LR  - 20220418
IS  - 2162-3279 (Electronic)
VI  - 12
IP  - 2
DP  - 2022 Feb
TI  - Is psychological distress associated with carpal tunnel syndrome symptoms and 
      nerve conduction study findings? A case-control study from Syria.
PG  - e2493
LID - 10.1002/brb3.2493 [doi]
LID - e2493
AB  - BACKGROUND: Carpal tunnel syndrome (CTS) is a common entrapment neuropathy of the 
      median nerve at the wrist which causes severe symptoms. However, psychological 
      aspects can affect patients' perception of this pain and can cause similar pain 
      in some instances. This study aims to determine the association between symptoms 
      severity, functional status, and nerve conduction studies (NCS) of adult patients 
      with CTS and their anger, anxiety, and depression status. METHODS: This 
      case-control study was conducted in clinics in Damascus, Syria. Controls were 
      frequency matched by gender and age from a general clinic. Interviews based on 
      questionnaires were used that included the Boston Carpal Tunnel Questionnaire 
      (BCTQ-A), Hospital Anxiety and Depression Scale (HADS), Dimensions of Anger 
      Reactions Scale-5 (DAR-5), and NCS. RESULTS: Overall, 242 patients (121 cases) 
      were included in this study. Cases with CTS had significantly higher anxiety and 
      depression when compared to controls, but not higher anger. Cases with higher 
      anxiety, depression, and anger had significantly more CTS symptoms and less 
      functional status. Anxiety was also higher in cases with normal NCS in the case 
      group. When using regression, anxiety and depression remained significantly 
      associated with having CTS. CONCLUSION: Anxiety and depression are more prominent 
      with CTS. Furthermore, having anxiety and depression were associated with more 
      CTS symptoms in the hand. Having anger was also associated with more CTS symptoms 
      among cases. These findings emphasize the importance of psychological aspects 
      when having hand pain or CTS symptoms as these patients might have these symptoms 
      despite having normal NCS.
CI  - (c) 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Alsharif, Aya
AU  - Alsharif A
AD  - Faculty of Medicine, Damascus University, Damascus, Syria.
AD  - Diagnostic Medical Center - Yaman Daaboul Neurophysiology Clinic, Damascus, 
      Syria.
FAU - Al Habbal, Aya
AU  - Al Habbal A
AD  - Faculty of Medicine, Damascus University, Damascus, Syria.
AD  - Diagnostic Medical Center - Yaman Daaboul Neurophysiology Clinic, Damascus, 
      Syria.
FAU - Daaboul, Yaman
AU  - Daaboul Y
AD  - Diagnostic Medical Center - Yaman Daaboul Neurophysiology Clinic, Damascus, 
      Syria.
FAU - Al Hawat, Lama
AU  - Al Hawat L
AD  - Faculty of Medicine, Damascus University, Damascus, Syria.
FAU - Al Habbal, Osama
AU  - Al Habbal O
AD  - Faculty of Medicine, Damascus University, Damascus, Syria.
FAU - Kakaje, Ameer
AU  - Kakaje A
AUID- ORCID: 0000-0002-3949-6109
AD  - Faculty of Medicine, Damascus University, Damascus, Syria.
AD  - University Hospital Geelong, Barwon Health, Victoria, Australia.
LA  - eng
PT  - Journal Article
DEP - 20220118
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - Adult
MH  - *Carpal Tunnel Syndrome/complications
MH  - Case-Control Studies
MH  - Humans
MH  - Median Nerve
MH  - Neural Conduction/physiology
MH  - Pain/psychology
MH  - *Psychological Distress
MH  - Syria
PMC - PMC8865142
OTO - NOTNLM
OT  - anger
OT  - carpal tunnel syndrome
OT  - functional disability
OT  - nerve conduction studies
OT  - psychological status
OT  - symptom severity
COIS- The authors declare no conflict of interest.
EDAT- 2022/01/19 06:00
MHDA- 2022/04/19 06:00
PMCR- 2022/01/18
CRDT- 2022/01/18 08:56
PHST- 2021/12/22 00:00 [revised]
PHST- 2021/06/29 00:00 [received]
PHST- 2021/12/30 00:00 [accepted]
PHST- 2022/01/19 06:00 [pubmed]
PHST- 2022/04/19 06:00 [medline]
PHST- 2022/01/18 08:56 [entrez]
PHST- 2022/01/18 00:00 [pmc-release]
AID - BRB32493 [pii]
AID - 10.1002/brb3.2493 [doi]
PST - ppublish
SO  - Brain Behav. 2022 Feb;12(2):e2493. doi: 10.1002/brb3.2493. Epub 2022 Jan 18.