PMID- 35055967
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220128
IS  - 2076-0817 (Print)
IS  - 2076-0817 (Electronic)
IS  - 2076-0817 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Dec 24
TI  - Distinct Schistosoma mansoni-Specific Immunoglobulin Subclasses Are Induced by 
      Different Schistosoma mansoni Stages-A Tool to Decipher Schistosoma mansoni 
      Infection Stages.
LID - 10.3390/pathogens11010019 [doi]
LID - 19
AB  - Despite the existence of an effective medication against schistosomiasis, the 
      disease remains a major health problem in affected areas, especially for those 
      lacking appropriate sanitary facilities. Moreover, treatment cannot prevent 
      re-infection since it is only effective on adult schistosome worms. Previous 
      retrospective studies in the Sudan have discovered unique immuno-epidemiological 
      profiles in uninfected individuals and those positive for Schistosoma mansoni via 
      polymerase chain reaction (PCR) but egg-negative and those with eggs in their 
      stool. Expanding on these data, serum samples from these individuals were further 
      investigated for the presence of cercarial (SmCTF)-specific antibodies, which 
      would indicate immune responses at the early stages of infection. Indeed, SmCTF 
      IgG1, 2, 3 and 4 levels were significantly elevated in SmPCR(+) individuals when 
      compared to egg(+) patients. Following multivariable regression analysis, 
      including SmCTF-specific Igs, Schistosoma egg antigen (SEA)-specific and 
      Schistosoma worm antigen (SWA)-specific immunoglobulins revealed a specific 
      immunoglobulin (Ig) profile of individuals presenting different states of 
      infection, which may be a useful future tool in order to identify egg(-) 
      individuals and thereby prevent unnecessary treatments.
FAU - Arndts, Kathrin
AU  - Arndts K
AUID- ORCID: 0000-0003-1091-4861
AD  - Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), 
      University Hospital Bonn (UKB), 53127 Bonn, Germany.
FAU - Elfaki, Tayseer E M
AU  - Elfaki TEM
AD  - Department of Parasitology and Medical Entomology, College of Medical Laboratory 
      Science, Sudan University of Science and Technology, Khartoum 13311, Sudan.
FAU - Doenhoff, Michael J
AU  - Doenhoff MJ
AD  - School of Life Sciences, University of Nottingham, University Park, Nottingham 
      NG7 2RD, UK.
FAU - Katawa, Gnatoulma
AU  - Katawa G
AUID- ORCID: 0000-0002-4591-5672
AD  - Unite de Recherche en Immunologie et Immunomodulation (UR2IM), Ecole Superieure 
      des Techniques Biologiques et Alimentaires (ESTBA), University of Lome, Lome BP 
      1515, Togo.
FAU - Goreish, Ibtisam A
AU  - Goreish IA
AD  - Animal Resources Research Corporation, Ministry of Livestock, Fisheries and 
      Rangelands, Khartoum 13311, Sudan.
FAU - Atti El Mekki, Misk El Yemen A
AU  - Atti El Mekki MEYA
AD  - Department of Parasitology and Medical Entomology, College of Medical Laboratory 
      Science, Sudan University of Science and Technology, Khartoum 13311, Sudan.
FAU - Hoerauf, Achim
AU  - Hoerauf A
AD  - Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), 
      University Hospital Bonn (UKB), 53127 Bonn, Germany.
AD  - German Centre for Infection Research (DZIF), Neglected Tropical Disease, Partner 
      Site, Bonn-Cologne, 53127 Bonn, Germany.
AD  - German-West African Centre for Global Health and Pandemic Prevention (G-WAC), 
      Partner Site Bonn, 53127 Bonn, Germany.
FAU - Ritter, Manuel
AU  - Ritter M
AUID- ORCID: 0000-0001-8667-2067
AD  - Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), 
      University Hospital Bonn (UKB), 53127 Bonn, Germany.
FAU - Layland, Laura E
AU  - Layland LE
AD  - Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), 
      University Hospital Bonn (UKB), 53127 Bonn, Germany.
AD  - German Centre for Infection Research (DZIF), Neglected Tropical Disease, Partner 
      Site, Bonn-Cologne, 53127 Bonn, Germany.
LA  - eng
GR  - LA 2746/2-1/Deutsche Forschungsgemeinschaft/
PT  - Journal Article
DEP - 20211224
PL  - Switzerland
TA  - Pathogens
JT  - Pathogens (Basel, Switzerland)
JID - 101596317
PMC - PMC8778779
OTO - NOTNLM
OT  - Schistosoma mansoni
OT  - Sudan
OT  - cercarial transformation fluid (SmCTF)
OT  - immunoglobulins
OT  - multivariable regression analysis
COIS- The authors of this work have no financial, personal or professional interests 
      that could have been construed to influence this manuscript.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/22 06:01
PMCR- 2021/12/24
CRDT- 2022/01/21 01:12
PHST- 2021/10/11 00:00 [received]
PHST- 2021/12/10 00:00 [revised]
PHST- 2021/12/16 00:00 [accepted]
PHST- 2022/01/21 01:12 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/22 06:01 [medline]
PHST- 2021/12/24 00:00 [pmc-release]
AID - pathogens11010019 [pii]
AID - pathogens-11-00019 [pii]
AID - 10.3390/pathogens11010019 [doi]
PST - epublish
SO  - Pathogens. 2021 Dec 24;11(1):19. doi: 10.3390/pathogens11010019.