PMID- 35050990
OWN - NLM
STAT- MEDLINE
DCOM- 20220301
LR  - 20220301
IS  - 2072-6651 (Electronic)
IS  - 2072-6651 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Dec 23
TI  - Predictors of Clinically Important Improvements in Motor Function and Daily Use 
      of Affected Arm after a Botulinum Toxin A Injection in Patients with Chronic 
      Stroke.
LID - 10.3390/toxins14010013 [doi]
LID - 13
AB  - Identifying patients who can gain minimal clinically important difference (MCID) 
      in active motor function in the affected upper extremity (UE) after a botulinum 
      toxin A (BoNT-A) injection for post-stroke spasticity is important. Eighty-eight 
      participants received a BoNT-A injection in the affected UE. Two outcome 
      measures, Fugl-Meyer Assessment Upper Extremity (FMA-UE) and Motor Activity Log 
      (MAL), were assessed at pre-injection and after 24 rehabilitation sessions. We 
      defined favorable response as an FMA-UE change score >/=5 or MAL change score 
      >/=0.5.Statistical analysis revealed that the time since stroke less than 36 months 
      (odds ratio (OR) = 4.902 (1.219-13.732); p = 0.023) was a significant predictor 
      of gaining MCID in the FMA-UE. Medical Research Council scale -proximal UE (OR = 
      1.930 (1.004-3.710); p = 0.049) and post-injection duration (OR = 1.039 
      (1.006-1.074); p =0.021) were two significant predictors of MAL amount of use. 
      The time since stroke less than 36 months (OR = 3.759 (1.149-12.292); p = 0.028), 
      naivety to BoNT-A (OR = 3.322 (1.091-10.118); p = 0.035), and education years (OR 
      = 1.282 (1.050-1.565); p = 0.015) were significant predictors of MAL quality of 
      movement. The findings of our study can help optimize BoNT-A treatment planning.
FAU - Hung, Jen-Wen
AU  - Hung JW
AD  - Department of Rehabilitation, Chang Gung Memorial Hospital-Kaohsiung Medical 
      Center, Kaohsiung 83301, Taiwan.
AD  - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, 
      Taiwan.
FAU - Wu, Wen-Chi
AU  - Wu WC
AD  - Department of Rehabilitation, Chang Gung Memorial Hospital-Kaohsiung Medical 
      Center, Kaohsiung 83301, Taiwan.
FAU - Chen, Yi-Ju
AU  - Chen YJ
AUID- ORCID: 0000-0002-5540-2280
AD  - Department of Rehabilitation, Chang Gung Memorial Hospital-Kaohsiung Medical 
      Center, Kaohsiung 83301, Taiwan.
FAU - Pong, Ya-Ping
AU  - Pong YP
AD  - Department of Rehabilitation, Chang Gung Memorial Hospital-Kaohsiung Medical 
      Center, Kaohsiung 83301, Taiwan.
AD  - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, 
      Taiwan.
FAU - Chang, Ku-Chou
AU  - Chang KC
AD  - School of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, 
      Taiwan.
AD  - Division of Cerebrovascular Diseases, Department of Neurology, Chang Gung 
      Memorial Hospital, Kaohsiung 83301, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211223
PL  - Switzerland
TA  - Toxins (Basel)
JT  - Toxins
JID - 101530765
RN  - EC 3.4.24.69 (Botulinum Toxins, Type A)
SB  - IM
MH  - Adult
MH  - Arm/*physiopathology
MH  - Botulinum Toxins, Type A/*pharmacology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Spasticity/*drug therapy
MH  - *Recovery of Function
MH  - Stroke/*drug therapy
MH  - Stroke Rehabilitation/*standards/statistics & numerical data
PMC - PMC8778339
OTO - NOTNLM
OT  - botulinum toxin
OT  - motor function
OT  - predictors
OT  - stroke
OT  - upper limb spasticity
COIS- The authors declare no conflict of interest.
EDAT- 2022/01/21 06:00
MHDA- 2022/03/03 06:00
PMCR- 2021/12/23
CRDT- 2022/01/20 17:43
PHST- 2021/10/26 00:00 [received]
PHST- 2021/12/16 00:00 [revised]
PHST- 2021/12/20 00:00 [accepted]
PHST- 2022/01/20 17:43 [entrez]
PHST- 2022/01/21 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/12/23 00:00 [pmc-release]
AID - toxins14010013 [pii]
AID - toxins-14-00013 [pii]
AID - 10.3390/toxins14010013 [doi]
PST - epublish
SO  - Toxins (Basel). 2021 Dec 23;14(1):13. doi: 10.3390/toxins14010013.