PMID- 35042215
OWN - NLM
STAT- MEDLINE
DCOM- 20220603
LR  - 20220924
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 183
IP  - 6
DP  - 2022
TI  - Development of Sensitization to Multiple Allergen Molecules from Preschool to 
      School Age Is Related to Asthma.
PG  - 628-639
LID - 10.1159/000521324 [doi]
AB  - INTRODUCTION: Allergic sensitization in early life has been identified as a 
      strong risk factor for subsequent asthma in childhood. It is still unclear why 
      only a part of sensitized children develop asthma, and the role of specific 
      allergen molecules in asthma pathogenesis is ambiguous [Pharmacol Ther. 2009 
      Feb;121(2):174-84]. We assessed the sensitization to multiple allergen molecules 
      longitudinally and explored its relation to persistent asthma at 7 years. 
      METHODS: Seventy-two children included during an acute wheezing episode (cases) 
      were followed prospectively from early preschool age (EPA) to age 7, and compared 
      to 43 healthy controls at EPA. Allergen molecules were analyzed at EPA and age 7 
      using ImmunoCAP Solid-phase Allergen Chip (ISAC). Asthma diagnosis at 7 years was 
      based on symptoms, medication, and spirometry. RESULTS: At EPA, cases compared to 
      controls showed a tendency toward having a higher prevalence of allergic 
      sensitization (23.6% vs. 9.3%, p = 0.055). The prevalence of sensitization 
      increased in cases from EPA to 7 years (23.6% vs. 38.9%; p = 0.048) as well as 
      the median number (range) of immunoglobulin E (IgE)-reactive molecules 3 (3-14) 
      versus 6.5 (1-21); p = 0.024. Sensitization to each additional molecule from EPA 
      to the age of 7 was significantly related to asthma at 7 (OR = 1.25, 95% 
      confidence interval [1.01, 1.54]). CONCLUSION: Polysensitization, assessed by 
      allergen molecules, had a significant impact on persistent asthma at school age. 
      The extent of sensitization, illustrated by molecular spreading from preschool to 
      school age, was related to asthma diagnosis at 7 years in children with a history 
      of wheezing at early life.
CI  - (c) 2022 The Author(s). Published by S. Karger AG, Basel.
FAU - Filiou, Anastasia
AU  - Filiou A
AD  - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 
      Sweden.
AD  - Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm, 
      Sweden.
FAU - Holmdahl, Idun
AU  - Holmdahl I
AD  - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 
      Sweden.
AD  - Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm, 
      Sweden.
FAU - Asarnoj, Anna
AU  - Asarnoj A
AD  - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 
      Sweden.
AD  - Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm, 
      Sweden.
FAU - van Hage, Marianne
AU  - van Hage M
AD  - Division of Immunology and Allergy, Department of Medicine Solna, Karolinska 
      Institutet and Karolinska University Hospital, Stockholm, Sweden.
FAU - Ekenkrantz, Tina
AU  - Ekenkrantz T
AD  - Thermo Fisher Scientific, Uppsala, Sweden.
FAU - Rydell, Niclas
AU  - Rydell N
AD  - Thermo Fisher Scientific, Uppsala, Sweden.
FAU - Sjolander, Anders
AU  - Sjolander A
AD  - Thermo Fisher Scientific, Uppsala, Sweden.
FAU - Stenberg-Hammar, Katarina
AU  - Stenberg-Hammar K
AD  - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 
      Sweden.
AD  - Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm, 
      Sweden.
FAU - Hedlin, Gunilla
AU  - Hedlin G
AD  - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 
      Sweden.
AD  - Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm, 
      Sweden.
FAU - Konradsen, Jon R
AU  - Konradsen JR
AD  - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 
      Sweden.
AD  - Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm, 
      Sweden.
FAU - Soderhall, Cilla
AU  - Soderhall C
AD  - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 
      Sweden.
AD  - Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm, 
      Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220118
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Allergens
MH  - *Asthma/diagnosis/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Immunoglobulin E
MH  - Respiratory Sounds
MH  - Spirometry
PMC - PMC9227676
OTO - NOTNLM
OT  - Allergen molecules
OT  - Allergic sensitization
OT  - Asthma
OT  - Longitudinal
OT  - Polysensitization
OT  - Preschool wheeze
COIS- Anastasia Eleni Filiou, Idun Holmdahl, Anna Asarnoj, Katarina Stenberg-Hammar, 
      and Gunilla Hedlin have no conflicts of interest to declare. Marianne van Hage 
      reports personal fees from Thermo Fisher Scientific, outside the submitted work. 
      Niclas Rydell, Tina Ekencrantz, and Anders Sjolander are employees of Thermo 
      Fisher Scientific. Dr Konradsen and Dr. Soderhall report nonfinancial support 
      from Thermo Fisher Scientific, during the conduct of the study.
EDAT- 2022/01/19 06:00
MHDA- 2022/06/07 06:00
PMCR- 2022/01/18
CRDT- 2022/01/18 20:28
PHST- 2021/09/24 00:00 [received]
PHST- 2021/11/12 00:00 [accepted]
PHST- 2022/01/19 06:00 [pubmed]
PHST- 2022/06/07 06:00 [medline]
PHST- 2022/01/18 20:28 [entrez]
PHST- 2022/01/18 00:00 [pmc-release]
AID - 000521324 [pii]
AID - iaa-0183-0628 [pii]
AID - 10.1159/000521324 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2022;183(6):628-639. doi: 10.1159/000521324. Epub 2022 
      Jan 18.