PMID- 35043965
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20220407
IS  - 1465-3664 (Electronic)
IS  - 0142-6338 (Linking)
VI  - 68
IP  - 1
DP  - 2022 Jan 7
TI  - High Serum Total IgE at Admission Is Associated with Coronary Artery Lesions in 
      Children with Kawasaki Disease.
LID - fmab113 [pii]
LID - 10.1093/tropej/fmab113 [doi]
AB  - Kawasaki disease (KD) is associated with allergy. As immunoglobulin E (IgE), a 
      key element of allergic reactions, is related with coronary heart disease, we 
      evaluated the serum total IgE levels, and investigated its clinical relevance in 
      339 children with KD. These patients were classified as high IgE group and normal 
      IgE group according to the reference value of IgE. Serum IgE levels in the high 
      group (279.76 +/- 202.54 IU/mL) significantly increased compared with the normal 
      group (5.51 +/- 15.79 IU/mL) (p < 0.001). There were also no significant 
      differences in the frequency of major clinical manifestation between the two 
      groups. The number of patients who developed coronary artery lesions (CALs) was 
      significantly higher in the high group (p = 0.004), and the serum levels of IgE 
      were also markedly higher in the KD patients with CALs than in patients without 
      CALs (p = 0.002). High total serum IgE was an independent prognostic for CALs in 
      the multivariate analysis. In conclusion, serum IgE levels may be associated with 
      CALs in children with KD.
CI  - (c) The Author(s) [2022]. Published by Oxford University Press. All rights 
      reserved. For permissions, please email: journals.permissions@oup.com.
FAU - Wang, Zhi
AU  - Wang Z
AD  - Department of Rheumatology, Jiangxi Province Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
AD  - Department of Rheumatology, The Affiliated Children's Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
FAU - Liu, Xiaohui
AU  - Liu X
AD  - Department of Rheumatology, Jiangxi Province Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
AD  - Department of Rheumatology, The Affiliated Children's Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
FAU - Duan, Zhao
AU  - Duan Z
AD  - Department of Rheumatology, Jiangxi Province Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
AD  - Department of Rheumatology, The Affiliated Children's Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
FAU - Peng, Yu
AU  - Peng Y
AUID- ORCID: 0000-0002-4623-8829
AD  - Department of Rheumatology, Jiangxi Province Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
AD  - Department of Rheumatology, The Affiliated Children's Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Trop Pediatr
JT  - Journal of tropical pediatrics
JID - 8010948
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - *Coronary Artery Disease/etiology
MH  - Humans
MH  - Immunoglobulin E
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Infant
MH  - *Mucocutaneous Lymph Node Syndrome/complications/diagnosis
OTO - NOTNLM
OT  - IgE
OT  - Kawasaki disease
OT  - coronary artery lesions
EDAT- 2022/01/20 06:00
MHDA- 2022/04/08 06:00
CRDT- 2022/01/19 08:54
PHST- 2022/01/19 08:54 [entrez]
PHST- 2022/01/20 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
AID - 6511395 [pii]
AID - 10.1093/tropej/fmab113 [doi]
PST - ppublish
SO  - J Trop Pediatr. 2022 Jan 7;68(1):fmab113. doi: 10.1093/tropej/fmab113.