PMID- 35057533
OWN - NLM
STAT- MEDLINE
DCOM- 20220126
LR  - 20220128
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 2
DP  - 2022 Jan 14
TI  - Dietary Exposure to Polychlorinated Biphenyls and Dioxins and Its Relationship to 
      Telomere Length in Subjects Older Than 55 Years from the SUN Project.
LID - 10.3390/nu14020353 [doi]
LID - 353
AB  - Exposure to persistent organic pollutants (POPs) may influence telomere length 
      (TL), which is considered as a marker of biological age associated with the risk 
      of chronic disease. We hypothesized that dietary exposure to polychlorinated 
      biphenyls (PCBs) and dioxins could affect TL. Our aim was to evaluate the 
      association of dietary exposure to PCBs and dioxins with TL. In this 
      cross-sectional study of 886 subjects older than 55 y (mean age: 67.7; standard 
      deviation (SD): 6.1; 27% women) from the "Seguimiento Universidad de Navarra" 
      (SUN) project. TL was determined by real-time quantitative polymerase chain 
      reaction and dietary PCBs and dioxins exposure was collected using a validated 
      136-item Food Frequency Questionnaire. Multivariable linear regression models 
      were used to control for potential confounding factors. Shorter TL was associated 
      with dietary total PCBs (SD of T/S ratio/(ng/day) = -0.30 x 10(-7); 95% CI, -0.55 
      x 10(-7) to -0.06 x 10(-7)), dioxin-like PCBs (DL-PCBs) (SD of T/S ratio/(pg WHO 
      TEQ (Toxic Equivalents)/day) = -6.17 x 10(-7); 95% CI, -11.30 x 10(-7) to -1.03 x 
      10(-7)), and total TEQ exposure (SD of T/S ratio/(pg WHO TEQ/day) = -5.02 x 
      10(-7); 95% CI, -9.44 x 10(-7) to -0.61 x 10(-7)), but not with dioxins (SD of 
      T/S ratio/(pg WHO TEQ/day) = -13.90 x 10(-7); 95% CI, -37.70 x 10(-7) to 9.79 x 
      10(-7)). In this sample of middle-aged and older Spanish adults, dietary exposure 
      to total PCBs and DL-PCBs alone and together with dioxins was associated with 
      shorter TL. Further longitudinal studies, preferably with POPs measured in 
      biological samples, are needed to confirm this finding.
FAU - Alonso-Pedrero, Lucia
AU  - Alonso-Pedrero L
AD  - Department of Nutrition, Food Science and Physiology, University of Navarra, 
      31008 Pamplona, Spain.
AD  - Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
FAU - Donat-Vargas, Carolina
AU  - Donat-Vargas C
AUID- ORCID: 0000-0002-4523-4148
AD  - Departament of Preventive Medicine and Public Health, School of Medicine, 
      Universidad Autonoma de Madrid, CEI UAM+ CSIC, 28049 Madrid, Spain.
AD  - Unit of Nutritional and Cardiovascular Epidemiology, Environmental Medicine 
      Institute (IMM), Karolinska Institutet, 17177 Stockholm, Sweden.
AD  - Physiopathology of Obesity and Nutrition Networking Biomedical Research Centre 
      (CIBERobn), Spanish National Institute of Health Carlos III, 28029 Madrid, Spain.
FAU - Bes-Rastrollo, Maira
AU  - Bes-Rastrollo M
AUID- ORCID: 0000-0002-9139-4206
AD  - Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
AD  - Physiopathology of Obesity and Nutrition Networking Biomedical Research Centre 
      (CIBERobn), Spanish National Institute of Health Carlos III, 28029 Madrid, Spain.
AD  - Department of Preventive Medicine and Public Health, University of Navarra, 31008 
      Pamplona, Spain.
FAU - Ojeda-Rodriguez, Ana
AU  - Ojeda-Rodriguez A
AD  - Department of Nutrition, Food Science and Physiology, University of Navarra, 
      31008 Pamplona, Spain.
AD  - Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
FAU - Zalba, Guillermo
AU  - Zalba G
AUID- ORCID: 0000-0003-4616-1523
AD  - Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
AD  - Department of Biochemistry and Genetics, University of Navarra, 31008 Pamplona, 
      Spain.
FAU - Razquin, Cristina
AU  - Razquin C
AUID- ORCID: 0000-0003-3480-2645
AD  - Physiopathology of Obesity and Nutrition Networking Biomedical Research Centre 
      (CIBERobn), Spanish National Institute of Health Carlos III, 28029 Madrid, Spain.
AD  - Department of Preventive Medicine and Public Health, University of Navarra, 31008 
      Pamplona, Spain.
FAU - Martinez-Gonzalez, Miguel A
AU  - Martinez-Gonzalez MA
AUID- ORCID: 0000-0002-3917-9808
AD  - Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
AD  - Physiopathology of Obesity and Nutrition Networking Biomedical Research Centre 
      (CIBERobn), Spanish National Institute of Health Carlos III, 28029 Madrid, Spain.
AD  - Department of Preventive Medicine and Public Health, University of Navarra, 31008 
      Pamplona, Spain.
AD  - Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 
      02115, USA.
FAU - Marti, Amelia
AU  - Marti A
AUID- ORCID: 0000-0001-9832-7981
AD  - Department of Nutrition, Food Science and Physiology, University of Navarra, 
      31008 Pamplona, Spain.
AD  - Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
AD  - Physiopathology of Obesity and Nutrition Networking Biomedical Research Centre 
      (CIBERobn), Spanish National Institute of Health Carlos III, 28029 Madrid, Spain.
LA  - eng
GR  - (27/2011, 45/2011, 122/2014)/University of Navarra and Navarra Regional 
      Government/
GR  - (RD 06/0045, CIBER-OBN, and Fondo de Investigaciones sanitarias, Grants 
      PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, 
      PI17/01795, PI20/00564 and G03/140)/Spanish Government-Instituto de Salud Carlos 
      III and the European Regional Development Fund (FEDER)/
GR  - (2020/021)/PNDS (Plan Nacional sobre Drogas)/
PT  - Journal Article
DEP - 20220114
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Dioxins)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Cross-Sectional Studies
MH  - Diet/*adverse effects/statistics & numerical data
MH  - Diet Surveys
MH  - Dietary Exposure/*adverse effects
MH  - Dioxins/*toxicity
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Spain
MH  - Telomere Homeostasis/drug effects
MH  - Telomere Shortening/*drug effects
PMC - PMC8779661
OTO - NOTNLM
OT  - Seguimiento Universidad de Navarra (SUN) study
OT  - cross-sectional study
OT  - dioxins
OT  - nutritional epidemiology
OT  - polychlorinated biphenyls (PCBs)
OT  - telomere length (TL)
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/27 06:00
PMCR- 2022/01/14
CRDT- 2022/01/21 01:17
PHST- 2021/11/23 00:00 [received]
PHST- 2022/01/10 00:00 [revised]
PHST- 2022/01/11 00:00 [accepted]
PHST- 2022/01/21 01:17 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2022/01/14 00:00 [pmc-release]
AID - nu14020353 [pii]
AID - nutrients-14-00353 [pii]
AID - 10.3390/nu14020353 [doi]
PST - epublish
SO  - Nutrients. 2022 Jan 14;14(2):353. doi: 10.3390/nu14020353.