PMID- 35041115
OWN - NLM
STAT- MEDLINE
DCOM- 20220523
LR  - 20220523
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 43
IP  - 6
DP  - 2022 Jun
TI  - Serum NfL associated with anti-NMDA receptor encephalitis.
PG  - 3893-3899
LID - 10.1007/s10072-021-05838-3 [doi]
AB  - INTRODUCTION: Neurofilament light chains (NfL) have been reported as potential 
      markers for neuronal-axonal injury in neuroinflammatory diseases. In the current 
      study, we describe serum NfL levels as a prognostic marker for 
      anti-N-methyl-D-aspartate receptor encephalitis (NMDARE). METHODS: Serum levels 
      of NfL of 64 patients with anti-NMDARE and 84 healthy controls were measured by 
      Simoa. The anti-NMDAR Encephalitis One-Year Functional Status (NEOS) score, 
      Modified Rankin Scale (mRS) scores, and clinical and cerebrospinal fluid 
      parameters were evaluated in patients with anti-NMDARE. Meanwhile, we performed a 
      receiver-operator characteristic analysis to assess the power of the serum NFL in 
      predicting the 1-year functional status. RESULTS: Serum NfL levels were 
      significantly elevated in patients with anti-NMDARE compared to healthy controls 
      (p < 0.001, p(adjusted) < 0.001), especially in patients with severe impairments 
      (mRS > 3 vs </= 3, p = 0.035) or with limited response to treatment (vs. favorable 
      outcome, p = 0.011). Serum NFL was positively associated with the initial 
      admission mRS (r = 0.23, p = 0.072) and 1-year mRS (r = 0.29, p = 0.018). The AUC 
      of serum NfL and NEOS score for 1-year poor functional status was 0.697 (95% CI 
      0.527-0.866, p = 0.011), 0.753 (95% CI 0.616-0.890, p = 0.001), respectively. 
      Furthermore, AUC of the combination of serum NfL and NEOS was 0.815 (95% CI 
      0.680-0.950, p < 0.001). CONCLUSION: Our findings show that serum NfL levels 
      evaluated in anti-NMDAR encephalitis may be a good predictor of the risk of 
      1-year poor functional status.
CI  - (c) 2022. Fondazione Societa Italiana di Neurologia.
FAU - Ma, Xiaoyu
AU  - Ma X
AD  - Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Lu, Yaxin
AU  - Lu Y
AD  - Department of Clinical Data Center, The Third Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, China.
FAU - Peng, Fuhua
AU  - Peng F
AD  - Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Wang, Yuge
AU  - Wang Y
AD  - Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Sun, Xiaobo
AU  - Sun X
AD  - Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Luo, Wenjing
AU  - Luo W
AD  - Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Shen, Shishi
AU  - Shen S
AD  - Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Liu, Zifeng
AU  - Liu Z
AD  - Department of Clinical Data Center, The Third Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, China.
FAU - Kermode, Allan G
AU  - Kermode AG
AD  - Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China.
AD  - Centre for Neuromuscular and Neurological Disorders, University of Western 
      Australia, Department of Neurology, Sir Charles Gairdner Hospital, Queen 
      Elizabeth II Medical Centre, Perth, Australia.
AD  - Institute of Immunology and Infectious Diseases, Murdoch University, Perth, 
      Australia.
FAU - Qiu, Wei
AU  - Qiu W
AD  - Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China. qiuwei120@vip.163.com.
FAU - Shu, Yaqing
AU  - Shu Y
AUID- ORCID: 0000-0003-2768-1654
AD  - Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China. shuyaq@mail.sysu.edu.cn.
LA  - eng
GR  - 2021A1515010393/Natural Science Foundation of Guangdong Province/
GR  - 82071343/National Natural Science Foundation of China/
GR  - 81701188/National Natural Science Foundation of China/
GR  - P02099/First Major Talent Project of the Third Affiliated Hospital of Sun Yat-sen 
      University/
PT  - Journal Article
DEP - 20220118
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (Biomarkers)
SB  - IM
MH  - *Anti-N-Methyl-D-Aspartate Receptor Encephalitis/therapy
MH  - Biomarkers
MH  - Humans
OTO - NOTNLM
OT  - Anti-N-methyl-D-aspartate receptor encephalitis
OT  - Neurofilament light chain
OT  - Prognosis
EDAT- 2022/01/19 06:00
MHDA- 2022/05/24 06:00
CRDT- 2022/01/18 12:41
PHST- 2021/11/12 00:00 [received]
PHST- 2021/12/16 00:00 [accepted]
PHST- 2022/01/19 06:00 [pubmed]
PHST- 2022/05/24 06:00 [medline]
PHST- 2022/01/18 12:41 [entrez]
AID - 10.1007/s10072-021-05838-3 [pii]
AID - 10.1007/s10072-021-05838-3 [doi]
PST - ppublish
SO  - Neurol Sci. 2022 Jun;43(6):3893-3899. doi: 10.1007/s10072-021-05838-3. Epub 2022 
      Jan 18.