PMID- 35047824
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220201
IS  - 2632-8674 (Electronic)
IS  - 2632-8674 (Linking)
VI  - 4
IP  - 1
DP  - 2022 Mar
TI  - High-grade ovarian cancer associated H/ACA snoRNAs promote cancer cell 
      proliferation and survival.
PG  - zcab050
LID - 10.1093/narcan/zcab050 [doi]
LID - zcab050
AB  - Small nucleolar RNAs (snoRNAs) are an omnipresent class of non-coding RNAs 
      involved in the modification and processing of ribosomal RNA (rRNA). As snoRNAs 
      are required for ribosome production, the increase of which is a hallmark of 
      cancer development, their expression would be expected to increase in 
      proliferating cancer cells. However, assessing the nature and extent of snoRNAs' 
      contribution to cancer biology has been largely limited by difficulties in 
      detecting highly structured RNA. In this study, we used a dedicated midsize 
      non-coding RNA (mncRNA) sensitive sequencing technique to accurately survey the 
      snoRNA abundance in independently verified high-grade serous ovarian carcinoma 
      (HGSC) and serous borderline tumour (SBT) tissues. The results identified 
      SNORA81, SNORA19 and SNORA56 as an H/ACA snoRNA signature capable of 
      discriminating between independent sets of HGSC, SBT and normal tissues. The 
      expression of the signature SNORA81 correlates with the level of ribosomal RNA 
      (rRNA) modification and its knockdown inhibits 28S rRNA pseudouridylation and 
      accumulation leading to reduced cell proliferation and migration. Together our 
      data indicate that specific subsets of H/ACA snoRNAs may promote tumour 
      aggressiveness by inducing rRNA modification and synthesis.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic 
      Acids Research.
FAU - Faucher-Giguere, Laurence
AU  - Faucher-Giguere L
AUID- ORCID: 0000-0002-5726-6446
FAU - Roy, Audrey
AU  - Roy A
FAU - Deschamps-Francoeur, Gabrielle
AU  - Deschamps-Francoeur G
AUID- ORCID: 0000-0001-7129-960X
FAU - Couture, Sonia
AU  - Couture S
FAU - Nottingham, Ryan M
AU  - Nottingham RM
FAU - Lambowitz, Alan M
AU  - Lambowitz AM
FAU - Scott, Michelle S
AU  - Scott MS
AUID- ORCID: 0000-0001-6231-7714
FAU - Abou Elela, Sherif
AU  - Abou Elela S
AUID- ORCID: 0000-0002-0630-3294
LA  - eng
GR  - R35 GM136216/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20220114
PL  - England
TA  - NAR Cancer
JT  - NAR cancer
JID - 101769553
PMC - PMC8759569
EDAT- 2022/01/21 06:00
MHDA- 2022/01/21 06:01
PMCR- 2022/01/14
CRDT- 2022/01/20 06:09
PHST- 2021/08/23 00:00 [received]
PHST- 2021/12/08 00:00 [revised]
PHST- 2021/12/13 00:00 [accepted]
PHST- 2022/01/20 06:09 [entrez]
PHST- 2022/01/21 06:00 [pubmed]
PHST- 2022/01/21 06:01 [medline]
PHST- 2022/01/14 00:00 [pmc-release]
AID - zcab050 [pii]
AID - 10.1093/narcan/zcab050 [doi]
PST - epublish
SO  - NAR Cancer. 2022 Jan 14;4(1):zcab050. doi: 10.1093/narcan/zcab050. eCollection 
      2022 Mar.