PMID- 35044536
OWN - NLM
STAT- MEDLINE
DCOM- 20220725
LR  - 20220725
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
VI  - 274
DP  - 2022
TI  - From Obesity to Diabetes: The Role of the Adipose Organ.
PG  - 75-92
LID - 10.1007/164_2021_572 [doi]
AB  - Obesity is a complex, multifactorial, and relapsing disease whose prevalence has 
      tripled during the last decades and whose incidence is expected to further 
      increase. For these reasons, obesity is considered as a real pandemic, deeply 
      burdening the global health-care systems. From a pathophysiological standpoint 
      obesity is the result of a chronic-positive energy balance which in turn leads to 
      an excessive accumulation of lipids, not only within the adipose organ, but also 
      in different cytotypes, a phenomenon leading to lipotoxicity that deeply 
      compromises several cellular and organs functions. Obesity is therefore 
      associated with over 200 medical complications, including insulin resistance and 
      type 2 diabetes mellitus (T2DM) and represents the fifth leading cause of death 
      worldwide. In this review, we describe the main pathophysiological mechanisms 
      linking obesity-induced adipose organ dysfunction to insulin resistance and T2DM.
CI  - (c) 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.
FAU - Colleluori, Georgia
AU  - Colleluori G
AUID- ORCID: 0000-0002-4908-9873
AD  - Department of Experimental and Clinical Medicine, Center of Obesity, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Perugini, Jessica
AU  - Perugini J
AUID- ORCID: 0000-0002-6718-4815
AD  - Department of Experimental and Clinical Medicine, Center of Obesity, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Giordano, Antonio
AU  - Giordano A
AUID- ORCID: 0000-0003-1401-5855
AD  - Department of Experimental and Clinical Medicine, Center of Obesity, Marche 
      Polytechnic University, Ancona, Italy.
FAU - Cinti, Saverio
AU  - Cinti S
AUID- ORCID: 0000-0003-0362-5017
AD  - Department of Experimental and Clinical Medicine, Center of Obesity, Marche 
      Polytechnic University, Ancona, Italy. cinti@univpm.it.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Energy Metabolism
MH  - Humans
MH  - *Insulin Resistance/physiology
MH  - Obesity/complications
OTO - NOTNLM
OT  - Adipocytes dysfunction
OT  - Adipose tissue
OT  - Insulin resistance
OT  - Obesity
EDAT- 2022/01/20 06:00
MHDA- 2022/07/26 06:00
CRDT- 2022/01/19 12:29
PHST- 2022/01/20 06:00 [pubmed]
PHST- 2022/07/26 06:00 [medline]
PHST- 2022/01/19 12:29 [entrez]
AID - 10.1007/164_2021_572 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2022;274:75-92. doi: 10.1007/164_2021_572.