PMID- 35055839
OWN - NLM
STAT- MEDLINE
DCOM- 20220225
LR  - 20220225
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 2
DP  - 2022 Jan 17
TI  - Association between Reproductive Factors and Type 2 Diabetes: A Cross-Sectional 
      Study.
LID - 10.3390/ijerph19021019 [doi]
LID - 1019
AB  - (1) Introduction: The available studies on the association between type 2 
      diabetes mellitus (T2DM) and menopause report conflicting results. (2) Objective: 
      This study aimed to investigate the association of menopausal status, age at 
      menopause, and length of the reproductive period with T2DM. (3) Methods: This 
      cross-sectional study is part of the 'China Eastern Cohort Study', which is a 
      community-based cohort study. Multistage, stratified, clustered sampling was used 
      to recruit the study participants in Shanghai, China. Age at menarche and 
      menopause was recorded, and reproductive period was calculated. Weighted logistic 
      regression was used to calculate the prevalence ratios (PRs) with 95% confidence 
      intervals (CIs) of T2DM. Restricted cubic splines were used to assess the 
      relationship between age at menopause, reproductive period, and T2DM. (4) 
      Results: A total of 20,128 women were included. The prevalence of T2DM was 13.7%. 
      Postmenopausal women exhibited a higher prevalence of T2DM than premenopausal 
      women (p < 0.001) and an unfavorable metabolic profile, including higher body 
      mass index, hypertension, and hyperlipidemia. A higher risk of T2DM was observed 
      in postmenopausal women (PR2.12, 95%CI: 1.79-2.51, p < 0.001) compared with 
      premenopausal women, independently of confounding factors. After adjustment for 
      confounding factors, age at menopause and reproductive period were not 
      significantly associated with T2DM. (5) Conclusions: Postmenopausal status is 
      associated with T2DM, while menopausal age and reproductive period are not 
      associated with T2DM. Menopausal status should be considered during T2DM 
      screening.
FAU - Yu, Yuting
AU  - Yu Y
AUID- ORCID: 0000-0001-8113-1851
AD  - Key Laboratory of Public Health Safety of Ministry of Education, School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - Li, Jing
AU  - Li J
AD  - Zhongshan Community Health Center, Shanghai 201613, China.
FAU - Jiang, Yonggen
AU  - Jiang Y
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201600, 
      China.
FAU - Zaid, Maryam
AU  - Zaid M
AD  - Key Laboratory of Public Health Safety of Ministry of Education, School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - Zhao, Qi
AU  - Zhao Q
AUID- ORCID: 0000-0003-0140-3920
AD  - Key Laboratory of Public Health Safety of Ministry of Education, School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - Wang, Na
AU  - Wang N
AUID- ORCID: 0000-0003-0806-4247
AD  - Key Laboratory of Public Health Safety of Ministry of Education, School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - Liu, Xing
AU  - Liu X
AD  - Key Laboratory of Public Health Safety of Ministry of Education, School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - Qiu, Yun
AU  - Qiu Y
AD  - Key Laboratory of Public Health Safety of Ministry of Education, School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - Zhu, Junjie
AU  - Zhu J
AUID- ORCID: 0000-0002-7662-4915
AD  - Key Laboratory of Public Health Safety of Ministry of Education, School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - Tong, Xin
AU  - Tong X
AD  - Key Laboratory of Public Health Safety of Ministry of Education, School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - Cui, Shuheng
AU  - Cui S
AD  - Key Laboratory of Public Health Safety of Ministry of Education, School of Public 
      Health, Fudan University, Shanghai 200032, China.
FAU - Wu, Yiling
AU  - Wu Y
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201600, 
      China.
FAU - Yu, Jianguo
AU  - Yu J
AD  - Zhongshan Community Health Center, Shanghai 201613, China.
FAU - Zhao, Genming
AU  - Zhao G
AD  - Key Laboratory of Public Health Safety of Ministry of Education, School of Public 
      Health, Fudan University, Shanghai 200032, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220117
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Age Factors
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Female
MH  - Humans
MH  - Menopause
MH  - Risk Factors
PMC - PMC8775663
OTO - NOTNLM
OT  - cross-sectional study
OT  - menopause
OT  - reproductive period
OT  - type 2 diabetes
OT  - woman health
COIS- All authors certify that they have no affiliations with or involvement in any 
      organization or entity with any financial or non-financial interest in the 
      subject matter or materials discussed in this manuscript.
EDAT- 2022/01/22 06:00
MHDA- 2022/02/26 06:00
PMCR- 2022/01/17
CRDT- 2022/01/21 01:12
PHST- 2021/12/13 00:00 [received]
PHST- 2022/01/14 00:00 [revised]
PHST- 2022/01/15 00:00 [accepted]
PHST- 2022/01/21 01:12 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/02/26 06:00 [medline]
PHST- 2022/01/17 00:00 [pmc-release]
AID - ijerph19021019 [pii]
AID - ijerph-19-01019 [pii]
AID - 10.3390/ijerph19021019 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Jan 17;19(2):1019. doi: 
      10.3390/ijerph19021019.