PMID- 35055987
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231105
IS  - 2076-0817 (Print)
IS  - 2076-0817 (Electronic)
IS  - 2076-0817 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Dec 31
TI  - HIV-1 trans-Infection Mediated by DCs: The Tip of the Iceberg of Cell-to-Cell 
      Viral Transmission.
LID - 10.3390/pathogens11010039 [doi]
LID - 39
AB  - HIV-1 cell-to-cell transmission is key for an effective viral replication that 
      evades immunity. This highly infectious mechanism is orchestrated by different 
      cellular targets that utilize a wide variety of processes to efficiently transfer 
      HIV-1 particles. Dendritic cells (DCs) are the most potent antigen presenting 
      cells that initiate antiviral immune responses, but are also the cells with 
      highest capacity to transfer HIV-1. This mechanism, known as trans-infection, 
      relies on the capacity of DCs to capture HIV-1 particles via lectin receptors 
      such as the sialic acid-binding I-type lectin Siglec-1/CD169. The discovery of 
      the molecular interaction of Siglec-1 with sialylated lipids exposed on HIV-1 
      membranes has enlightened how this receptor can bind to several enveloped 
      viruses. The outcome of these interactions can either mount effective immune 
      responses, boost the productive infection of DCs and favour innate sensing, or 
      fuel viral transmission via trans-infection. Here we review these scenarios 
      focusing on HIV-1 and other enveloped viruses such as Ebola virus or SARS-CoV-2.
FAU - Perez-Zsolt, Daniel
AU  - Perez-Zsolt D
AD  - IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916 Badalona, Spain.
FAU - Raich-Regue, Dalia
AU  - Raich-Regue D
AUID- ORCID: 0000-0001-7656-5700
AD  - IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916 Badalona, Spain.
FAU - Munoz-Basagoiti, Jordana
AU  - Munoz-Basagoiti J
AD  - IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916 Badalona, Spain.
FAU - Aguilar-Gurrieri, Carmen
AU  - Aguilar-Gurrieri C
AD  - IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916 Badalona, Spain.
FAU - Clotet, Bonaventura
AU  - Clotet B
AD  - IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916 Badalona, Spain.
AD  - Infectious Diseases and Immunity Department, Faculty of Medicine, University of 
      Vic-Central University of Catalonia (UVic-UCC), 08500 Vic, Spain.
FAU - Blanco, Julia
AU  - Blanco J
AUID- ORCID: 0000-0002-2225-0217
AD  - IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916 Badalona, Spain.
AD  - Infectious Diseases and Immunity Department, Faculty of Medicine, University of 
      Vic-Central University of Catalonia (UVic-UCC), 08500 Vic, Spain.
AD  - Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, 
      Spain.
FAU - Izquierdo-Useros, Nuria
AU  - Izquierdo-Useros N
AUID- ORCID: 0000-0002-1039-1821
AD  - IrsiCaixa AIDS Research Institute, Can Ruti Campus, 08916 Badalona, Spain.
AD  - Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, 08916 Badalona, 
      Spain.
LA  - eng
GR  - PID2020-117145RB-I00/Spanish Ministry of Science and Innovation/
PT  - Journal Article
PT  - Review
DEP - 20211231
PL  - Switzerland
TA  - Pathogens
JT  - Pathogens (Basel, Switzerland)
JID - 101596317
PMC - PMC8778849
OTO - NOTNLM
OT  - DC
OT  - Ebola virus
OT  - HIV-1
OT  - SARS-CoV-2
OT  - trans-infection
COIS- N.I.-U. reports patent applications related to Siglec-1 viral interactions, and 
      institutional grants from Grifols, Pharma Mar, Hipra, Dentaid & Palobiofarma. 
      Unrelated to the submitted work, J.B. and B.C. are founders and shareholders of 
      AlbaJuna Therapeutics, S.L.; B.C. is founder and shareholder of AELIX 
      Therapeutics, S.L. The authors declare that no other competing financial 
      interests exist.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/22 06:01
PMCR- 2021/12/31
CRDT- 2022/01/21 01:13
PHST- 2021/11/12 00:00 [received]
PHST- 2021/12/20 00:00 [revised]
PHST- 2021/12/22 00:00 [accepted]
PHST- 2022/01/21 01:13 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/22 06:01 [medline]
PHST- 2021/12/31 00:00 [pmc-release]
AID - pathogens11010039 [pii]
AID - pathogens-11-00039 [pii]
AID - 10.3390/pathogens11010039 [doi]
PST - epublish
SO  - Pathogens. 2021 Dec 31;11(1):39. doi: 10.3390/pathogens11010039.