PMID- 35044505
OWN - NLM
STAT- MEDLINE
DCOM- 20220620
LR  - 20230114
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Print)
IS  - 0721-832X (Linking)
VI  - 260
IP  - 7
DP  - 2022 Jul
TI  - Automated foveal location detection on spectral-domain optical coherence 
      tomography in geographic atrophy patients.
PG  - 2261-2270
LID - 10.1007/s00417-021-05520-6 [doi]
AB  - PURPOSE: To develop a fully automated algorithm for accurate detection of fovea 
      location in atrophic age-related macular degeneration (AMD), based on 
      spectral-domain optical coherence tomography (SD-OCT) scans. METHODS: Image 
      processing was conducted on a cohort of patients affected by geographic atrophy 
      (GA). SD-OCT images (cube volume) from 55 eyes (51 patients) were extracted and 
      processed with a layer segmentation algorithm to segment Ganglion Cell Layer 
      (GCL) and Inner Plexiform Layer (IPL). Their en face thickness projection was 
      convolved with a 2D Gaussian filter to find the global maximum, which 
      corresponded to the detected fovea. The detection accuracy was evaluated by 
      computing the distance between manual annotation and predicted location. RESULTS: 
      The mean total location error was 0.101+/-0.145mm; the mean error in horizontal and 
      vertical en face axes was 0.064+/-0.140mm and 0.063+/-0.060mm, respectively. The mean 
      error for foveal and extrafoveal retinal pigment epithelium and outer retinal 
      atrophy (RORA) was 0.096+/-0.070mm and 0.107+/-0.212mm, respectively. Our method 
      obtained a significantly smaller error than the fovea localization algorithm 
      inbuilt in the OCT device (0.313+/-0.283mm, p <.001) or a method based on the 
      thinnest central retinal thickness (0.843+/-1.221, p <.001). Significant outliers 
      are depicted with the reliability score of the method. CONCLUSION: Despite 
      retinal anatomical alterations related to GA, the presented algorithm was able to 
      detect the foveal location on SD-OCT cubes with high reliability. Such an 
      algorithm could be useful for studying structural-functional correlations in 
      atrophic AMD and could have further applications in different retinal 
      pathologies.
CI  - (c) 2021. The Author(s).
FAU - Montesel, Andrea
AU  - Montesel A
AD  - Department of Ophthalmology, Fondation Asile des Aveugles, Jules Gonin Eye 
      Hospital, University of Lausanne, 15 Avenue de France, CP 5143, CH-1004, 
      Lausanne, Switzerland.
FAU - Gigon, Anthony
AU  - Gigon A
AD  - Department of Ophthalmology, Fondation Asile des Aveugles, Jules Gonin Eye 
      Hospital, University of Lausanne, 15 Avenue de France, CP 5143, CH-1004, 
      Lausanne, Switzerland.
FAU - Mosinska, Agata
AU  - Mosinska A
AD  - RetinAI Medical AG, Bern, Switzerland.
FAU - Apostolopoulos, Stefanos
AU  - Apostolopoulos S
AD  - RetinAI Medical AG, Bern, Switzerland.
FAU - Ciller, Carlos
AU  - Ciller C
AD  - RetinAI Medical AG, Bern, Switzerland.
FAU - De Zanet, Sandro
AU  - De Zanet S
AD  - RetinAI Medical AG, Bern, Switzerland.
FAU - Mantel, Irmela
AU  - Mantel I
AUID- ORCID: 0000-0002-8822-8194
AD  - Department of Ophthalmology, Fondation Asile des Aveugles, Jules Gonin Eye 
      Hospital, University of Lausanne, 15 Avenue de France, CP 5143, CH-1004, 
      Lausanne, Switzerland. irmela.mantel@fa2.ch.
LA  - eng
PT  - Journal Article
DEP - 20220119
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Fovea Centralis/pathology
MH  - *Geographic Atrophy/diagnosis
MH  - Humans
MH  - Reproducibility of Results
MH  - Retinal Pigment Epithelium/pathology
MH  - Tomography, Optical Coherence/methods
PMC - PMC9203415
OTO - NOTNLM
OT  - Age-related macular degeneration
OT  - Algorithm
OT  - Foveal location
OT  - Geographic atrophy
OT  - Optical coherence tomography
COIS- The authors declare no competing interests.
EDAT- 2022/01/20 06:00
MHDA- 2022/06/22 06:00
PMCR- 2022/01/19
CRDT- 2022/01/19 12:28
PHST- 2021/09/06 00:00 [received]
PHST- 2021/12/07 00:00 [accepted]
PHST- 2021/11/15 00:00 [revised]
PHST- 2022/01/20 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/01/19 12:28 [entrez]
PHST- 2022/01/19 00:00 [pmc-release]
AID - 10.1007/s00417-021-05520-6 [pii]
AID - 5520 [pii]
AID - 10.1007/s00417-021-05520-6 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2022 Jul;260(7):2261-2270. doi: 
      10.1007/s00417-021-05520-6. Epub 2022 Jan 19.