PMID- 35046689
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231105
IS  - 1178-7015 (Print)
IS  - 1178-7015 (Electronic)
IS  - 1178-7015 (Linking)
VI  - 15
DP  - 2022
TI  - Subacute Cutaneous Lupus Erythematosus-Like Eruption Induced by Durvalumab: A 
      Case Report and Literature Review.
PG  - 51-62
LID - 10.2147/CCID.S344445 [doi]
AB  - Reports of immune-related adverse events caused by programmed cell death-ligand 1 
      (PD-L1) inhibitor have been emerging. Herein, we report a subacute cutaneous 
      lupus erythematosus (SCLE)-like eruption presented after the treatment of 
      durvalumab in a patient with extensive-stage small cell lung carcinoma. A 
      74-year-old Thai man was referred to our department after experiencing multiple 
      dusky red to brownish papules and patches with scale and erosions on 
      photo-distributed areas after receiving 3 infusion cycles of durvalumab. 
      Histological finding revealed epidermal atrophy with interface changes and 
      superficial perivascular infiltration of lymphocytes. Serum antinuclear 
      antibodies (ANA) was 1:320 and anti-Ro/Sjogren's-syndrome-related antigen A 
      (anti-Ro/SSA) antibodies were positive (2+). Based on the history and 
      clinicopathological correlation, the diagnosis of SCLE-like eruption due to 
      durvalumab was made. To the best of our knowledge, this is the first case of 
      durvalumab-induced SCLE.
CI  - (c) 2022 Pratumchart et al.
FAU - Pratumchart, Nathathai
AU  - Pratumchart N
AD  - Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Chanprapaph, Kumutnart
AU  - Chanprapaph K
AUID- ORCID: 0000-0001-7931-3816
AD  - Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Topibulpong, Nuttapong
AU  - Topibulpong N
AD  - Division of Oncology, Department of Internal Medicine, Faculty of Medicine, 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
FAU - Tankunakorn, Jutamas
AU  - Tankunakorn J
AUID- ORCID: 0000-0001-9797-7499
AD  - Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, 
      Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
LA  - eng
PT  - Case Reports
DEP - 20220113
PL  - New Zealand
TA  - Clin Cosmet Investig Dermatol
JT  - Clinical, cosmetic and investigational dermatology
JID - 101543449
PMC - PMC8763206
OTO - NOTNLM
OT  - durvalumab
OT  - immune-related adverse events
OT  - programmed cell death-ligand 1 inhibitor
OT  - subacute cutaneous lupus erythematosus
COIS- The authors report no conflicts of interest in this work.
EDAT- 2022/01/21 06:00
MHDA- 2022/01/21 06:01
PMCR- 2022/01/13
CRDT- 2022/01/20 05:59
PHST- 2021/10/14 00:00 [received]
PHST- 2021/12/21 00:00 [accepted]
PHST- 2022/01/20 05:59 [entrez]
PHST- 2022/01/21 06:00 [pubmed]
PHST- 2022/01/21 06:01 [medline]
PHST- 2022/01/13 00:00 [pmc-release]
AID - 344445 [pii]
AID - 10.2147/CCID.S344445 [doi]
PST - epublish
SO  - Clin Cosmet Investig Dermatol. 2022 Jan 13;15:51-62. doi: 10.2147/CCID.S344445. 
      eCollection 2022.