PMID- 35058581 OWN - NLM STAT- MEDLINE DCOM- 20220421 LR - 20221024 IS - 1476-5365 (Electronic) IS - 0268-3369 (Linking) VI - 57 IP - 3 DP - 2022 Mar TI - Human leukocyte antigen (HLA) haplotype matching in unrelated single HLA allele mismatch bone marrow transplantation. PG - 407-415 LID - 10.1038/s41409-021-01552-y [doi] AB - The role of matching human leukocyte antigen (HLA) haplotypes in unrelated allogeneic bone marrow transplantation (allo-BMT) remains unclear. Here, we imputed the HLA haplotypes of 3657 patients who received unrelated single HLA allele-mismatched allo-BMT, included from the Transplant Registry Unified Management Program (TRUMP) database, the Japanese registry program for hematopoietic transplantation, using mathematical methods. We successfully imputed the HLA haplotypes of both patients and donors in 1365 cases (37.3%) with >/=90% probability. Of the patients, 1326 (97.1%) and 39 (2.9%) were categorized into one-haplotype-matched and no-haplotype-matched groups, respectively. Disease-free survival was significantly worse in the no-haplotype-matched group. Multivariate analyses revealed that no-haplotype-match was an independent risk factor for reducing disease-free survival (hazard ratio, 1.54 [95% confidence interval: 1.01-2.36]; p = 0.047). However, the overall survival did not significantly differ between the groups. The incidence of grade III-IV acute and chronic graft-versus-host disease did not significantly differ between the groups. Furthermore, there were no significant differences in the cumulative incidences of relapse and non-relapse mortality between the groups. Our findings suggest that imputing haplotypes using a mathematical approach can help to avoid transplanting patients with donors who do not share matching haplotypes, thereby improving the outcome of allo-BMT. CI - (c) 2021. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Kawajiri, Akihisa AU - Kawajiri A AUID- ORCID: 0000-0002-5989-7786 AD - Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan. akawajiri@med.tohoku.ac.jp. FAU - Kawase, Takakazu AU - Kawase T AD - Department of Immune Regenerative Medicine, International Center for Cell and Gene Therapy, Research Promotion And Support Headquarters, Fujita Health University, Toyoake, Japan. FAU - Tanaka, Hidenori AU - Tanaka H AUID- ORCID: 0000-0001-6169-290X AD - HLA Foundation Laboratory, Kyoto, Japan. FAU - Fukuda, Takahiro AU - Fukuda T AD - Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan. FAU - Mukae, Junichi AU - Mukae J AD - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan. FAU - Ozawa, Yukiyasu AU - Ozawa Y AD - Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan. FAU - Eto, Tetsuya AU - Eto T AD - Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan. FAU - Uchida, Naoyuki AU - Uchida N AUID- ORCID: 0000-0001-5952-5926 AD - Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan. FAU - Mori, Takehiko AU - Mori T AUID- ORCID: 0000-0002-8176-4760 AD - Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. AD - Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan. FAU - Ashida, Takashi AU - Ashida T AUID- ORCID: 0000-0001-8238-8501 AD - Division of Hematology and Rheumatology, Department of Internal Medicine, Kindai University Hospital, Osakasayama, Japan. FAU - Kondo, Tadakazu AU - Kondo T AUID- ORCID: 0000-0002-8959-6271 AD - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. FAU - Onizuka, Makoto AU - Onizuka M AUID- ORCID: 0000-0003-3864-0823 AD - Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan. FAU - Ichinohe, Tatsuo AU - Ichinohe T AUID- ORCID: 0000-0002-0393-4066 AD - Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan. FAU - Atsuta, Yoshiko AU - Atsuta Y AUID- ORCID: 0000-0003-4404-2870 AD - Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan. AD - Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Morishima, Satoko AU - Morishima S AUID- ORCID: 0000-0002-7391-4271 AD - Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan. FAU - Kanda, Junya AU - Kanda J AUID- ORCID: 0000-0002-6704-3633 AD - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. CN - HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation LA - eng PT - Journal Article DEP - 20220121 PL - England TA - Bone Marrow Transplant JT - Bone marrow transplantation JID - 8702459 RN - 0 (HLA Antigens) RN - 0 (Histocompatibility Antigens Class I) SB - IM MH - Alleles MH - Bone Marrow Transplantation/adverse effects MH - *Graft vs Host Disease/etiology MH - HLA Antigens/genetics MH - Haplotypes MH - *Hematopoietic Stem Cell Transplantation/methods MH - Histocompatibility Antigens Class I MH - Humans MH - Neoplasm Recurrence, Local MH - Treatment Outcome MH - Unrelated Donors EDAT- 2022/01/22 06:00 MHDA- 2022/04/22 06:00 CRDT- 2022/01/21 06:13 PHST- 2021/02/28 00:00 [received] PHST- 2021/12/08 00:00 [accepted] PHST- 2021/11/03 00:00 [revised] PHST- 2022/01/22 06:00 [pubmed] PHST- 2022/04/22 06:00 [medline] PHST- 2022/01/21 06:13 [entrez] AID - 10.1038/s41409-021-01552-y [pii] AID - 10.1038/s41409-021-01552-y [doi] PST - ppublish SO - Bone Marrow Transplant. 2022 Mar;57(3):407-415. doi: 10.1038/s41409-021-01552-y. Epub 2022 Jan 21.