PMID- 35044560
OWN - NLM
STAT- MEDLINE
DCOM- 20220523
LR  - 20230131
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 43
IP  - 6
DP  - 2022 Jun
TI  - Does erythropoietin affect the outcome and complication rates of patient with 
      traumatic brain injury? A pooled-analysis.
PG  - 3783-3793
LID - 10.1007/s10072-022-05877-4 [doi]
AB  - OBJECTIVE: The aim of this meta-analysis was to review the scientific literature 
      published until April 18, 2021, to summarize existing knowledge on the efficacy 
      and safety of erythropoietin (EPO) for traumatic brain injury (TBI). METHODS: 
      This systematic review followed PRISMA guidelines. Randomized controlled trials 
      (RCTs) reporting on the efficacy and safety of EPO in the treatment of TBI were 
      systematically searched in relevant electronic databases according to a 
      pre-designed search strategy. The primary outcomes are the mortality; and 
      secondary outcomes are the good functional outcome (GFO) and adverse events 
      (AEs). RESULTS: A total of 10 RCTs involving 2,402 participants fulfilled the 
      inclusion criteria. The results showed that there is a significant difference in 
      terms of the mortality (RR = 0.67, 95% CI = 0.54-0.84, P = 0.0003) and seizure 
      rate (RR = 0.52, 95% CI = 0.29-0.96, P = 0.04) between the EPO groups compared to 
      those in the control groups. However, compared with the control groups, the GFO 
      in the EPO groups was not statistically significant (RR = 1.18, 95% 
      CI = 0.93-1.48, P = 0.17). CONCLUSIONS: Findings of the present meta-analysis 
      suggest that the use of EPO could reduce mortality rate in patients with TBI, 
      without increasing the incidence of AEs. EPO has potential research and 
      application value in the treatment of TBI.
CI  - (c) 2022. Fondazione Societa Italiana di Neurologia.
FAU - Li, Yuping
AU  - Li Y
AD  - Neuro Intensive Care Unit, Department of Neurosurgery, Clinical Medical College, 
      Yangzhou University, Yangzhou, China.
AD  - Department of Neurosurgery, Yangzhou Clinical Medical College of Xuzhou Medical 
      University, Xuzhou, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Wang, Haili
AU  - Wang H
AD  - Department of Clinical Medicine, Dalian Medical University, Dalian Liaoning, 
      China.
FAU - Zhu, Lei
AU  - Zhu L
AD  - Neuro Intensive Care Unit, Department of Neurosurgery, Clinical Medical College, 
      Yangzhou University, Yangzhou, China.
FAU - Zhang, Hengzhu
AU  - Zhang H
AD  - Department of Neurosurgery, Yangzhou Clinical Medical College of Xuzhou Medical 
      University, Xuzhou, China.
FAU - Ma, Qiang
AU  - Ma Q
AD  - Neuro Intensive Care Unit, Department of Neurosurgery, Clinical Medical College, 
      Yangzhou University, Yangzhou, China.
FAU - Liu, Xiaoguang
AU  - Liu X
AD  - Neuro Intensive Care Unit, Department of Neurosurgery, Clinical Medical College, 
      Yangzhou University, Yangzhou, China.
FAU - Dong, Lun
AU  - Dong L
AD  - Neuro Intensive Care Unit, Department of Neurosurgery, Clinical Medical College, 
      Yangzhou University, Yangzhou, China.
AD  - Department of Neurosurgery, Yangzhou Clinical Medical College of Xuzhou Medical 
      University, Xuzhou, China.
FAU - Lu, Guangyu
AU  - Lu G
AUID- ORCID: 0000-0003-2568-7091
AD  - Institute of Public Health, Medical College, Yangzhou University, Yangzhou, 
      China. Guangyu.lu@yzu.edu.cn.
LA  - eng
GR  - BK20190241/Basic Research Program of Jiangsu Province/
GR  - QNRC2016326/Jiangsu Provincial Key Medical Talents Program/
GR  - 201902/Jiangsu Province Key Experiments of Basic and Clinical Translation of 
      Non-coding RNA/
GR  - 82172603/China Natural Science Foundation/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20220119
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
CIN - Neurol Sci. 2023 Jan;44(1):355-356. PMID: 36030463
MH  - *Brain Injuries, Traumatic/complications/drug therapy
MH  - *Erythropoietin/adverse effects
MH  - Humans
MH  - Incidence
MH  - Seizures/drug therapy
OTO - NOTNLM
OT  - Erythropoietin
OT  - Good functional outcome
OT  - Meta-analysis
OT  - Mortality
OT  - Traumatic brain injury
EDAT- 2022/01/20 06:00
MHDA- 2022/05/24 06:00
CRDT- 2022/01/19 12:30
PHST- 2021/05/31 00:00 [received]
PHST- 2022/01/08 00:00 [accepted]
PHST- 2022/01/20 06:00 [pubmed]
PHST- 2022/05/24 06:00 [medline]
PHST- 2022/01/19 12:30 [entrez]
AID - 10.1007/s10072-022-05877-4 [pii]
AID - 10.1007/s10072-022-05877-4 [doi]
PST - ppublish
SO  - Neurol Sci. 2022 Jun;43(6):3783-3793. doi: 10.1007/s10072-022-05877-4. Epub 2022 
      Jan 19.