PMID- 35042559
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231105
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 14
IP  - 1
DP  - 2022 Jan 18
TI  - Fibrinogen function indexes are potential biomarkers of diabetic peripheral 
      neuropathy.
PG  - 13
LID - 10.1186/s13098-021-00777-7 [doi]
LID - 13
AB  - BACKGROUND AND OBJECTIVES: Research suggests that diabetic peripheral neuropathy 
      (DPN) is related to plasma fibrinogen (Fib) concentrations, although its 
      correlation with Fib function has not been reported. Here, the k value and angle 
      alpha, reflecting the plasma Fib function, were used to analyse its correlation with 
      DPN, and their potential as biological indicators for diagnosing DPN was 
      explored. SUBJECTS AND METHODS: This prospective observational clinical study 
      enrolled 561 type 2 diabetes mellitus (T2DM) patients, who were divided into the 
      diabetes with symptomatic neuropathy (161 cases), diabetes with asymptomatic 
      neuropathy (132 cases) and diabetes with no neuropathy (268 cases) groups. 
      Meanwhile, 160 healthy unrelated subjects were recruited as controls. RESULTS: 
      Fib levels increased slightly in diabetic subjects with neuropathy compared with 
      those without. The angle alpha levels increased slightly in subjects with 
      asymptomatic DPN compared with those with no neuropathy and increased greatly in 
      subjects with symptomatic DPN compared with those without. The k value levels 
      slightly decreased in subjects with asymptomatic DPN compared with those with no 
      neuropathy and greatly decreased in subjects with symptomatic DPN compared with 
      those without. The association of the k value and angle alpha with diabetic 
      neuropathy was independent of the hyperglycaemic state and other potential 
      confounders (odds ratio 0.080 [0.051-0.124], P < 0.001; odds ratio 1.131 
      [1.063-1.204], P < 0.001). The k value and angle alpha levels were closely correlated 
      with neuropathy stage (r  = - 0.686, P < 0.000; r  = 0.314, P < 0.001). The 
      optimal cut-off point for k value levels to distinguish patients with diabetic 
      neuropathy from those without was 1.8 min, with a sensitivity of 73.7% and a 
      specificity of 83.2% (AUC = 0.873). The optimal cut-off point for angle alpha levels 
      was 60 degrees , with a sensitivity of 41.0% and a specificity of 95.6% (AUC = 0.669). 
      CONCLUSIONS: The k value and angle alpha are closely associated with DPN. The levels 
      of the k value and angle alpha may be helpful in the early diagnosis of DPN.
CI  - (c) 2022. The Author(s).
FAU - Zhuang, Yong
AU  - Zhuang Y
AD  - Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, 362000, China.
FAU - Lin, Xiahong
AU  - Lin X
AUID- ORCID: 0000-0001-8445-818X
AD  - Department of Endocrinology, The Seventh Affiliated Hospital of Sun Yat-sen 
      University, No. 950 Donghai Street, Fengze District, Quanzhou City, 518000, 
      Fujian, China. 15880319253@139.com.
FAU - Chen, Xiaoyu
AU  - Chen X
AD  - Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, 362000, China.
FAU - Wu, Xiaohong
AU  - Wu X
AD  - Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, 362000, China.
FAU - Zhang, Jinying
AU  - Zhang J
AD  - Department of Neurology, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, 362000, China.
LA  - eng
GR  - 2020QH1118/Startup Fund for scientific research, Fujian Medical University/
PT  - Journal Article
DEP - 20220118
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC8764774
OTO - NOTNLM
OT  - Angle alpha
OT  - Diabetic peripheral neuropathy
OT  - Diagnosis
OT  - Fibrinogen
OT  - k value
COIS- No potential conflicts of interest relevant to this article were reported.
EDAT- 2022/01/20 06:00
MHDA- 2022/01/20 06:01
PMCR- 2022/01/18
CRDT- 2022/01/19 05:49
PHST- 2021/10/15 00:00 [received]
PHST- 2021/12/28 00:00 [accepted]
PHST- 2022/01/19 05:49 [entrez]
PHST- 2022/01/20 06:00 [pubmed]
PHST- 2022/01/20 06:01 [medline]
PHST- 2022/01/18 00:00 [pmc-release]
AID - 10.1186/s13098-021-00777-7 [pii]
AID - 777 [pii]
AID - 10.1186/s13098-021-00777-7 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2022 Jan 18;14(1):13. doi: 10.1186/s13098-021-00777-7.