PMID- 35050344
OWN - NLM
STAT- MEDLINE
DCOM- 20220126
LR  - 20220127
IS  - 2164-2591 (Electronic)
IS  - 2164-2591 (Linking)
VI  - 11
IP  - 1
DP  - 2022 Jan 3
TI  - Noninvasive Estimation of Pulsatile and Static Intracranial Pressure by Optical 
      Coherence Tomography.
PG  - 31
LID - 10.1167/tvst.11.1.31 [doi]
LID - 31
AB  - PURPOSE: To explore the ability of optical coherence tomography (OCT) to 
      noninvasively estimate pulsatile and static intracranial pressure (ICP). METHODS: 
      An OCT examination was performed in patients who underwent continuous overnight 
      monitoring of the pulsatile and static ICP for diagnostic purpose. We included 
      two patient groups, patients with idiopathic intracranial hypertension (IIH; n = 
      20) and patients with no verified cerebrospinal fluid disturbances (reference; n 
      = 12). Several OCT parameters were acquired using spectral-domain OCT (RS-3000 
      Advance; NIDEK, Singapore). The ICP measurements were obtained using a 
      parenchymal sensor (Codman ICP MicroSensor; Johnson & Johnson, Raynham, MA, USA). 
      The pulsatile ICP was determined as the mean ICP wave amplitude (MWA), and the 
      static ICP was determined as the mean ICP. RESULTS: The peripapillary Bruch's 
      membrane angle (pBA) and the optic nerve head height (ONHH) differed between the 
      IIH and reference groups and correlated with both MWA and mean ICP. Both OCT 
      parameters predicted elevated MWA. Area under the curve and cutoffs were 0.82 
      (95% confidence interval [CI], 0.66-0.98) and -0.65 degrees  (sensitivity/specificity; 
      0.75/0.92) for pBA and 0.84 (95% CI, 0.70-0.99) and 405 microm (0.88/0.67) for ONHH. 
      Adjusting for age and body mass index resulted in nonsignificant predictive 
      values for mean ICP, whereas the predictive value for MWA remained significant. 
      CONCLUSIONS: This study provides evidence that the OCT parameters pBA and ONHH 
      noninvasively can predict elevated pulsatile ICP, represented by the MWA. 
      TRANSLATIONAL RELEVANCE: OCT shows promise as a method for noninvasive estimation 
      of ICP.
FAU - Jacobsen, Henrik Holvin
AU  - Jacobsen HH
AD  - Department of Ophthalmology, Oslo University Hospital-Ulleval, Oslo, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Jorstad, Oystein Kalsnes
AU  - Jorstad OK
AD  - Department of Ophthalmology, Oslo University Hospital-Ulleval, Oslo, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Moe, Morten C
AU  - Moe MC
AD  - Department of Ophthalmology, Oslo University Hospital-Ulleval, Oslo, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Petrovski, Goran
AU  - Petrovski G
AD  - Department of Ophthalmology, Oslo University Hospital-Ulleval, Oslo, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
AD  - Department of Ophthalmology, University of Split School of Medicine, Split, 
      Croatia.
FAU - Pripp, Are Hugo
AU  - Pripp AH
AD  - Oslo Centre of Biostatistics and Epidemiology, Research Support Services, Oslo 
      University Hospital, Oslo, Norway.
FAU - Sandell, Tiril
AU  - Sandell T
AD  - Department of Ophthalmology, Oslo University Hospital-Ulleval, Oslo, Norway.
AD  - Department of Ophthalmology, Vestre Viken Hospital, Drammen, Norway.
FAU - Eide, Per Kristian
AU  - Eide PK
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
AD  - Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, Oslo, 
      Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transl Vis Sci Technol
JT  - Translational vision science & technology
JID - 101595919
SB  - IM
MH  - Humans
MH  - *Intracranial Hypertension/diagnostic imaging
MH  - Intracranial Pressure
MH  - *Optic Disk
MH  - *Pseudotumor Cerebri
MH  - Tomography, Optical Coherence
PMC - PMC8787623
COIS- Disclosure: H.H. Jacobsen, None; O.K. Jorstad, None; M.C. Moe, None; G. 
      Petrovski, None; A.H. Pripp, None; T. Sandell, None; P.K. Eide, None
EDAT- 2022/01/21 06:00
MHDA- 2022/01/27 06:00
PMCR- 2022/01/20
CRDT- 2022/01/20 12:34
PHST- 2022/01/20 12:34 [entrez]
PHST- 2022/01/21 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2022/01/20 00:00 [pmc-release]
AID - 2778293 [pii]
AID - TVST-21-4002 [pii]
AID - 10.1167/tvst.11.1.31 [doi]
PST - ppublish
SO  - Transl Vis Sci Technol. 2022 Jan 3;11(1):31. doi: 10.1167/tvst.11.1.31.