PMID- 35056346
OWN - NLM
STAT- MEDLINE
DCOM- 20220124
LR  - 20220128
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 58
IP  - 1
DP  - 2021 Dec 27
TI  - Colonic Diverticulosis and Non-Alcoholic Fatty Liver Disease: Is There a 
      Connection?
LID - 10.3390/medicina58010038 [doi]
LID - 38
AB  - Background and Objectives: The development and severity of colonic diverticulosis 
      and non-alcoholic fatty liver disease (NAFLD) has been associated with several 
      components of metabolic syndrome (MetS). Therefore, this study aimed to evaluate 
      a possible connection between NAFLD, colonic diverticulosis, and MetS. Materials 
      and Methods: This retrospective study included patients diagnosed with 
      diverticulosis between January 2017 and December 2019. Data regarding the patient 
      demographics, Diverticular Inflammation and Complication Assessment (DICA) score 
      and category, disease localization, hepatic steatosis, blood pressure, 
      comprehensive metabolic panel, need for colonic surgery, and co-morbidities were 
      collected from medical records. Results: A total of 407 patients with a median 
      age of 68 years (range, 34-89 years) were included (male: 53.81%). The majority 
      was diagnosed with left-sided diverticulosis (n = 367, 90.17%) and an 
      uncomplicated disease course (DICA category 1, n = 347, 85.3%). Concomitant 
      hepatic steatosis was detected in 47.42% (n = 193) of patients. The systolic 
      blood pressure, triglycerides, total cholesterol, C-reactive protein (CRP), and 
      fasting glucose were higher in the NAFLD group (p < 0.001, p < 0.001, p < 0.001, 
      p < 0.001, and p < 0.001, respectively). A higher prevalence of hypertension 
      (HTA), type 2 diabetes mellitus (T2DM), and hypothyroidism was noted in the same 
      group of patients (p < 0.001, p < 0.001, and p = 0.008, respectively). 
      High-density lipoprotein cholesterol was lower in patients with more severe forms 
      of diverticulosis (DICA category 2 and 3), while CRP levels were significantly 
      higher (p = 0.006 and p = 0.015, respectively). HTA and NAFLD were more common in 
      patients with more severe forms of colonic diverticulosis (p = 0.016 and p = 
      0.025, respectively). Using a multivariate logistic regression, the DICA score, 
      CRP, total cholesterol, HTA, and hypothyroidism were identified as discriminating 
      factors for the presence of hepatic steatosis. Conclusion: Components of 
      metabolic dysregulation were prominent in patients diagnosed with colonic 
      diverticulosis and concomitant hepatic steatosis. HTA, T2DM, and hypothyroidism 
      were more frequently observed in this group. Hepatic steatosis was more commonly 
      detected in more severe forms of colonic diverticulosis.
FAU - Pantic, Ivana
AU  - Pantic I
AUID- ORCID: 0000-0003-1137-1141
AD  - Clinic of Gastroenterology and Hepatology, University Clinical Center of Serbia, 
      11000 Belgrade, Serbia.
FAU - Lugonja, Sofija
AU  - Lugonja S
AD  - Department of Internal Medicine, Division of Gastroenterology, General Hospital 
      "Djordje Joanovic", 23000 Zrenjanin, Serbia.
FAU - Rajovic, Nina
AU  - Rajovic N
AD  - Faculty of Medicine, Institute for Medical Statistics and Informatics, University 
      of Belgrade, 11000 Belgrade, Serbia.
FAU - Dumic, Igor
AU  - Dumic I
AUID- ORCID: 0000-0002-5312-8812
AD  - Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
AD  - Division of Hospital Internal Medicine, Mayo Clinic Health System, Eau Claire, WI 
      54702, USA.
FAU - Milovanovic, Tamara
AU  - Milovanovic T
AD  - Clinic of Gastroenterology and Hepatology, University Clinical Center of Serbia, 
      11000 Belgrade, Serbia.
AD  - Department of Internal Medicine, Faculty of Medicine, University of Belgrade, 
      11000 Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20211227
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Diabetes Mellitus, Type 2
MH  - *Diverticulosis, Colonic/complications/epidemiology
MH  - Humans
MH  - Male
MH  - *Metabolic Syndrome/complications/epidemiology
MH  - Middle Aged
MH  - *Non-alcoholic Fatty Liver Disease/complications/epidemiology
MH  - Retrospective Studies
PMC - PMC8778461
OTO - NOTNLM
OT  - colonic diverticulosis
OT  - metabolic syndrome
OT  - non-alcoholic fatty liver disease
COIS- The authors declare no conflict of interest.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/27 06:00
PMCR- 2021/12/27
CRDT- 2022/01/21 01:14
PHST- 2021/12/05 00:00 [received]
PHST- 2021/12/18 00:00 [revised]
PHST- 2021/12/24 00:00 [accepted]
PHST- 2022/01/21 01:14 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/12/27 00:00 [pmc-release]
AID - medicina58010038 [pii]
AID - medicina-58-00038 [pii]
AID - 10.3390/medicina58010038 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2021 Dec 27;58(1):38. doi: 10.3390/medicina58010038.