PMID- 35046547 OWN - NLM STAT- MEDLINE DCOM- 20230111 LR - 20240102 IS - 1476-5454 (Electronic) IS - 0950-222X (Print) IS - 0950-222X (Linking) VI - 37 IP - 1 DP - 2023 Jan TI - Thickness of retinal pigment epithelium-Bruch's membrane complex in adult Chinese using optical coherence tomography. PG - 155-159 LID - 10.1038/s41433-021-01911-5 [doi] AB - PURPOSE: To study thickness of RPE-BM complex in adult Chinese subjects and its correlation with systemic and ocular biometric parameters. DESIGN: Population-based longitudinal study. Cross-sectional study. PARTICIPANTS: The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 +/- 9.8 years (range: 50-93 years). METHODS: A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (SD OCT) for measurement of the thickness of RPE-BM complex. Use Heidelberg software "Heidelberg Eye Explorer" for segmentation and measurements. MAIN OUTCOME MEASURE: Thickness of RPE-BM complex. RESULTS: In total, 3276 people (6530 eyes) were included in the study. In total, 1844 (56.3%) subjects were female. The mean age was 64.3 +/- 9.6 years (range: 50-93 years). The mean refractive error (spherical equivalent) was -0.18 +/- 2.04 diopters (range: -22.0 to +7.50 diopters). Mean thickness of the RPE-BM complex at the foveal center was 25.09 +/- 3.98 mum (range: 17-37 mum). In multiple regression analysis, subfoveal thickness of the RPE-BM complex was associated with age (p = 0.039; beta: 0.22; B: 0.10 (95% CI: 0.01, 0.20)) and hypertension history (p = 0.038; beta: 0.23; B: 1.96 (95% CI: 0.12, 3.81)). CONCLUSION: Mean subfoveal thickness of the RPE-BM complex was 25.09 +/- 3.98 mum in elderly subjects with a mean age of 64.3 years increased with age and hypertension history. The increase in the thickness of RPE-BM complex may play a role in the pathophysiologic features of various age-related ocular conditions. CI - (c) 2021. The Author(s), under exclusive licence to The Royal College of Ophthalmologists. FAU - Shao, Lei AU - Shao L AD - Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Zhang, Qing Lin AU - Zhang QL AD - Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, China. FAU - Zhang, Chuan AU - Zhang C AD - Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Dong, Li AU - Dong L AUID- ORCID: 0000-0003-0120-5756 AD - Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Zhou, Wen Da AU - Zhou WD AD - Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Zhang, Rui Heng AU - Zhang RH AD - Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Wu, Hao Tian AU - Wu HT AD - Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Wei, Wen Bin AU - Wei WB AUID- ORCID: 0000-0003-2386-0989 AD - Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. weiwenbintr@163.com. LA - eng PT - Comment PT - Journal Article DEP - 20220120 PL - England TA - Eye (Lond) JT - Eye (London, England) JID - 8703986 SB - IM CON - Ophthalmology. 2014 Aug;121(8):1572-8. PMID: 24755005 MH - Humans MH - Adult MH - Female MH - Aged MH - Middle Aged MH - Male MH - *Retinal Pigment Epithelium/diagnostic imaging MH - *Bruch Membrane MH - Tomography, Optical Coherence/methods MH - Cross-Sectional Studies MH - East Asian People MH - Longitudinal Studies PMC - PMC9829656 COIS- The authors declare no competing interests. EDAT- 2022/01/21 06:00 MHDA- 2023/01/12 06:00 PMCR- 2024/01/01 CRDT- 2022/01/20 05:56 PHST- 2021/09/22 00:00 [received] PHST- 2021/12/15 00:00 [accepted] PHST- 2021/12/05 00:00 [revised] PHST- 2022/01/21 06:00 [pubmed] PHST- 2023/01/12 06:00 [medline] PHST- 2022/01/20 05:56 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.1038/s41433-021-01911-5 [pii] AID - 1911 [pii] AID - 10.1038/s41433-021-01911-5 [doi] PST - ppublish SO - Eye (Lond). 2023 Jan;37(1):155-159. doi: 10.1038/s41433-021-01911-5. Epub 2022 Jan 20.