PMID- 35057819
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231102
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 19
IP  - 1
DP  - 2022 Jan 20
TI  - A comprehensive insight into the molecular and cellular mechanisms of the effects 
      of Propolis on preserving renal function: a systematic review.
PG  - 6
LID - 10.1186/s12986-021-00639-z [doi]
LID - 6
AB  - BACKGROUND: The present systematic review is conducted, focusing on the existing 
      evidence of Propolis's effects due to its various health benefits, mainly 
      antioxidant and anti-inflammatory properties on preserving renal function. 
      METHODS: A systematic search of PubMed, Scopus, Embase, ProQuest, and Google 
      Scholar was undertaken for relevant papers published from the start until January 
      2021. RESULTS: This review revealed that Propolis affects fasting blood sugar 
      (FBS), postprandial blood glucose, advanced glycation end products (AGEs) 
      concentrations, malondialdehyde (MDA) levels, urinary concentrations of reactive 
      oxygen metabolites (Tbars), total oxidant status (TOS), oxidative stress index 
      (OSI), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation favorably. The findings 
      on hemoglobin A1C (HbA1C), insulin, homeostasis model assessment of insulin 
      resistance (HOMA-IR), beta-cell function (HOMA-beta), quantitative insulin sensitivity 
      check index (QUICKI), and lipid profile were controversial. Moreover, a 
      significant reduction in renal nuclear factor kappa B (NF-kappaB), serum 
      immunoglobulins, renal ED-1(+) cells, and urinary monocyte chemoattractant 
      protein-1 (MCP-1) following Propolis supplementation has been reported, while the 
      results on interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), nitric oxide 
      (NO), nitric oxide synthetase (NOS), and high sensitivity C-reactive protein 
      (hs-CRP) were controversial. Furthermore, included studies showed its anti- 
      proteinuria and kidney restoring effects. CONCLUSION: In this review, both human 
      and animal studies provide us evidences that Propolis could potentially improve 
      the glycemic status, oxidative stress, renal tissue damage, and renal function. 
      Further studies are needed to determine the underlying mechanisms.
CI  - (c) 2022. The Author(s).
FAU - Anvarifard, Paniz
AU  - Anvarifard P
AD  - Student Research Committee, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Anbari, Maryam
AU  - Anbari M
AD  - Student Research Committee, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Ostadrahimi, Alireza
AU  - Ostadrahimi A
AD  - Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
AD  - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Attar-Neishaburi St., Golgasht Alley, Azadi 
      Blvd., Tabriz, Iran.
FAU - Ardalan, Mohammadreza
AU  - Ardalan M
AD  - Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Ghoreishi, Zohreh
AU  - Ghoreishi Z
AUID- ORCID: 0000-0001-7522-5755
AD  - Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 
      ghoreyshiz@tbzmed.ac.ir.
AD  - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Attar-Neishaburi St., Golgasht Alley, Azadi 
      Blvd., Tabriz, Iran. ghoreyshiz@tbzmed.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220120
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC8772196
OTO - NOTNLM
OT  - AKI
OT  - Acute kidney injury
OT  - CKD
OT  - Chronic kidney disease
OT  - Kidney disease
OT  - Propolis
OT  - Renal function
OT  - Systematic review
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/01/22 06:00
MHDA- 2022/01/22 06:01
PMCR- 2022/01/20
CRDT- 2022/01/21 05:44
PHST- 2021/05/19 00:00 [received]
PHST- 2021/12/21 00:00 [accepted]
PHST- 2022/01/21 05:44 [entrez]
PHST- 2022/01/22 06:00 [pubmed]
PHST- 2022/01/22 06:01 [medline]
PHST- 2022/01/20 00:00 [pmc-release]
AID - 10.1186/s12986-021-00639-z [pii]
AID - 639 [pii]
AID - 10.1186/s12986-021-00639-z [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2022 Jan 20;19(1):6. doi: 10.1186/s12986-021-00639-z.