PMID- 35043051
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220430
IS  - 1726-913X (Print)
IS  - 1726-9148 (Electronic)
IS  - 1726-913X (Linking)
VI  - 19
IP  - 4
DP  - 2021 Oct
TI  - Anthropometric Indices and Age at Natural Menopause: A 15-Year Follow-up 
      Population-Based Study.
PG  - e109285
LID - 10.5812/ijem.109285 [doi]
LID - e109285
AB  - BACKGROUND: Following menopause, the risk of many diseases is increased, and this 
      situation may be due to changes in anthropometric indices (AI), while the 
      association between adiposity and age at natural menopause (ANM) is not clear 
      yet. OBJECTIVES: This longitudinal study was conducted to investigate the ability 
      of AI in predicting ANM. METHODS: For this purpose, a total of 3,876 women aged > 
      20 years old from participants of the Tehran lipid and glucose study (TLGS) met 
      our eligibility criteria. The association between ANM and various AIs was 
      assessed using the Accelerated Failure Time (AFT) model, and time ratio (TR) with 
      95% confidence intervals was reported in this longitudinal study. RESULTS: The 
      median [interquartile range (IQR) 25 - 75] of the survival time was 12.5 (7.9 - 
      15.8) years. At the end of the follow-up, 1,479 (38.2%) of the participants 
      reached menopause. The median time to natural menopause was decreased by about 2% 
      with one standard deviation (SD) increase of both a body shape index (ABSI) (time 
      ratio (TR): 0.98, 95% CI: 0.97, 0.99) and lipid accumulation product (LAP) (TR: 
      0.98, 95% CI: 0.98, 0.99) z-scores; and this time was increased by about 1% (TR: 
      1.01, 95% CI: 1.00, 1.02) with one SD increase in body mass index (BMI) z-score. 
      CONCLUSIONS: The ABSI, LAP, and BMI were the most useful AIs for identification 
      of the time to menopause onset, and ABSI and LAP were inversely associated with 
      the ANM. Also, the BMI was directly associated with the ANM.
CI  - Copyright (c) 2021, International Journal of Endocrinology and Metabolism.
FAU - Farahmand, Maryam
AU  - Farahmand M
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Ramezani Tehrani, Fahimeh
AU  - Ramezani Tehrani F
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Rahmati, Maryam
AU  - Rahmati M
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Azizi, Fereidoun
AU  - Azizi F
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20210805
PL  - Netherlands
TA  - Int J Endocrinol Metab
JT  - International journal of endocrinology and metabolism
JID - 101235597
PMC - PMC8761485
OTO - NOTNLM
OT  - Anthropometry
OT  - Menopause
OT  - Obesity
COIS- Conflict of Interests: The authors declare that there is no conflict of interest.
EDAT- 2022/01/20 06:00
MHDA- 2022/01/20 06:01
PMCR- 2021/10/01
CRDT- 2022/01/19 06:57
PHST- 2020/09/09 00:00 [received]
PHST- 2021/02/02 00:00 [revised]
PHST- 2021/04/19 00:00 [accepted]
PHST- 2022/01/19 06:57 [entrez]
PHST- 2022/01/20 06:00 [pubmed]
PHST- 2022/01/20 06:01 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - 10.5812/ijem.109285 [doi]
PST - epublish
SO  - Int J Endocrinol Metab. 2021 Aug 5;19(4):e109285. doi: 10.5812/ijem.109285. 
      eCollection 2021 Oct.