PMID- 35055342
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220128
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jan 2
TI  - Reduced Incidence of Stroke in Patients with Gout Using Benzbromarone.
LID - 10.3390/jpm12010028 [doi]
LID - 28
AB  - Gout is strongly associated with the incidence of atherosclerotic events, 
      including stroke and myocardial infarction. Considering the increased prevalence 
      of stroke in the population with gout, the aim of this study was to evaluate the 
      effects of benzbromarone, a uricosuric agent, on the incidence of stroke in the 
      population with gout. We used data from the Taiwanese National Health Insurance 
      Registration Database (NHIRD). The benzbromarone user cohort included 15,143 
      patients; each patient was age- and sex-matched with one non-user randomly 
      selected from the population with gout. Cox proportional hazard regression 
      analysis was conducted to estimate the effects of benzbromarone on the incidence 
      of stroke in the population with gout. The incidence of stroke was significantly 
      lower in benzbromarone users than in benzbromarone non-users. The HR for the 
      incidence of stroke was lower in male benzbromarone users than in non-users. An 
      analysis of three age groups (<40, 40-59, and >/=60 years) indicated that the HRs 
      in those aged 40-59 years and >/=60 years were significantly lower among 
      benzbromarone users than non-users. In the population with gout, the incidence of 
      stroke was lower in benzbromarone users than in benzbromarone non-users.
FAU - Niu, Sheng-Wen
AU  - Niu SW
AUID- ORCID: 0000-0002-9355-6686
AD  - Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical 
      University, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan.
AD  - Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 
      807, Taiwan.
AD  - Department of Internal Medicine, Division of Nephrology, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
AD  - Department of Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
FAU - Hung, Chi-Chih
AU  - Hung CC
AD  - Department of Internal Medicine, Division of Nephrology, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
AD  - Department of Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
FAU - Lin, Hugo Y-H
AU  - Lin HY
AUID- ORCID: 0000-0001-6888-4138
AD  - Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 
      807, Taiwan.
AD  - Department of Internal Medicine, Division of Nephrology, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
AD  - Department of Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
FAU - Kuo, I-Ching
AU  - Kuo IC
AD  - Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 
      807, Taiwan.
AD  - Department of Internal Medicine, Division of Nephrology, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
AD  - Department of Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
FAU - Huang, Jiun-Chi
AU  - Huang JC
AUID- ORCID: 0000-0002-5897-2860
AD  - Department of Internal Medicine, Division of Nephrology, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
AD  - Department of Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
FAU - He, Jiun-Shiuan
AU  - He JS
AD  - Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 
      807, Taiwan.
FAU - Wen, Zhi-Hong
AU  - Wen ZH
AUID- ORCID: 0000-0003-4411-044X
AD  - Department of Marine Biotechnology and Resources, National Sun Yat-Sen 
      University, Kaohsiung 807, Taiwan.
FAU - Liang, Peir-In
AU  - Liang PI
AD  - Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical 
      University, Kaohsiung 807, Taiwan.
FAU - Chiu, Yi-Wen
AU  - Chiu YW
AUID- ORCID: 0000-0001-6840-5440
AD  - Department of Internal Medicine, Division of Nephrology, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
AD  - Department of Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
FAU - Chang, Jer-Ming
AU  - Chang JM
AUID- ORCID: 0000-0003-0071-1710
AD  - Department of Internal Medicine, Division of Nephrology, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
AD  - Department of Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
FAU - Hwang, Shang-Jyh
AU  - Hwang SJ
AD  - Department of Internal Medicine, Division of Nephrology, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
AD  - Department of Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung 807, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20220102
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC8779108
OTO - NOTNLM
OT  - benzbromarone
OT  - gout
OT  - stroke
COIS- The authors declare no conflict of interest.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/22 06:01
PMCR- 2022/01/02
CRDT- 2022/01/21 01:11
PHST- 2021/12/04 00:00 [received]
PHST- 2021/12/24 00:00 [revised]
PHST- 2021/12/29 00:00 [accepted]
PHST- 2022/01/21 01:11 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/22 06:01 [medline]
PHST- 2022/01/02 00:00 [pmc-release]
AID - jpm12010028 [pii]
AID - jpm-12-00028 [pii]
AID - 10.3390/jpm12010028 [doi]
PST - epublish
SO  - J Pers Med. 2022 Jan 2;12(1):28. doi: 10.3390/jpm12010028.