PMID- 35042317
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220716
IS  - 1998-4049 (Electronic)
IS  - 1319-3767 (Print)
IS  - 1319-3767 (Linking)
VI  - 28
IP  - 3
DP  - 2022 May-Jun
TI  - Serum levels of soluble HLA-G correlate with disease activity in pediatric 
      patients with Crohn's disease.
PG  - 233-238
LID - 10.4103/sjg.sjg_327_21 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA)-G, a member of the HLA family, is 
      crucial for fetomaternal tolerance. Transmembrane or circulating/soluble HLA-G 
      (sHLA-G) is elevated in autoimmune conditions and the tumor microenvironment. 
      Circulating sHLA-G levels and their association with disease activity have not 
      yet been assessed in pediatric patients with inflammatory bowel disease (IBD). 
      This study aimed to quantify the serum sHLA-G levels of pediatric patients with 
      IBD and assess the association of serum sHLA-G with disease activity. METHODS: : 
      We enrolled 24 pediatric IBD patients Crohn's disease (CD) and ulcerative colitis 
      (UC), n = 12 each] and 24 healthy controls. Based on the disease activity index, 
      five and seven of the CD patients had mild and moderate/severe disease, 
      respectively, whereas six of the UC patients were in remission and six had mild 
      disease. Serum was collected and sHLA-G levels were determined by enzyme-linked 
      immunosorbent assay (ELISA). RESULTS: : Pediatric patients with CD had 
      significantly higher sHLA-G levels compared with patients with UC and healthy 
      controls. Notably, serum sHLA-G levels were significantly higher in patients with 
      moderate/severe CD than in those with mild CD. CONCLUSIONS: : Serum sHLA-G levels 
      correlate with disease activity in pediatric patients with CD and are higher in 
      CD patients than in UC patients. Thus, sHLA-G is a potential biomarker for 
      disease activity in CD.
FAU - Cansever, Murat
AU  - Cansever M
AD  - Department of Pediatrics, Division of Immunology, School of Medicine, Erciyes 
      University, Kayseri, Turkey.
FAU - Goktas, Mehmet Akif
AU  - Goktas MA
AD  - Department of Pediatrics, Division of Gastroenterology, School of Medicine, 
      Hacettepe University, Kayseri, Turkey.
FAU - Arslan, Duran
AU  - Arslan D
AD  - Department of Pediatrics, Division of Gastroenterology, School of Medicine, 
      Erciyes University, Kayseri, Turkey.
FAU - Patiroglu, Turkan
AU  - Patiroglu T
AD  - Department of Pediatrics, Division of Immunology, School of Medicine, Erciyes 
      University, Kayseri, Turkey.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Saudi J Gastroenterol
JT  - Saudi journal of gastroenterology : official journal of the Saudi 
      Gastroenterology Association
JID - 9516979
RN  - 0 (HLA-G Antigens)
RN  - Pediatric Crohn's disease
SB  - IM
MH  - Child
MH  - *Colitis, Ulcerative
MH  - *Crohn Disease/pathology
MH  - HLA-G Antigens
MH  - Humans
MH  - *Inflammatory Bowel Diseases
PMC - PMC9212116
OTO - NOTNLM
OT  - Crohn's disease
OT  - HLA-G antigens
OT  - ulcerative colitis
COIS- None
EDAT- 2022/01/20 06:00
MHDA- 2022/05/18 06:00
PMCR- 2022/01/12
CRDT- 2022/01/19 01:53
PHST- 2022/01/20 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/01/19 01:53 [entrez]
PHST- 2022/01/12 00:00 [pmc-release]
AID - 335633 [pii]
AID - SJG-28-233 [pii]
AID - 10.4103/sjg.sjg_327_21 [doi]
PST - ppublish
SO  - Saudi J Gastroenterol. 2022 May-Jun;28(3):233-238. doi: 10.4103/sjg.sjg_327_21.