PMID- 35054095
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220128
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 2
DP  - 2022 Jan 13
TI  - Association between C-Reactive Protein Velocity and Left Ventricular Function in 
      Patients with ST-Elevated Myocardial Infarction.
LID - 10.3390/jcm11020401 [doi]
LID - 401
AB  - C-reactive protein velocity (CRPv), defined as the change in wide-range CRP 
      concentration divided by time, is an inflammatory biomarker associated with 
      increased morbidity and mortality in patients with ST elevation myocardial 
      infarction (STEMI) treated with primary percutaneous intervention (PCI). However, 
      data regarding CRPv association with echocardiographic parameters assessing left 
      ventricular systolic and diastolic function is lacking. Echocardiographic 
      parameters and CRPv values were analyzed using a cohort of 1059 patients admitted 
      with STEMI and treated with primary PCI. Patients were stratified into tertiles 
      according to their CRPv. A receiver operating characteristic (ROC) curve was used 
      to evaluate CRPv optimal cut-off values for the prediction of severe systolic and 
      diastolic dysfunction. Patients with high CRPv tertiles had lower left 
      ventricular ejection fraction (LVEF) (49% vs. 46% vs. 41%, respectively; p < 
      0.001). CRPv was found to independently predict LVEF </= 35% (HR 1.3 CI 95% 
      1.21-1.4; p < 0.001) and grade III diastolic dysfunction (HR 1.16 CI 95% 
      11.02-1.31; p = 0.02). CRPv exhibited a better diagnostic profile for severe 
      systolic dysfunction as compared to CRP (area under the curve 0.734 +/- 0.02 vs. 
      0.608 +/- 0.02). In conclusion, For STEMI patients treated with primary PCI, CRPv 
      is a marker of both systolic and diastolic dysfunction. Further larger studies 
      are needed to support this finding.
FAU - Banai, Ariel
AU  - Banai A
AUID- ORCID: 0000-0002-3464-3341
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel Aviv 64239, Israel.
FAU - Levit, Dana
AU  - Levit D
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel Aviv 64239, Israel.
FAU - Morgan, Samuel
AU  - Morgan S
AUID- ORCID: 0000-0003-4126-0573
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel Aviv 64239, Israel.
FAU - Loewenstein, Itamar
AU  - Loewenstein I
AUID- ORCID: 0000-0002-5550-5490
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel Aviv 64239, Israel.
FAU - Merdler, Ilan
AU  - Merdler I
AUID- ORCID: 0000-0003-3294-5968
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel Aviv 64239, Israel.
FAU - Hochstadt, Aviram
AU  - Hochstadt A
AUID- ORCID: 0000-0002-9404-3145
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel Aviv 64239, Israel.
FAU - Szekely, Yishay
AU  - Szekely Y
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel Aviv 64239, Israel.
FAU - Topilsky, Yan
AU  - Topilsky Y
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel Aviv 64239, Israel.
FAU - Banai, Shmuel
AU  - Banai S
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel Aviv 64239, Israel.
FAU - Shacham, Yacov
AU  - Shacham Y
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel Aviv 64239, Israel.
LA  - eng
PT  - Journal Article
DEP - 20220113
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8781585
OTO - NOTNLM
OT  - CRP velocity
OT  - STEMI
OT  - diastolic dysfunction
OT  - systolic dysfunction
COIS- The authors report no relationships that could be construed as conflicts of 
      interest.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/22 06:01
PMCR- 2022/01/13
CRDT- 2022/01/21 01:07
PHST- 2021/11/28 00:00 [received]
PHST- 2022/01/10 00:00 [revised]
PHST- 2022/01/11 00:00 [accepted]
PHST- 2022/01/21 01:07 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/22 06:01 [medline]
PHST- 2022/01/13 00:00 [pmc-release]
AID - jcm11020401 [pii]
AID - jcm-11-00401 [pii]
AID - 10.3390/jcm11020401 [doi]
PST - epublish
SO  - J Clin Med. 2022 Jan 13;11(2):401. doi: 10.3390/jcm11020401.