PMID- 35056113
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240405
IS  - 1424-8247 (Print)
IS  - 1424-8247 (Electronic)
IS  - 1424-8247 (Linking)
VI  - 15
IP  - 1
DP  - 2022 Jan 1
TI  - Adsorption and Sustained Delivery of Small Molecules from Nanosilicate Hydrogel 
      Composites.
LID - 10.3390/ph15010056 [doi]
LID - 56
AB  - Two-dimensional nanosilicate particles (NS) have shown promise for the prolonged 
      release of small-molecule therapeutics while minimizing burst release. When 
      incorporated in a hydrogel, the high surface area and charge of NS enable 
      electrostatic adsorption and/or intercalation of therapeutics, providing a lever 
      to localize and control release. However, little is known about the 
      physio-chemical interplay between the hydrogel, NS, and encapsulated small 
      molecules. Here, we fabricated polyethylene glycol (PEG)-NS hydrogels for the 
      release of model small molecules such as acridine orange (AO). We then elucidated 
      the effect of NS concentration, NS/AO incubation time, and the ability of NS to 
      freely associate with AO on hydrogel properties and AO release profiles. Overall, 
      NS incorporation increased the hydrogel stiffness and decreased swelling and mesh 
      size. When individual NS particles were embedded within the hydrogel, a 70-fold 
      decrease in AO release was observed compared to PEG-only hydrogels, due to 
      adsorption of AO onto NS surfaces. When NS was pre-incubated and complexed with 
      AO prior to hydrogel encapsulation, a >9000-fold decrease in AO release was 
      observed due to intercalation of AO between NS layers. Similar results were 
      observed for other small molecules. Our results show the potential for use of 
      these nanocomposite hydrogels for the tunable, long-term release of small 
      molecules.
FAU - Stealey, Samuel
AU  - Stealey S
AD  - Biomedical Engineering Program, Parks College of Engineering, Saint Louis 
      University, Saint Louis, MO 63103, USA.
FAU - Khachani, Mariam
AU  - Khachani M
AD  - Biomedical Engineering Program, Parks College of Engineering, Saint Louis 
      University, Saint Louis, MO 63103, USA.
FAU - Zustiak, Silviya Petrova
AU  - Zustiak SP
AUID- ORCID: 0000-0002-7648-8351
AD  - Biomedical Engineering Program, Parks College of Engineering, Saint Louis 
      University, Saint Louis, MO 63103, USA.
LA  - eng
GR  - 01285/Institute for Drug and Biotherapeutic Innovation-Saint Louis University 
      Seed Grant/
PT  - Journal Article
DEP - 20220101
PL  - Switzerland
TA  - Pharmaceuticals (Basel)
JT  - Pharmaceuticals (Basel, Switzerland)
JID - 101238453
PMC - PMC8780425
OTO - NOTNLM
OT  - acridine orange
OT  - intercalation
OT  - laponite
OT  - nanocomposite
OT  - polyethylene glycol hydrogel
OT  - therapeutic delivery
COIS- The authors declare no conflict of interest.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/22 06:01
PMCR- 2022/01/01
CRDT- 2022/01/21 01:13
PHST- 2021/12/07 00:00 [received]
PHST- 2021/12/20 00:00 [revised]
PHST- 2021/12/29 00:00 [accepted]
PHST- 2022/01/21 01:13 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/22 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - ph15010056 [pii]
AID - pharmaceuticals-15-00056 [pii]
AID - 10.3390/ph15010056 [doi]
PST - epublish
SO  - Pharmaceuticals (Basel). 2022 Jan 1;15(1):56. doi: 10.3390/ph15010056.