PMID- 35048791
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20230124
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 23
IP  - 8
DP  - 2022 Oct
TI  - Relationships between global functioning and neuropsychological predictors in 
      subjects at high risk of psychosis or with a recent onset of depression.
PG  - 573-581
LID - 10.1080/15622975.2021.2014955 [doi]
AB  - OBJECTIVE: Psychotic disorders are frequently associated with decline in 
      functioning and cognitive difficulties are observed in subjects at clinical high 
      risk (CHR) for psychosis. In this work, we applied automatic approaches to 
      neurocognitive and functioning measures, with the aim of investigating the link 
      between global, social and occupational functioning, and cognition. METHODS: 102 
      CHR subjects and 110 patients with recent onset depression (ROD) were recruited. 
      Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability 
      (GAF-D). and global functioning social (GF-S) and role (GF-R), at baseline and of 
      the previous month and year, and a set of neurocognitive measures, were used for 
      classification and regression. RESULTS: Neurocognitive measures related to GF-R 
      at baseline (r = 0.20, p = 0.004), GF-S at present (r = 0.14, p = 0.042) and of 
      the past year (r = 0.19, p = 0.005), for GAF-F of the past month (r = 0.24, 
      p < 0.001) and GAF-D of the past year (r = 0.28, p = 0.002). Classification 
      reached values of balanced accuracy of 61% for GF-R and GAF-D. CONCLUSION: We 
      found that neurocognition was related to psychosocial functioning. More 
      specifically, a deficit in executive functions was associated to poor social and 
      occupational functioning.
FAU - Squarcina, Letizia
AU  - Squarcina L
AD  - Department of Pathophysiology and Transplantation, University of Milan, Milan, 
      Italy.
FAU - Kambeitz-Ilankovic, Lana
AU  - Kambeitz-Ilankovic L
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany.
AD  - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University 
      Hospital, University of Cologne, Cologne, Germany.
FAU - Bonivento, Carolina
AU  - Bonivento C
AD  - IRCCS E. Medea, San Vito al Tagliamento, Italy.
FAU - Prunas, Cecilia
AU  - Prunas C
AD  - Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Oldani, Lucio
AU  - Oldani L
AD  - Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Wenzel, Julian
AU  - Wenzel J
AD  - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University 
      Hospital, University of Cologne, Cologne, Germany.
FAU - Ruef, Anne
AU  - Ruef A
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany.
FAU - Dwyer, Dominic
AU  - Dwyer D
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany.
FAU - Ferro, Adele
AU  - Ferro A
AD  - Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Borgwardt, Stefan
AU  - Borgwardt S
AD  - Department of Psychiatry, (Psychiatric University Hospital, UPK), University of 
      Basel, Basel, Switzerland.
AD  - Department of Psychiatry and Psychotherapy, University of Lubeck, Lubeck, 
      Germany.
FAU - Kambeitz, Joseph
AU  - Kambeitz J
AD  - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University 
      Hospital, University of Cologne, Cologne, Germany.
FAU - Lichtenstein, Theresa Katharina
AU  - Lichtenstein TK
AD  - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University 
      Hospital, University of Cologne, Cologne, Germany.
FAU - Meisenzahl, Eva
AU  - Meisenzahl E
AD  - Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine 
      University, Dusseldorf, Germany.
FAU - Pantelis, Christos
AU  - Pantelis C
AD  - Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, 
      Melbourne, Australia.
FAU - Rosen, Marlene
AU  - Rosen M
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany.
FAU - Upthegrove, Rachel
AU  - Upthegrove R
AUID- ORCID: 0000-0001-8204-5103
AD  - Institute for Mental Health and Centre for Human Brain Health, University of 
      Birmingham, Birmingham, UK.
FAU - Antonucci, Linda A
AU  - Antonucci LA
AD  - Department of Education, Psychology and Communication, University of Bari "Aldo 
      Moro" - Bari, Italy.
FAU - Bertolino, Alessandro
AU  - Bertolino A
AD  - Department of Basic Medical Science, Neuroscience and Sense Organs, University of 
      Bari "Aldo Moro", Bari, Italy.
FAU - Lencer, Rebekka
AU  - Lencer R
AUID- ORCID: 0000-0003-4032-7297
AD  - Department of Psychiatry and Psychotherapy, University of Lubeck, Lubeck, 
      Germany.
AD  - Institute for Translational Psychiatry, Westfalische-Wilhelms-University Munster, 
      Munster, Germany.
FAU - Ruhrmann, Stephan
AU  - Ruhrmann S
AD  - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University 
      Hospital, University of Cologne, Cologne, Germany.
FAU - Salokangas, Raimo R K
AU  - Salokangas RRK
AD  - Department of Psychiatry, University of Turku, Turku, Finland.
FAU - Schultze-Lutter, Frauke
AU  - Schultze-Lutter F
AD  - Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine 
      University, Dusseldorf, Germany.
AD  - Department of Psychology, Faculty of Psychology, Airlangga University, Surabaya, 
      Indonesia.
FAU - Chisholm, Katharine
AU  - Chisholm K
AD  - Institute for Mental Health and Centre for Human Brain Health, University of 
      Birmingham, Birmingham, UK.
FAU - Stainton, Alexandra
AU  - Stainton A
AD  - Centre for Youth Mental Health, University of Melbourne, Parkville, Australia.
FAU - Wood, Stephen J
AU  - Wood SJ
AD  - Centre for Youth Mental Health, University of Melbourne, Parkville, Australia.
AD  - Orygen, Melbourne, Australia.
AD  - Institute for Mental Health, University of Birmingham, Birmingham, UK.
FAU - Koutsouleris, Nikolaos
AU  - Koutsouleris N
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, 
      Germany.
FAU - Brambilla, Paolo
AU  - Brambilla P
AD  - Department of Pathophysiology and Transplantation, University of Milan, Milan, 
      Italy.
AD  - Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
CN  - PRONIA consortium
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220120
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
SB  - IM
MH  - Humans
MH  - Psychiatric Status Rating Scales
MH  - Depression
MH  - Neuropsychological Tests
MH  - *Psychotic Disorders/diagnosis
MH  - *Cognition Disorders/psychology
OTO - NOTNLM
OT  - Cognition
OT  - classification
OT  - machine learning
OT  - neuropsychology
EDAT- 2022/01/21 06:00
MHDA- 2022/11/30 06:00
CRDT- 2022/01/20 08:48
PHST- 2022/01/21 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/01/20 08:48 [entrez]
AID - 10.1080/15622975.2021.2014955 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2022 Oct;23(8):573-581. doi: 
      10.1080/15622975.2021.2014955. Epub 2022 Jan 20.