PMID- 35043408
OWN - NLM
STAT- MEDLINE
DCOM- 20220419
LR  - 20220509
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 94
IP  - 6
DP  - 2022 Jun
TI  - Environmental risk factors and genetic markers of Kaposi's sarcoma-associated 
      herpesvirus infection among Uygur population in Xinjiang, China.
PG  - 2755-2765
LID - 10.1002/jmv.27600 [doi]
AB  - Kaposi sarcoma-associated herpesvirus (KSHV) is endemic in Xinjiang, China. 
      Determinants of KSHV seropositivity among high-risk groups are not well 
      understood. We seek to identify genetic and environmental predisposing factors 
      for KSHV infection among Uygurs in this endemic region. A cross-sectional study 
      was performed among the Uygur population in Xinjiang, China. KSHV-antibodies were 
      detected using immunofluorescence assay (IFA) and human leukocyte antigen (HLA) 
      alleles were genotyped. Univariate and multivariate logistic regression analyses 
      were applied to explore the environmental and genetic risk factors of KSHV 
      seropositivity. Finally, a total of 721 participants were included. The 
      seroprevalence of KSHV was 24.1% among this population. Sweet-food preference 
      (odds ratio [OR] 1.85, 95% confidence interval [CI] 1.03-3.34), and coronary 
      heart disease (OR 1.91, 95%CI 1.24-2.94) were statistically correlated with KSHV 
      infection. HLA-DQB1*06:09 were found to significantly increase the risk of KSHV 
      infection under all 3 models (OR(Allelic)  = 4.06; OR(Dominant)  = 3.27; and 
      OR(Recessive)  = 8.06). Six SNPs (SNP0260, SNP0361, SNP0797, SNP0852, SNP1159, 
      and SNP1375) in the DQB1 and DRB1 region and haploid type GTCTAACTAATC in block 
      17 were statistically associated with KSHV infection. We demonstrated that 
      genetic variations in HLA-DQB1/DRB1 and environmental risk factors were strongly 
      associated with KSHV infection among this population.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Shanghai Institute of Infectious Disease and Biosecurity, School of Public 
      Health, Fudan University, Shanghai, China.
AD  - Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, 
      Shanghai, China.
FAU - Fang, Qiwen
AU  - Fang Q
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Shanghai Institute of Infectious Disease and Biosecurity, School of Public 
      Health, Fudan University, Shanghai, China.
AD  - Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, 
      Shanghai, China.
FAU - Zhu, Sibo
AU  - Zhu S
AD  - State Key Laboratory of Genetic Engineering and Collaborative Innovation Center 
      for Genetics and Development, School of Life Sciences, Fudan University, 
      Shanghai, China.
FAU - Wu, Xuefu
AU  - Wu X
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, 
      Shanghai, China.
FAU - Yuan, Huangbo
AU  - Yuan H
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, 
      Shanghai, China.
AD  - State Key Laboratory of Genetic Engineering and Collaborative Innovation Center 
      for Genetics and Development, School of Life Sciences, Fudan University, 
      Shanghai, China.
FAU - Liu, Zhenqiu
AU  - Liu Z
AD  - State Key Laboratory of Genetic Engineering and Collaborative Innovation Center 
      for Genetics and Development, School of Life Sciences, Fudan University, 
      Shanghai, China.
FAU - Xu, Yiyun
AU  - Xu Y
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, 
      Shanghai, China.
FAU - Chen, Tao
AU  - Chen T
AD  - Department of HIV/AIDS prevention and control, Xinjiang Ili Center for Diseases 
      Control and Prevention, Xinjiang, China.
FAU - Zeng, Yan
AU  - Zeng Y
AD  - Department of Biochemistry, Key Laboratory of Xinjiang Endemic and Ethnic Disease 
      and School of Medicine, Shihezi University, Shihezi, Xinjiang, China.
FAU - Zhang, Tiejun
AU  - Zhang T
AUID- ORCID: 0000-0002-5187-7393
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Shanghai Institute of Infectious Disease and Biosecurity, School of Public 
      Health, Fudan University, Shanghai, China.
AD  - Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, 
      Shanghai, China.
AD  - Yiwu Research Institue, Fudan University, Yiwu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220126
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Genetic Markers)
SB  - IM
MH  - *Acquired Immunodeficiency Syndrome
MH  - Cross-Sectional Studies
MH  - Genetic Markers
MH  - *Herpesviridae Infections/epidemiology
MH  - *Herpesvirus 8, Human/genetics
MH  - Humans
MH  - Risk Factors
MH  - *Sarcoma, Kaposi/epidemiology/genetics
MH  - Seroepidemiologic Studies
OTO - NOTNLM
OT  - Kaposi's sarcoma-associated herpesvirus
OT  - human leukocyte antigen
OT  - risk factors
EDAT- 2022/01/20 06:00
MHDA- 2022/04/20 06:00
CRDT- 2022/01/19 07:09
PHST- 2022/01/07 00:00 [revised]
PHST- 2021/11/17 00:00 [received]
PHST- 2022/01/16 00:00 [accepted]
PHST- 2022/01/20 06:00 [pubmed]
PHST- 2022/04/20 06:00 [medline]
PHST- 2022/01/19 07:09 [entrez]
AID - 10.1002/jmv.27600 [doi]
PST - ppublish
SO  - J Med Virol. 2022 Jun;94(6):2755-2765. doi: 10.1002/jmv.27600. Epub 2022 Jan 26.