PMID- 35055338
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220128
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jan 1
TI  - Intersections between Copper, beta-Arrestin-1, Calcium, FBXW7, CD17, Insulin 
      Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 
      Diabetes Mellitus: A Nomothetic Network Approach.
LID - 10.3390/jpm12010023 [doi]
LID - 23
AB  - Type 2 diabetes mellitus (T2DM) is frequently accompanied by affective disorders 
      with a prevalence of comorbid depression of around 25%. Nevertheless, the 
      biomarkers of affective symptoms including depression and anxiety due to T2DM are 
      not well established. The present study delineated the effects of serum levels of 
      copper, zinc, beta-arrestin-1, FBXW7, lactosylceramide (LacCer), serotonin, calcium, 
      magnesium on severity of depression and anxiety in 58 men with T2DM and 30 
      healthy male controls beyond the effects of insulin resistance (IR) and 
      atherogenicity. Severity of affective symptoms was assessed using the Hamilton 
      Depression and Anxiety rating scales. We found that 61.7% of the variance in 
      affective symptoms was explained by the multivariate regression on copper, 
      beta-arrestin-1, calcium, and IR coupled with atherogenicity. Copper and LacCer 
      (positive) and calcium and BXW7 (inverse) had significant specific indirect 
      effects on affective symptoms, which were mediated by IR and atherogenicity. 
      Copper, beta-arrestin-1, and calcium were associated with affective symptoms above 
      and beyond the effects of IR and atherogenicity. T2DM and affective symptoms 
      share common pathways, namely increased atherogenicity, IR, copper, and 
      beta-arrestin-1, and lowered calcium, whereas copper, beta-arrestin-1, calcium, LacCer, 
      and FBXW7 may modulate depression and anxiety symptoms by affecting T2DM.
FAU - Al-Hakeim, Hussein Kadhem
AU  - Al-Hakeim HK
AUID- ORCID: 0000-0001-6143-5196
AD  - Department of Chemistry, College of Science, University of Kufa, Najaf 54001, 
      Iraq.
FAU - Hadi, Hadi Hasan
AU  - Hadi HH
AD  - Department of Chemistry, College of Science, University of Kufa, Najaf 54001, 
      Iraq.
FAU - Jawad, Ghoufran Akeel
AU  - Jawad GA
AD  - Department of Chemistry, College of Science, University of Kufa, Najaf 54001, 
      Iraq.
FAU - Maes, Michael
AU  - Maes M
AD  - Department of Psychiatry, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
AD  - Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok 
      10330, Thailand.
AD  - IMPACT Strategic Research Centre, School of Medicine, Deakin University, P.O. Box 
      281, Geelong, VIC 3220, Australia.
LA  - eng
PT  - Journal Article
DEP - 20220101
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC8779500
OTO - NOTNLM
OT  - antioxidants
OT  - depression
OT  - inflammation
OT  - mood disorders
OT  - neuro-immune
OT  - nitrosative stress
OT  - oxidative stress
OT  - psychoneuroimmunology
COIS- The authors declare no conflict of interest.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/22 06:01
PMCR- 2022/01/01
CRDT- 2022/01/21 01:11
PHST- 2021/11/24 00:00 [received]
PHST- 2021/12/14 00:00 [revised]
PHST- 2021/12/15 00:00 [accepted]
PHST- 2022/01/21 01:11 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/22 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - jpm12010023 [pii]
AID - jpm-12-00023 [pii]
AID - 10.3390/jpm12010023 [doi]
PST - epublish
SO  - J Pers Med. 2022 Jan 1;12(1):23. doi: 10.3390/jpm12010023.