PMID- 35049210
OWN - NLM
STAT- MEDLINE
DCOM- 20220207
LR  - 20220716
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 48
DP  - 2021 Dec 3
TI  - Efficacy of complementary medicine for nonsteroidal anti-inflammatory 
      drug-induced small intestinal injuries: A narrative review.
PG  - e28005
LID - 10.1097/MD.0000000000028005 [doi]
LID - e28005
AB  - Nonsteroidal anti-inflammatory drug-induced small bowel injuries (NSIs) have been 
      largely ignored for decades due to the focus on nonsteroidal anti-inflammatory 
      drug gastropathy. With the visualization of the small intestines enabled by video 
      capsule endoscopy, the frequency and severity of NSIs have become more evident. 
      NSIs have a complex pathophysiology, and no effective preventive or treatment 
      options have been proven. Complementary and alternative medicine (CAM) has been 
      used to treat disorders of the small intestine, and more research on its 
      effectiveness for NSIs has been conducted.We reviewed the current evidence and 
      mechanisms of action of CAMs on NSI. Clinical and experimental studies on the 
      effect of CAMs on NSIs were performed using 10 databases.Twenty-two studies (3 
      clinical and 19 in vivo experimental studies) were included in the final analysis 
      involving 10 kinds of CAMs: bovine colostrum, Orengedokuto (coptis), muscovite, 
      licorice, grape seed, wheat, brown seaweed, Ganoderma lucidum fungus mycelia, 
      Chaenomeles speciosa (sweet) Nakai (muguasantie), and Jinghua Weikang capsule. 
      The mechanisms of CAM include an increase in prostaglandin E2, reparation of the 
      enteric nervous system, inhibition of pro-inflammatory cytokines, reduction of 
      intestinal permeability and enteric bacterial numbers, decrease in oxidative 
      stress, and modulation of small intestinal motility.CAM may be a novel 
      alternative option for treating and preventing NSI, and further studies on human 
      and animal models with relevant comorbidities are warranted.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Cho, Minji
AU  - Cho M
AD  - Department of Gastroenterology, College of Korean Medicine, Kyung Hee University, 
      Seoul, Republic of Korea.
FAU - Bu, Youngmin
AU  - Bu Y
AD  - Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee 
      University, Seoul, Republic of Korea.
FAU - Park, Jae-Woo
AU  - Park JW
AD  - Department of Gastroenterology, College of Korean Medicine, Kyung Hee University, 
      Seoul, Republic of Korea.
FAU - Rahman, Hasanur
AU  - Rahman H
AD  - Department of Biotechnology and Genetic Engineering, Faculty of Life Sciences, 
      Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 
      Bangladesh.
FAU - Ko, Seok-Jae
AU  - Ko SJ
AUID- ORCID: 0000-0002-9902-0938
AD  - Department of Gastroenterology, College of Korean Medicine, Kyung Hee University, 
      Seoul, Republic of Korea.
LA  - eng
GR  - No. 2019R1F1A1059547/the national research foundation of korea (nrf) grant funded 
      by the korea government (msit)/
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
MH  - Cattle
MH  - Complementary Therapies/*methods
MH  - Humans
MH  - Intestine, Small/*drug effects/*injuries
MH  - Intestines
PMC - PMC9191556
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2022/01/21 06:00
MHDA- 2022/02/08 06:00
PMCR- 2021/12/03
CRDT- 2022/01/20 09:43
PHST- 2021/07/15 00:00 [received]
PHST- 2021/11/11 00:00 [accepted]
PHST- 2022/01/20 09:43 [entrez]
PHST- 2022/01/21 06:00 [pubmed]
PHST- 2022/02/08 06:00 [medline]
PHST- 2021/12/03 00:00 [pmc-release]
AID - 00005792-202112030-00046 [pii]
AID - MD-D-21-05016 [pii]
AID - 10.1097/MD.0000000000028005 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Dec 3;100(48):e28005. doi: 
      10.1097/MD.0000000000028005.