PMID- 35048560
OWN - NLM
STAT- MEDLINE
DCOM- 20220418
LR  - 20220418
IS  - 2366-9608 (Electronic)
IS  - 2366-9608 (Linking)
VI  - 6
IP  - 3
DP  - 2022 Mar
TI  - The Intracellular and Extracellular Microenvironment of Tumor Site: The Trigger 
      of Stimuli-Responsive Drug Delivery Systems.
PG  - e2101437
LID - 10.1002/smtd.202101437 [doi]
AB  - The tumor microenvironment (TME), including intracellular and extracellular 
      microenvironment, contains many biochemical indicators (such as 
      acidity/alkalinity, oxygen content, and enzymatic activity) that are different 
      from the normal physiological environment. These abnormal biochemical indicators 
      can accelerate the heterogeneity of tumors, but on the other hand, they also 
      provide opportunities for the design of intelligent drug delivery systems (DDSs). 
      The TME-responsive DDSs have shown great potential in reducing the side effects 
      of chemotherapy and improving the curative effect of tumors. In this review, the 
      abnormal biochemical indicators of TME are introduced in detail from both the 
      extracellular and intracellular aspects. In view of the various physiological 
      barriers encountered during drug delivery, the strategy of constructing 
      TME-responsive DDSs is discussed. By summarizing the typical research progress, 
      the authors prospect the development of TME-responsive DDS in the future.
CI  - (c) 2022 Wiley-VCH GmbH.
FAU - Jing, Xiaodong
AU  - Jing X
AD  - Institute of Biomedical Materials and Engineering, College of Materials Science 
      and Engineering, College of Chemistry and Chemical Engineering, Qingdao 
      University, Qingdao, 266071, China.
FAU - Hu, Hao
AU  - Hu H
AD  - Institute of Biomedical Materials and Engineering, College of Materials Science 
      and Engineering, College of Chemistry and Chemical Engineering, Qingdao 
      University, Qingdao, 266071, China.
FAU - Sun, Yanzhen
AU  - Sun Y
AD  - Institute of Biomedical Materials and Engineering, College of Materials Science 
      and Engineering, College of Chemistry and Chemical Engineering, Qingdao 
      University, Qingdao, 266071, China.
FAU - Yu, Bing
AU  - Yu B
AD  - Institute of Biomedical Materials and Engineering, College of Materials Science 
      and Engineering, College of Chemistry and Chemical Engineering, Qingdao 
      University, Qingdao, 266071, China.
AD  - State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, 
      266071, China.
FAU - Cong, Hailin
AU  - Cong H
AUID- ORCID: 0000-0001-9044-1376
AD  - Institute of Biomedical Materials and Engineering, College of Materials Science 
      and Engineering, College of Chemistry and Chemical Engineering, Qingdao 
      University, Qingdao, 266071, China.
AD  - State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, 
      266071, China.
FAU - Shen, Youqing
AU  - Shen Y
AD  - Institute of Biomedical Materials and Engineering, College of Materials Science 
      and Engineering, College of Chemistry and Chemical Engineering, Qingdao 
      University, Qingdao, 266071, China.
AD  - Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center 
      for Bionanoengineering, and Department of Chemical and Biological Engineering, 
      Zhejiang University, Hangzhou, Zhejiang, 310027, China.
LA  - eng
GR  - 21675091/National Natural Science Foundation of China/
GR  - 21874078/National Natural Science Foundation of China/
GR  - 22074072/National Natural Science Foundation of China/
GR  - 51703105/National Natural Science Foundation of China/
GR  - tsqn20161027/Taishan Young Scholar Program of Shandong Province/
GR  - 2018CXGC1407/Major Science and Technology Innovation Project of Shandong 
      Province/
GR  - 2016GGX102028/Key Research and Development Project of Shandong Province/
GR  - 2016GGX102039/Key Research and Development Project of Shandong Province/
GR  - 2017GGX20111/Key Research and Development Project of Shandong Province/
GR  - 2018M630752/China Postdoctoral Science Foundation/
GR  - First Class Discipline Project of Shandong Province/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220120
PL  - Germany
TA  - Small Methods
JT  - Small methods
JID - 101724536
SB  - IM
MH  - *Drug Delivery Systems
MH  - Humans
MH  - *Neoplasms/drug therapy
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - drug delivery systems
OT  - nano carriers
OT  - stimuli-responsiveness
OT  - tumor microenvironment
OT  - tumor treatments
EDAT- 2022/01/21 06:00
MHDA- 2022/04/19 06:00
CRDT- 2022/01/20 06:40
PHST- 2021/12/29 00:00 [revised]
PHST- 2021/11/19 00:00 [received]
PHST- 2022/01/21 06:00 [pubmed]
PHST- 2022/04/19 06:00 [medline]
PHST- 2022/01/20 06:40 [entrez]
AID - 10.1002/smtd.202101437 [doi]
PST - ppublish
SO  - Small Methods. 2022 Mar;6(3):e2101437. doi: 10.1002/smtd.202101437. Epub 2022 Jan 
      20.