PMID- 35053749
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220128
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 12
IP  - 1
DP  - 2021 Dec 21
TI  - Clinical Relevance of Cerebrospinal Fluid Antibody Titers in 
      Anti-N-Methyl-d-Aspartate Receptor Encephalitis.
LID - 10.3390/brainsci12010004 [doi]
LID - 4
AB  - Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is the most common 
      autoimmune encephalitis. To date, there has been no study on the relationship 
      between antibody (Ab) titers and clinical phenotype. This study aims to clarify 
      the relationship between cerebrospinal fluid Ab titers and clinical 
      manifestations of anti-NMDAR encephalitis at onset. Seventy-six consecutive 
      patients with a definite diagnosis were enrolled. The relationship between Ab 
      titers and different onset symptoms including psychiatric symptoms, seizures, and 
      memory deficits were analyzed. We further investigated the correlation between Ab 
      titers and clinical severity as assessed by the modified Rankin scale (mRS) and 
      the clinical assessment scale for autoimmune encephalitis (CASE), respectively. 
      The Ab titers had a median value of 1:10 (range 1:1-1:100). There was no 
      significant difference in titers among various clinical factors including gender 
      and combination of tumor and other diseases (each p > 0.05). Patients presenting 
      with psychiatric symptoms at onset had higher titers than those with seizures (p 
      = 0.008) and memory deficits (p = 0.003). The mRS scores revealed a significant 
      but weak correlation with Ab titers (r = 0.243, p = 0.034), while CASE scores did 
      not correlate with the titers (p = 0.125). Our findings indicated that the Ab 
      titers were associated with the type of onset symptoms, with a higher level of 
      patients with psychiatric symptoms. Regarding the clinical severity, the titers 
      showed a weak correlation with the mRS, but no correlation with the CASE.
FAU - Cai, Meng-Ting
AU  - Cai MT
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310009, China.
FAU - Zheng, Yang
AU  - Zheng Y
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310009, China.
FAU - Wang, Sa
AU  - Wang S
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310009, China.
FAU - Lai, Qi-Lun
AU  - Lai QL
AD  - Department of Neurology, Zhejiang Hospital, Hangzhou 310013, China.
FAU - Fang, Gao-Li
AU  - Fang GL
AD  - Department of Neurology, Zhejiang Chinese Medicine and Western Medicine 
      Integrated Hospital, Hangzhou 310003, China.
FAU - Shen, Chun-Hong
AU  - Shen CH
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310009, China.
FAU - Xu, Yong-Feng
AU  - Xu YF
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310009, China.
FAU - Zhang, Yin-Xi
AU  - Zhang YX
AUID- ORCID: 0000-0002-4462-171X
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310009, China.
FAU - Ding, Mei-Ping
AU  - Ding MP
AD  - Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310009, China.
LA  - eng
GR  - 82071443/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20211221
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC8773744
OTO - NOTNLM
OT  - anti-N-methyl-d-aspartate receptor encephalitis
OT  - antibody titer
OT  - cerebrospinal fluid
OT  - modified Rankin scale
OT  - psychiatric symptoms
COIS- The authors declare that there is no conflict of interest.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/22 06:01
PMCR- 2021/12/21
CRDT- 2022/01/21 01:06
PHST- 2021/09/22 00:00 [received]
PHST- 2021/11/24 00:00 [revised]
PHST- 2021/12/09 00:00 [accepted]
PHST- 2022/01/21 01:06 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/22 06:01 [medline]
PHST- 2021/12/21 00:00 [pmc-release]
AID - brainsci12010004 [pii]
AID - brainsci-12-00004 [pii]
AID - 10.3390/brainsci12010004 [doi]
PST - epublish
SO  - Brain Sci. 2021 Dec 21;12(1):4. doi: 10.3390/brainsci12010004.