PMID- 35049409 OWN - NLM STAT- MEDLINE DCOM- 20220310 LR - 20220310 IS - 1477-0962 (Electronic) IS - 0961-2033 (Linking) VI - 31 IP - 2 DP - 2022 Feb TI - IgA anti-dsDNA antibodies: A neglected serological parameter in systemic lupus erythematosus. PG - 137-142 LID - 10.1177/09612033221074184 [doi] AB - Anti-double-stranded DNA (anti-dsDNA) autoantibodies are archetypal biomarkers found in systemic lupus erythematosus (SLE). Although they can exist in any isotype, very little is understood about the IgA isotype for which most of our knowledge is derived from observational studies. This review article summarises our knowledge of this autoantibody isotype to date. Attention will be spent on clinical associations as well as its potential links with lupus nephritis for which there is still some controversy. Further understanding of this serological parameter may facilitate diagnosis, prognosis and treatments of systemic lupus erythematosus patients. FAU - Lee, Adrian Y S AU - Lee AYS AUID- ORCID: 0000-0002-5179-4803 AD - 8539Westmead Hospital, Westmead, NSW, Australia. AD - ICPMR, NSW Health Pathology, Westmead, NSW, Australia. AD - Westmead Clinical School, University of Sydney, Westmead, NSW, Australia. LA - eng PT - Journal Article PT - Review DEP - 20220120 PL - England TA - Lupus JT - Lupus JID - 9204265 RN - 0 (Antibodies, Antinuclear) RN - 0 (Autoantibodies) RN - 0 (Immunoglobulin A) RN - 0 (Immunoglobulin Isotypes) RN - 0 (anti-dsDNA autoantibody) SB - IM MH - Antibodies, Antinuclear/blood MH - Autoantibodies MH - Humans MH - Immunoglobulin A/blood MH - Immunoglobulin Isotypes MH - *Lupus Erythematosus, Systemic/diagnosis MH - *Lupus Nephritis/diagnosis OTO - NOTNLM OT - IgA OT - anti-dsDNA OT - antinuclear antibodies OT - autoantibodies OT - systemic lupus erythematosus EDAT- 2022/01/21 06:00 MHDA- 2022/03/11 06:00 CRDT- 2022/01/20 12:20 PHST- 2022/01/21 06:00 [pubmed] PHST- 2022/03/11 06:00 [medline] PHST- 2022/01/20 12:20 [entrez] AID - 10.1177/09612033221074184 [doi] PST - ppublish SO - Lupus. 2022 Feb;31(2):137-142. doi: 10.1177/09612033221074184. Epub 2022 Jan 20.