PMID- 35043365
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20220412
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 45
IP  - 5
DP  - 2022 May
TI  - Maternal hyperandrogenism is associated with a higher risk of type 2 diabetes 
      mellitus and overweight in adolescent and adult female offspring: a long-term 
      population-based follow-up study.
PG  - 963-972
LID - 10.1007/s40618-021-01721-2 [doi]
AB  - PURPOSE: Adverse intrauterine environment may predispose offspring to 
      cardio-metabolic dysfunction in later life. In this study, we aimed to 
      investigate the effects of maternal hyperandrogenism (MH) on cardio-metabolic 
      risk factors in female offspring in later life. METHODS: This prospective 
      population-based study included 211 female offspring with MH and 757 female 
      offspring without MH (controls). Both groups were followed from baseline to the 
      date of incidence of events, censoring, or end of the study period, whichever 
      came first. Age scaled unadjusted and adjusted cox regression models were applied 
      to assess the hazard ratios (HR) and 95% confidence intervals (CIs) for the 
      association of MH with pre-diabetes (pre-DM), type 2 diabetes mellitus (T2DM), 
      overweight and obesity in offspring of both groups. Statistical analysis was 
      performed using the software package STATA; significance level was set at 
      P < 0.05. RESULTS: This study revealed a higher risk of T2DM (unadjusted HR 2.67, 
      95% CI 1.33-5.36) and overweight (unadjusted HR 1.41, 95% CI 1.06-1.88) in female 
      offspring with MH, compared to controls. Results remained unchanged after 
      adjustment for potential confounders including body mass index, education, 
      physical activity, mother's age at delivery, birth weight, and childhood obesity. 
      However, no significant difference was observed in the risk of pre-DM and obesity 
      in females with MH, compared to controls in both unadjusted and adjusted models. 
      CONCLUSION: This pioneer study with a long-term follow-up demonstrated that MH 
      increases the risk of developing T2DM and being overweight in female offspring in 
      later life. Further long-term population-based studies are needed to confirm 
      these findings.
CI  - (c) 2021. Italian Society of Endocrinology (SIE).
FAU - Noroozzadeh, M
AU  - Noroozzadeh M
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, 23 Parvaneh, Yaman 
      Street, Velenjak, Tehran, 1985717413, Iran.
FAU - Rahmati, M
AU  - Rahmati M
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, 23 Parvaneh, Yaman 
      Street, Velenjak, Tehran, 1985717413, Iran.
FAU - Behboudi-Gandevani, S
AU  - Behboudi-Gandevani S
AD  - Faculty of Nursing and Health Sciences, Nord University, Bodo, Norway.
FAU - Ramezani Tehrani, F
AU  - Ramezani Tehrani F
AUID- ORCID: 0000-0002-4609-065X
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, 23 Parvaneh, Yaman 
      Street, Velenjak, Tehran, 1985717413, Iran. ramezani@endocrine.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20220119
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Body Mass Index
MH  - Child
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - *Diabetes, Gestational/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Hyperandrogenism/epidemiology/etiology
MH  - Overweight/complications/epidemiology
MH  - *Pediatric Obesity
MH  - *Prediabetic State
MH  - Pregnancy
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Maternal hyperandrogenism
OT  - Obesity
OT  - Overweight
OT  - Pre-diabetes (pre-DM)
OT  - Type 2 diabetes mellitus (T2DM)
EDAT- 2022/01/20 06:00
MHDA- 2022/04/13 06:00
CRDT- 2022/01/19 07:07
PHST- 2021/09/18 00:00 [received]
PHST- 2021/12/06 00:00 [accepted]
PHST- 2022/01/20 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
PHST- 2022/01/19 07:07 [entrez]
AID - 10.1007/s40618-021-01721-2 [pii]
AID - 10.1007/s40618-021-01721-2 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2022 May;45(5):963-972. doi: 10.1007/s40618-021-01721-2. 
      Epub 2022 Jan 19.